Clinical trials: Pyrexia
Febrile Neutropenia, Neutropenia
Prevention of Febrile Neutropenia by Synbiotics in Pediatric Cancer Patients
Febrile neutropenia (FN) is a major life-threatening treatment complication in cancer patients undergoing intensive chemotherapy. Endogenous flora is considered to be one of the main sources of infections during neutropenia.
- Conditions
- Febrile Neutropenia, Neutropenia, Infection in an Immunocompromised Host, Cancer
- Trial name
- FENSY (NCT02544685)
- Testing
- Probio-Fix Inum, Beneo Synergy 1
- Where
- Slovakia
- Volunteers
- 120 people
- Sponsor
- S&D Pharma SK s.r.o.
Pain, Injection Site Reaction
Safety of Pediatric COVID-19 Vaccination
This is a prospective, observational study. During the study, children and adolescents (ages ≥ 5 to < 16) will be followed post administration of mRNA COVID-19 vaccines.
- Conditions
- Pain, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05157191
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Duke University
Ebola Virus Disease
Observational Study of the Clinico-biological Evolution and Standard of Care Offered to Patients With Ebola Virus Disease
This study highlighted the possibility, even in epidemic settings, of providing advanced supportive care for patients with VMEs.
- Trial name
- EVISTA (NCT04815174)
- Testing
- Standard of Care
- Where
- Democratic Republic of the Congo
- Volunteers
- 711 people
- Sponsor
- Alliance for International Medical Action
Rheumatic Heart Disease, Heart Failure
Gliflozins on HF in Regurgitant Rheumatic Heart
The objective of this trial is to detect impact of Gliflozin on patients with heart failure due to reurgitant rheumatic valve disease
- Trial name
- NCT06097585
- Testing
- SGLT2 inhibitor
- Volunteers
- 150 people
- Sponsor
- Assiut University
Fever, Pain
Bioequivalence Study of Paracetamol With Oral Single Dose Administration in Healthy Adult Subjects Under Fasting Conditions
This study aims to evaluate the bioequivalence of new formulated orodispersible tablet (ODT) containing 500 milligram (mg) paracetamol in comparison to the European marketed Alvedon (paracetamol) 500 mg film-coated tablets and…
- Trial name
- NCT06855576
- Testing
- Paracetamol ODT, Alvedon film-coated tablet, Panadol film-coated Tablet
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- HALEON
Ebola Virus Disease
Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola)
The purpose of this study is to evaluate the efficacy and safety of amiodarone in the treatment of patients afflicted with Ebola virus disease.
- Trial name
- EASE (NCT02307591)
- Testing
- Best Supportive Care, Best Supportive Care + Amiodarone
- Sponsor
- Emergency NGO Onlus
FMF, Colchicine Resistance
Colchicine Levels in the Serum of FMF (Familial Mediterranean Fever) Patients
in this study the investigators will measure the colchicine trough levels in 80 FMF patients taking stable doses of colchicine
- Conditions
- FMF, Colchicine Resistance, Colchicine Toxicity
- Trial name
- NCT03210610
- Testing
- colchicine level measurement
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Sheba Medical Center
Urinary Tract Infection
Topical Steroids to Prevent Recurrent Urinary Tract Infections in Uncircumcised Male Infants: a Pilot Study
The goal of this smaller clinical trial is to evaluate the study design of this research to help prepare for a larger research study in the future.
- Trial name
- STRUMI-T (NCT07508124)
- Testing
- betamethasone valerate 0.1% cream
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Seasonal Allergic Rhinitis
Pilot Study to Evaluate Ear Acupressure Effects in Treating Seasonal Allergic Rhinitis
We hypothesize that ear acupressure will be effective in treating seasonal allergic rhinitis by changing the immune parameters and the psychological impact factors are associated with ear acupressure treatment outcome.
- Trial name
- NCT01921348
- Testing
- acupressure pellets
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy
Anesthesia Management in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
A combined approach of cytoreductive surgery (SRC) and hyperthermic intraperitoneal chemotherapy (HIPEC) represents a potential treatment option for patients diagnosed with primary or secondary gastrointestinal or gynaecological…
- Conditions
- Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Anesthesia
- Trial name
- NCT06398678
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Allergic Rhinitis
Standardising Nasal Allergen Challenge in Adult With Hay Fever
Hay fever affects 1 in 4 of the UK population and has significant effects on the quality of life of sufferers. Allergy to grass pollen is the most common cause.
- Trial name
- NCT04078009
- Testing
- Aquagen, Grazax
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Dengue Fever, Dengue Hemorrhagic Fever
Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule
The aim of the study was to assess and describe the booster effect of a tetravalent CYD dengue vaccine dose administered about 5 years or more after the completion of a 3-dose vaccination schedule in Singapore.
- Trial name
- NCT02824198
- Testing
- CYD Dengue Vaccine (5 dose formulation)
- Where
- 3 sites in Singapore
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Ovarian Cancer
Short-course HIPEC in Advanced Epithelial Ovarian Cancer
This is an open-label, multicenter, single-arm, feasibility phase 2 trial on safety and efficacy of short-course regimen of intra-operative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at the time of fast-track interval…
- Trial name
- NCT02249013
- Testing
- Cytoreductive Surgery (CRS), Hyperthermic Intraperitoneal Chemotherapy (HIPEC), Neoadjuvant Chemotherapy (NACT)
- Volunteers
- 15 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Long Term, Quality of Life
Long-Term Quality Of Life And Symptom Assessment Among Recurrence-Free Patients Who Underwent Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
To evaluate long-term quality of life (QoL) and participant reported symptom burden in disease-free survivors who have undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) at MD Anderson…
- Conditions
- Long Term, Quality of Life, Recurrence Free, Cytoreductive Surgery
- Trial name
- NCT07871760
- Testing
- Questionnaire and Physical Exam
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- M.D. Anderson Cancer Center
Fever, Malaria
Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers
This study is part of a larger prospective cohort study (JOKA), designed to study the incidence and etiological spectrum of febrile illness occurring during a travel to the tropics, as well as clinical course, care, treatment and…
- Trial name
- JOKA-I (NCT02900079)
- Testing
- rapid diagnostic test for malaria antigen
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Q Fever
Safety Evaluation of a Q-fever Vaccine, NDBR 105
The purpose of this study is to evaluate the safety of Q Fever vaccine, NDBR 105, and collect data on incidence of occupational Q Fever infection in at risk personnel.
- Trial name
- NCT00584454
- Testing
- Q Fever Vaccine (NDBR 105
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Gastric Cancer (GC), HIPEC
Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Gastric Cancer
The study investigates the outcomes of hyperthermic intraperitoneal chemoperfusion (HIPEC) in combination with curative-intent gastrectomy in resectable locally-advanced and limited-metastatic (low peritoneal cancer index)…
- Conditions
- Gastric Cancer (GC), HIPEC, Peritoneal Metastases From Gastric Cancer, Hyperthermic Intraperitoneal Chemoperfusion
- Trial name
- G-PEC (NCT07313579)
- Testing
- curative-intent surgery + HIPEC
- Where
- Ukraine
- Volunteers
- 200 people
- Sponsor
- Ukrainian Society of Clinical Oncology
Febrile Morbidity, Pain
Post-Operative Treatment With Ketorolac After Abdominal Myomectomy
The purpose of this study is to determine if ketorolac, given after abdominal myomectomy, will decrease the frequency of post-oerative fevers as well as improve post-operative pain management.
- Trial name
- NCT00845754
- Testing
- ketorolac, saline
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ascher-Walsh, Charles, M.D.
Familial Mediterranean Fever (FMF )
Physical Activity in Adolescents With Familial Mediterranean Fever
Familial Mediterranean Fever (FMF) is one of the most common autoinflammatory rheumatic diseases in childhood. Problems such as joint pain, muscle weakness, decreased aerobic capacity, and fatigue seen in children and adolescents…
- Trial name
- NCT06974942
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Carpal Tunnel Syndrome (CTS), Hyperthermia
Analysis of Hyperthermia as a Complementary Treatment to Evidence-based Clinical Intervention in Subjects With Carpal Tunnel Syndrome:
This project aims to analyze the use of hyperthermia within a treatment protocol for Carpal Tunnel Syndrome (CTS), as well as to determine the difference between two and three sessions per week.
- Conditions
- Carpal Tunnel Syndrome (CTS), Hyperthermia, Frequency of Therapy
- Trial name
- NCT06942273
- Testing
- hyperthermia, physical exercise, splint
- Volunteers
- 160 people
- Sponsor
- University of Malaga