Clinical trials: QTc Interval
Diabetes, Diabetes Mellitus, Type 2
Effect of Liraglutide on Heart Frequency in Healthy Volunteers
This trial is conducted in the United States of America (USA). The aim of this trial is to investigate if liraglutide effects the QTc interval. Moxifloxacin (Avelox®) is administered as positive control.
- Trial name
- NCT01516255
- Testing
- liraglutide, moxifloxacin, electrocardiogram (ECG)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy Subjects
Evaluate the Effect of TPN171H on the QT/QTc Interval in Healthy Volunteers
This is a single-dose orally administered, dose-escalation, single-center, randomized, double-blind, placebo-parallel controlled clinical study evaluating the effect of TPN171H tablets on QT/QTc interval in healthy subjects.The…
- Trial name
- NCT05750355
- Testing
- TPN171H 10 mg Group, TPN171H 30 mg Group, TPN171H 40 mg Group
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Health Adult Subjects
A TQTc Study for Omaveloxolone
This is a randomized, double blind, placebo and active (moxifloxacin open label) controlled study in healthy subjects to assess the effect of the supratherapeutic exposure of omaveloxolone on QTc interval.
- Trial name
- NCT05927649
- Testing
- Omaveloxolone, Moxifloxacin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biogen
Healthy Volunteers
A QT/QTc Evaluation Study of TS-172 in Healthy Adult Subjects
A clinical study to evaluate the effects on QT/QTc interval of TS-172 in healthy adults subjects
- Trial name
- NCT06837155
- Testing
- TS-172 20 mg, TS-172 90 mg, Moxifloxacin
- Where
- Japan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Neoplasm
Effect of Tusamitamab Ravtansine on QTc Interval in Participants With Metastatic Solid Tumors
This is a Phase1, single-arm study for treatment. This is a prospective multicenter, multinational, open-label study to assess the effect of tusamitamab ravtansine on the QT interval in participants with metastatic colorectal…
- Trial name
- TusaRav-QT (NCT05429762)
- Testing
- Tusamitamab ravtansine
- Where
- 7 sites in United States, Belgium and 3 more
- Volunteers
- 56 people
- Sponsor
- Sanofi
Healthy Subject
Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
This is A Randomized, Blinded, Placebo- and Positive-Controlled, Four-Period, Crossover-Design Thorough QT/QTc (TQT) Study to Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
- Trial name
- NCT05660720
- Testing
- Orelabrutinib, Moxifloxacin hydrochloride
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Healthy Volunteers
Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers
This is a single-center, multiple-dose, randomized, double-blind, double-dummy, placebo-controlled, active-comparator, parallel study in healthy volunteers.
- Trial name
- NCT01689116
- Testing
- Bardoxolone Methyl 20mg, Bardoxolone Methyl 80mg, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Biogen
Neoplasms, Cardiac Arrhythmia
Beat to Beat A Study in Paediatric, Adolescent and Young Adult Patients Who Are Undergoing or Have Undergone Cancer Therapy to Evaluate the Agreement Between QTc Measured Using 12 Lead Electrocardiogram (ECG) and a Wearable Device ECG
A prospective study in paediatric, adolescent and young adult patients aged 7 to 18 years to evaluate the agreement between QTc measured using 12 lead electrocardiogram (ECG) and the wearable device ECG.
- Trial name
- NCT05615376
- Testing
- ECG application, 12 lead ECG
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Murdoch Childrens Research Institute
Dyslipidemia
A Thorough Corrected QT Interval Trial
The purpose of this study is to determine the effects of K-877 on ECG parameters with a focus on cardiac repolarization compared with placebo in healthy adult subjects.
- Trial name
- NCT02073084
- Testing
- K-877 Low Dose, Moxifloxacin, K-877 High Dose
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Healthy
Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in Healthy Subjects
This is a Phase 1, randomized, double-blind (except for moxifloxacin), placebo- and positive-controlled, single-site, 4-way crossover study to investigate the effects of single therapeutic and supratherapeutic IV doses of…
- Trial name
- NCT04019574
- Testing
- CR845 0.5 mcg/kg IV, CR845 3 mcg/kg IV, Moxifloxacin 400 mg Oral Tablet
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cara Therapeutics, Inc.
Anemia
A Study of the Electrocardiogram Effects and Pharmacokinetics of Ferumoxytol in Healthy Men and Women
This study will define the effects of ferumoxytol on electrocardiogram (ECG) data as well as evaluate pharmacokinetics
- Trial name
- NCT00360425
- Testing
- ferumoxytol, moxifloxacin
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- AMAG Pharmaceuticals, Inc.
Coronary Artery Disease
Study to Evaluate the QT / QTc Interval Prolongation Potential of Vericiguat
The primary objective of this study was to investigate whether there is a clinically meaningful effect on QTc change from baseline relative to placebo after administration of 10 mg at steady state in patients with stable CAD…
- Trial name
- NCT03504982
- Testing
- Vericiguat (BAY1021189), Moxifloxacin
- Where
- 8 sites in Germany, Moldova and 1 more
- Volunteers
- 74 people
- Sponsor
- Bayer
Carcinoma, Renal Cell
VEG111485: A QTc Study of Pazopanib
This is a Phase I, randomized, double-blind, placebo-controlled, study to estimate the effects of daily oral dosing of 800 mg pazopanib on electrocardiographic parameters (QTc interval duration) as compared with placebo in…
- Trial name
- NCT00861029
- Testing
- Pazopanib, Moxifloxacin
- Where
- 8 sites in United States
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Advanced Cancer
Study to Evaluate the Effect of Cetuximab on Corrected QT (QTc) Interval Changes in Patients With Advanced Malignancies From Solid Tumors
The purpose of this study is to determine whether corrected QT (QTc) interval changes occur on an electrocardiogram (ECG) when cetuximab is administered to the study population.
- Trial name
- NCT00698841
- Testing
- Cetuximab
- Where
- 16 sites in United States, Puerto Rico
- Volunteers
- 79 people
- Sponsor
- Eli Lilly and Company
Healthy
A Study to Evaluate the PF-06700841 Effect on QTc Interval in Healthy Volunteers
A phase 1, 6-sequence, 3-period, subject- and investigator blinded and sponsor-open, crossover study in healthy volunteers to evaluate the PF-06700841 effect on QTc interval.
- Trial name
- NCT03656952
- Testing
- PF-06700841, moxifloxacin
- Where
- Belgium
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pfizer
Solid Tumor, Adult
To Assess the Effects of Single Dose of JMKX001899 on QTc Interval in Healthy Subjects
Study to assess the effect of JMKX001899 on QTc interval in healthy volunteers
- Trial name
- NCT06473948
- Testing
- JMKX001899
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Jemincare
Healthy
Assess the Effect of Cangrelor at the Therapeutic Dose and a Supratherapeutic Dose Level on the QT/QTc Interval in Healthy Volunteers
To assess the safety of cangrelor on cardiac repolarization as measured by electrocardiogram (ECG) at therapeutic and supratherapeutic doses.
- Trial name
- NCT00699504
- Testing
- cangrelor, moxifloxacin
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- The Medicines Company
Disorder Related to Lung Transplantation
QT-Prolongation in Lung Transplantation
Experimental intervention: electrocardiography. Control intervention: none Duration of intervention per patient/subject: 5 min, observation 6 months Key inclusion criteria: outpatients after lung transplantation (single, double…
- Trial name
- TX-QTC (NCT02380365)
- Testing
- Electrocardiography
- Where
- Germany
- Volunteers
- 720 people
- Sponsor
- Hannover Medical School
Healthy Subjects
Study to Evaluate the Effect of a Single Oral Dose of MT-7117 on the QT/QTc Interval in Healthy Subjects
The purpose of this study is to evaluate the effect of a single oral dose of MT-7117 on the QT/QTc interval in healthy subjects.
- Trial name
- NCT05241535
- Testing
- MT-7117, moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma America, Inc.
Healthy
Effect of Anagrelide Hydrochloride on Any Changes in Heart Function in Healthy Volunteers
According to the ICH Guidance Document E14, all non-antiarrhythmic drugs should be evaluated for their ability to prolong the QT interval which represents the duration of ventricular depolarization and subsequent repolarization.
- Trial name
- NCT01552928
- Testing
- Anagrelide 0.5 mg, Anagrelide 2.5 mg, Moxifloxacin
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shire