Clinical trials: Quadriplegia
Spinal Cord Injury, Tetraplegia
Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury
The purpose of this study is to determine if tetraplegic individuals with incomplete spinal cord injury (SCI) who remain unable to move their arms normally 1 year after their SCIs are able to sense and move the affected arm(s)…
- Conditions
- Spinal Cord Injury, Tetraplegia, Paresis, Plegia
- Trial name
- NCT00833105
- Testing
- AMES treatment
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
Consciousness Disorders, Locked-In Syndrome
Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome
The primary aims of this study are: 1. To determine the feasibility of deploying mindBEAGLE, a portable, bedside EEG-based system, in the Intensive Care Unit in patients with disorders of consciousness (DOC) or locked-in syndrome…
- Trial name
- NCT02772302
- Testing
- mindBEAGLE EEG-based brain-computer interface
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injury, Respiratory Muscle Weakness
Albuterol to Improve Respiratory Strength in SCI
Spinal cord injury (SCI), especially involving the cervical and upper thoracic segments, can significantly compromise respiratory muscle function.
- Trial name
- NCT02508311
- Testing
- Oral Albuterol Extended Release
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Orthostatic Hypotension, Spinal Cord Injury
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects…
- Trial name
- NCT00835224
- Testing
- L-NAME, Midodrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury, Paraplegia
Spinal Cord Injury Leg Rehabilitation
The purpose of this study is to determine if individuals with incomplete spinal cord injury (SCI) who remain unable to walk normally 1 year after their SCIs are able to sense and move the affected legs better after 10-13 weeks of…
- Conditions
- Spinal Cord Injury, Paraplegia, Quadriplegia, Tetraplegia
- Trial name
- AMES (NCT01498991)
- Testing
- AMES Treatment
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Functional Neuroimaging
Sensorimotor Imaging for Brain-Computer Interfaces
The investigators will use fMRI to map movement activity in motor and somatosensory cortex using enriched imagery in people with chronic tetraplegia.
- Trial name
- NCT04723823
- Testing
- Motor or sensory imagery with fMRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Locked-In Syndrome
First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
In this study a new means of communication for people with locked-in syndrome will be tested. The investigators will record brain signals directly from the surface of the brain by means of a completely implantable system.
- Trial name
- UNP (NCT02224469)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- UMC Utrecht
Spinal Cord Injuries, Paraplegia, Spinal
Transspinal Stimulation Plus Locomotor Training for SCI
Locomotor training is often used with the aim to improve corticospinal function and walking ability in individuals with Spinal Cord Injury.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
- Trial name
- NCT04807764
- Testing
- Standing transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- City University of New York
Hypotension, Spinal Cord Injury
Prevention of Low Blood Pressure in Persons With Tetraplegia
The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while…
- Trial name
- NCT00237770
- Testing
- N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Tetraplegia, Asthma
Exhaled Levels of Nitric Oxide
Previously it was observed that individuals with tetraplegia have reduced baseline airway caliber and exhibit non-specific airway hyperresponsiveness (AHR).
- Trial name
- NCT00753948
- Testing
- N-Nitro L-arginine-methylester (L-NAME)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Quadriplegia, Spinal Cord Injury
Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis
This study was intended to evaluate a new assistive neuro-technology, known as the Tongue Drive System (TDS), by its potential end-users, i.e.
- Conditions
- Quadriplegia, Spinal Cord Injury, ALS
- Trial name
- TDS-1 (NCT01124292)
- Testing
- Tongue Piercing, Usability assessment
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Spinal Cord Injury at C4-C6 Level
High Definition Neuromuscular Stimulation in Tetraplegia
The purpose of this study is to demonstrate high definition non-invasive neuromuscular stimulation of an upper extremity in tetraplegic participants.
- Trial name
- NCT04075812
- Testing
- Neuromuscular Stimulator
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ohio State University
Paraplegia, Tetraplegia
Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
A study comparing short-term delivery of epidural spinal stimulation versus transcutaneous spinal stimulation.
- Conditions
- Paraplegia, Tetraplegia, Paralysis, Quadraplegia
- Trial name
- NCT05095454
- Testing
- Percutaneous epidural electrical spinal stimulation, Transcutaneous electrical spinal stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristin Zhao, PhD
Tetraplegia, Hypothermia
Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
The ability to maintain normal core body temperature (Tcore = 98.6°F) is impaired in persons with a cervical spinal cord injury (tetraplegia).
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02379156
- Testing
- Midodrine Hydrochloride, Cool Temperature
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Tetraplegia
Hand Function for Tetraplegia
The purpose of this study is to evaluate the effectiveness of an implanted stimulator for providing hand function to individuals with cervical level spinal cord injury.
- Trial name
- NCT00890916
- Testing
- FIRSTHAND System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Paraplegia
Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI
The primary objective of this study is to achieve successful walking skills using exoskeletal walking devices over the course of 36 sessions in 3 months at specific velocities and distances in people with chronic SCI who are…
- Conditions
- Spinal Cord Injury, Paraplegia, Tetraplegia
- Trial name
- EAWSCI (NCT02314221)
- Testing
- Exoskeletal-assisted walking (ReWalk, Ekso)
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development