Clinical trials: QT-prolongation
Long QT Syndrome
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
The purpose of this study is to determine whether late sodium channel blockade might be effective in shortening the QTc interval in various LQT3 mutations and be considered as a safe therapeutic option for LQT3 patients.
- Trial name
- NCT01648205
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Long QT Syndrome
Low Cost QTc Meter for Long QT Syndrome Screening in Primary Care
The purpose of this study is to further develop and evaluate a diagnostic procedure suitable for use in an inexpensive diagnostic instrument suitable for screening for Long QT Syndrome (LQTS) in the primary care environment.
- Trial name
- NCT04441892
- Testing
- QTc Meter
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
Acquired Long QT, Ventricular Arrhythmias
Do QT-Prolonging Drugs Cause Major Adverse Cardiac Events in Hospitalized Adults?
There are 28 non-cardiology medications from multiple families costing more than $13 billion annually in Canada, categorized as 'Known' QT-prolonging medications (QTPmeds) based on very low levels of evidence.
- Conditions
- Acquired Long QT, Ventricular Arrhythmias, Torsades de Pointes, Syncope
- Trial name
- QTP-MACE (NCT07374263)
- Where
- 2 sites in Canada
- Volunteers
- 990,000 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Inherited Cardiac Arrhythmias, Long QT Syndrome
Long Term Monitoring for Risk of Sudden Death
Risk prediction in in inherited heart rhythm conditions that may cause sudden cardiac arrest or death is difficult. Sometimes the risks may be low but the loss of life in an otherwise healthy young individual is catastrophic.
- Conditions
- Inherited Cardiac Arrhythmias, Long QT Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy, Brugada Syndrome
- Trial name
- NCT04124237
- Where
- Canada
- Volunteers
- 1,051 people
- Sponsor
- University of British Columbia
Long QT Syndrome, Brugada Syndrome
Physical Activity in Children With Inherited Cardiac Diseases
Use lay language. Current guidelines regarding physical activity in patients with inherited arrhythmia and cardiomyopathy are mostly dedicated to adult patients, with a special focus on sports competition.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Hypertrophic Cardiomyopathy
- Trial name
- NCT04650009
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Long QT Syndrome, Familial Hypercholesterolemia
Comparing Direct vs Indirect Methods for Cascade Screening
An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening.
- Conditions
- Long QT Syndrome, Familial Hypercholesterolemia, Ethics, Genetic Testing
- Trial name
- NCT05348564
- Testing
- Direct contact of family members for cascade screening of relevant variants
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, Baltimore
Long QT Syndrome
QT Measurement Techniques and Anesthesia Management
In studies, the effects of drugs used for anesthesia and analgesia on QT distance were evaluated in isolation. However, drugs are administered in combination with each other during anesthesia induction.
- Trial name
- NCT04706104
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Eating Disorders, Mood Disorders in Children and Adolescents
Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population
Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal.
- Conditions
- Eating Disorders, Mood Disorders in Children and Adolescents, Psychotic Disorder, QTc Intervals Changes
- Trial name
- NCT06870006
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Cardiac Toxicity
Race Difference Moxifloxacin-induced QT Prolongation Between Healthy Chinese and Caucasian Volunteers
A double-center, randomized, double-blinded, 2-way crossover, placebo-controlled Study: Comparison of single oral dose 400mg Moxifloxacin-induced QT prolongation between healthy Chinese volunteers and Caucasian Volunteers Study…
- Trial name
- NCT02119091
- Testing
- Moxifloxacin
- Where
- 2 sites in United States, China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Haiyan Li
Healthy
A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers
The purpose of this study is to determine the safety and tolerability profile of tramadol hydrochloride (HCl) given as oral doses every 6 hours, within the range of dosages supported by currently available toxicology and clinical…
- Trial name
- NCT01947920
- Testing
- Tramadol HCl, 50 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Janssen Scientific Affairs, LLC
Prolonged QT Interval
Effects Rapid Atrial Pacing Has on the Electrocardiogram (ECG) in Patients With Dual Chamber Pacemakers
The purpose of this study is to learn what effect rapid atrial pacing (in patients with dual chamber pacemakers) will have on the electrocardiogram including the QT Interval.
- Trial name
- NCT00883610
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Arrhythmia
The Effect of General Anesthesia on the Risk for Arrhythmia
Polymorphic ventricular tachycardia, known as Torsades de Pointes (TdP), is a specific form of ventricular arrhythmia with a characteristic twist of the QRS complex around the isoelectric baseline.
- Trial name
- 10-02725 (NCT01174251)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Long QT Syndrome
Effect of Grapefruit on QT Interval in Healthy Volunteers and Patients With Congenital Long QT Syndrome
The list of medications that prolong the QT interval and can provoke torsade de pointes keeps expanding. This list includes not only antiarrhythmic drugs, but also medications with no cardiac indications.
- Trial name
- NCT02680080
- Testing
- Moxifloxacin, Grapefruit group
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center