Clinical trials: Quantification
Hemiplegia
Quantification of Arm Non-Use After a Stroke
Reproducibility assessment of a quantitative measure of the amount of trunk compensation by kinematic analysis in a grasping task in stroke patients.This "maladaptive trunk compensation" is suspected to be underlined by "arm…
- Trial name
- NCT02326688
- Testing
- Kinematic analysis of trunk compensation
- Where
- France
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sleep-Disordered Breathing
Incorporating Flow Limitation Into the Diagnosis and Quantification of Sleep Disordered Breathing
The diagnosis and treatment of sleep disordered breathing have come to the forefront of clinical medicine following recognition of the high prevalence and associated morbidity of sleep apnea.
- Trial name
- NCT00004569
- Testing
- Non-invasive technique to diagnose and quantitate sleep-disordered breathing
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
PArs Plana Vitrectomy, Retinal Detachment
Quantification of Silicone Oil Emulsification After Pars Plana Vitrectomy
silicone oil tamponade removal after previous injection of complicated retinal detachment can be achieved with active suction followed by triple air-fluid exchange or prolonged lavage of the vitreous chamber to remove…
- Conditions
- PArs Plana Vitrectomy, Retinal Detachment, Silicone Oil Droplets on Intraocular Lens
- Trial name
- NCT04774146
- Testing
- pars plana vitrectomy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ospedale Policlinico San Martino
Breast Neoplasms
Assessment of Response to Neo-adjuvant Chemotherapy for Patients With a Locally Advanced Breast Cancer With 3D Elastography (Shear Wave), NEOELASTO
Assess the accuracy of the sequential measurements by 3D Shear Wave Elastography (SWE) for predicting histological response to neoadjuvant chemotherapy in patients with locally advanced breast cancer.
- Trial name
- NEO-ELASTO (NCT02834494)
- Testing
- 3D Shear Wave Elastography (SWE), Biopsy
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Institut Curie
Coronary Artery Disease
Ultra-low-dose CACS in a Large Population
Radiation exposure to patients from CT for CAC scoring has steadily decreased in recent years. This is mainly achieved through lowering tube currents alongside with the introduction of iterative reconstruction algorithms which…
- Trial name
- ULDCACSLARGE (NCT03637231)
- Testing
- Ultra low-dose CTAC
- Where
- Switzerland
- Volunteers
- 301 people
- Sponsor
- University of Zurich
Multiple Sclerosis
Novel Immune Markers in Patients With Multiple Sclerosis
The investigators hypothesize that the endogenous cannabinoid signalling system has lost homeostasis in the disease multiple sclerosis (MS).
- Trial name
- NIMMS (NCT01026272)
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Solid Tumor
PET Study With [89Zr]-Df-CriPec® Docetaxel
A clinical phase I, open-label PET study with [89Zr]-Df-CriPec® docetaxel in patients with solid tumours to assess biodistribution and tumour accumulation of [89Zr]-Df-CriPec® docetaxel.
- Trial name
- NCT03712423
- Testing
- Cripec Docetaxel
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Amsterdam UMC, location VUmc
Reproductive Disorder, Neurodegeneration
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome.
- Conditions
- Reproductive Disorder, Neurodegeneration, SARS-CoV 2, Long COVID
- Trial name
- NCT07224490
- Testing
- Kisspeptin 112-121
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stephanie B. Seminara, MD
Parkinson's Disease
Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease
Levodopa is the main drug treatment for Parkinson's disease. Levodopa can cause unwanted and uncontrolled movements called dyskinesias. A drug called amantadine can reduce these movements.
- Trial name
- NCT00794313
- Testing
- Amantadine 300 mg, Topiramate, Sugar Pill
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Oregon Health and Science University
Ebola Virus Disease
Immunology of Ebola Vaccine
In this study 30 healthy adult participants will receive a single dose of an Ebola vaccine. Blood samples, fine needle aspirates, core biopsies, and bone marrow aspirates will be collected prior to and following vaccination to…
- Trial name
- NCT06100913
- Testing
- Recombinant Vesicular Stomatitis Vaccine for Ebola (rVSV∆G-ZEBOV-GP), Deuterium Labeled Water
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Glioblastoma Multiforme, Glycolytic Index
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors.
- Conditions
- Glioblastoma Multiforme, Glycolytic Index, Epidermal Growth Factor Receptor
- Trial name
- NCT06059690
- Testing
- pH Measurement of in vivo tissue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Physiological Stress
Physiologic Burden to the Surgeon During Orthopaedic Surgery
The investigator's plan to quantify the physiologic impact of orthopaedic surgery on the surgeon and operating team.
- Trial name
- NCT06180044
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Utah
Anemia of Prematurity, Necrotizing Enterocolitis
Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates
Despite many advances in neonatal care, necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality among premature infants.
- Trial name
- NCT01735552
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Periodontal Diseases, Coronary Artery Disease
Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects
Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease.
- Trial name
- NCT04127487
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Coronary Artery Disease
Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying…
- Trial name
- NCT00921440
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Huntington Disease
Dosimetry of [11C]CHDI-180R and [11C]CHDI-626.
A better understanding of the HD pathogenesis mechanisms may lead to a better understanding of disease pathology, progression and development of targeted therapies.
- Trial name
- NCT05224115
- Testing
- [11C]CHDI-00485180-R, [11C]CHDI-00485626
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Myopathy, Muscular Dystrophies
Muscle Health Measurements Using Electrical Impedance Myography
This study is being done to further develop a device, the mScan, to measure muscle health as compared to measurements of muscle health using MRI (magnetic resonance imaging).
- Conditions
- Myopathy, Muscular Dystrophies, Myositis, Myofibrillar Myopathy
- Trial name
- NCT07502989
- Testing
- Electrical Impedance Myography
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Spinocerebellar Ataxia
Wearable Gait Sensors
This research study is testing body-worn sensors to measure movement during simple tests of coordination, in order to evaluate the progression and severity of Spinocerebellar ataxia.
- Trial name
- NCT06628934
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Tooth Erosion
In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole
Dental erosions in 30 male and female patients with proven abnormal gastrooesophageal reflux will be assessed clinically and using a novel optical coherence tomography (OCT) laser technique before and after double-blind…
- Trial name
- NCT00564330
- Testing
- Esomeprazole
- Volunteers
- 30 people
- Sponsor
- Brain-Gut Research Group
Anesthesia Awareness
Heart Rate Variability to Quantify General Anesthesia Depth
The shortage of anesthetic agents can lead to intraoperative awareness while overdosing can trigger severe intra and postoperative problems.
- Trial name
- NCT04788732
- Testing
- ECG and EEG monitoring
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo