Clinical trials: RA - Rheumatoid Arthritis
Rheumatoid Arthritis
Evaluate the Safety, Tolerability, Pharmacokinetics,and Clinical Activity of FB704A
The cause of Rheumatoid Arthritis (RA) is not fully understood. However, one of the substances secreted by certain cells in the body, interleukin-6 (IL-6), is believed to play a major role in chronic inflammation that is typical…
- Trial name
- NCT03890302
- Testing
- FB704A
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Fountain Biopharma Inc.
Systemic Lupus Erythematosus, Rheumatoid Arthritis
Early Clinical Study of UTAA91 Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
This clinical trial is designed as a single - arm, open - label, single - center, investigator - initiated early - phase clinical study.
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis, Dry Syndrome, Idiopathic Inflammatory Myopathies
- Trial name
- NCT06970951
- Testing
- UTAA91 injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Rheumatoid Arthritis
Adalimumab in Combination With Methotrexate vs Methotrexate Alone in Early Rheumatoid Arthritis
The purpose of the study is to evaluate the effectiveness of adalimumab in combination with methotrexate compared to methotrexate alone on work disability in subjects with early rheumatoid arthritis
- Trial name
- NCT00234845
- Testing
- adalimumab, methotrexate
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Abbott
Rheumatoid Arthritis, Juvenile
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis
The purpose of this study is to evaluate the effectiveness and safety of infliximab (Remicade) in patients with Juvenile Rheumatoid Arthritis (JRA).
- Trial name
- NCT00036374
- Testing
- Infliximab
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Autologous Adipose Tissue Stromal Vascular Fraction Cells for Rheumatoid Arthritis
Autologous stromal vascular fraction (SVF) injected at 8 and 10 days after extraction is safe and useful procedure in inducing remission of RA in patients resistant to standard DMARD therapy.
- Trial name
- NCT01885819
- Testing
- Autologous stromal vascular fraction cells
- Where
- Panama
- Sponsor
- Translational Biosciences
Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA)
A Study to Evaluate the Safety and Activity of SAR448501/DR-0201 in Patients With Autoimmune Rheumatic Diseases
This is an open-label, multi-ascending dose (MAD) phase 1 study, with dose expansion at selected doses, in adult patients with select autoimmune rheumatic diseases including systemic lupus erythematosus (SLE) or rheumatoid…
- Trial name
- NCT06647069
- Testing
- SAR448501
- Where
- 8 sites in Australia, Bosnia and Herzegovina and 3 more
- Volunteers
- 62 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
An Observational Study in Rheumatoid Arthritis Patients Treated With RoActemra/Actemra (Tocilizumab)
This multi-center, observational study will evaluate the clinical practice patterns, efficacy and safety of RoActemra/Actemra (tocilizumab) in patients with rheumatoid arthritis.
- Trial name
- NCT01565122
- Where
- 10 sites in Finland
- Volunteers
- 51 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening
To compare the maintenance of efficacy of the combination of etanercept 50 mg once weekly plus methotrexate with or without other disease modifying antirheumatic drugs therapy with that of methotrexate with or without other…
- Trial name
- NCT01578850
- Testing
- Etanercept
- Where
- 62 sites in Brazil, China and 17 more
- Volunteers
- 491 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Multiple-dose Study of the Safety and Tolerability of REGN88(SAR153191) in Rheumatoid Arthritis Subjects
This is a randomized study of the safety and tolerability of multiple doses of REGN88 in rheumatoid arthritis patients who are receiving treatment with methotrexate.
- Trial name
- NCT01011959
- Testing
- REGN88
- Where
- 24 sites in United States
- Volunteers
- 60 people
- Sponsor
- Regeneron Pharmaceuticals
Rheumatoid Arthritis
A Study to Assess the Effect of Tocilizumab + Methotrexate on Prevention of Structural Joint Damage in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA)
This 3 arm study will compare the safety and efficacy, with respect to a reduction in signs and symptoms and prevention of joint damage, of tocilizumab versus placebo, both in combination with methotrexate (MTX) in patients with…
- Trial name
- NCT00106535
- Testing
- tocilizumab [RoActemra/Actemra], Methotrexate
- Where
- 152 sites in United States, Australia and 14 more
- Volunteers
- 1,196 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Phase 2 Study to Evaluate the Efficacy and Safety of 60mg of MM-093 in Patients With Active Rheumatoid Arthritis
The purpose of this study is to determine whether MM-093 is safe and effective in the treatment of RA.
- Trial name
- NCT00458146
- Testing
- MM-093
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Merrimack Pharmaceuticals
Arthritis, Rheumatoid
Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) Patients
This study is to evaluate available local data in Iraqi patients with rheumatoid arthritis on Enbrel treatment with regards to the impact of Rheumatoid factor and Anti-cyclic citrullinated peptide using data from the Baghdad…
- Trial name
- NCT04428424
- Testing
- Enbrel
- Where
- Iraq
- Volunteers
- 1,493 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Trial With HuMax-CD4 in Participants With Rheumatoid Arthritis (RA) Failing Treatment With Methotrexate (MTX) and a TNF-alpha Blocker
The purpose of this study is to determine whether HuMax-CD4 is effective in the treatment of active RA in participants who have failed treatment with MTX and at least one TNF-alpha blocking agent.
- Trial name
- NCT00042406
- Testing
- HuMax-CD4
- Where
- 54 sites in United States, Canada
- Volunteers
- 83 people
- Sponsor
- Genmab
Rheumatoid Arthritis
Effectiveness and Safety of Adalimumab in Rheumatoid Arthritis Patients in Routine Clinical Practice
Observation of safety, tolerability and effectiveness of adalimumab (Humira) therapy in a large patient collective under everyday clinical conditions over a 5-year period.
- Trial name
- NCT01078090
- Where
- 370 sites in Germany
- Volunteers
- 5,745 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Rheumatoid Arthritis
Sarilumab Effect on the Pharmacokinetics of Simvastatin
Primary Objective: To evaluate the effect of a single 200 mg subcutaneous injection of sarilumab on the pharmacokinetics of simvastatin in patients with rheumatoid arthritis Secondary Objective: To describe the safety and…
- Trial name
- NCT02017639
- Testing
- sarilumab SAR153191 (REGN88), simvastatin
- Where
- 5 sites in United States, Moldova and 1 more
- Volunteers
- 19 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
An Exploratory Study of Changes in Synovial Immune Responses Following BMS-188667 Therapy in Subjects With Active Rheumatoid Arthritis on Background DMARDs Who Have Failed Anti-TNF Therapy
Study to assess changes in synovial tissue before and after treatment with Abatacept in subjects with RA who remained on their background disease modifying anti-arthritis medications but who have failed previous therapy with…
- Trial name
- NCT00162201
- Testing
- Abatacept
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA)
Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid Arthritis Patients
This is a Phase III study to evaluate efficacy and safety of Tocilizumab in patients with Rheumatoid Arthritis.
- Trial name
- NCT01258712
- Testing
- Tocilizumab + methotrexate(MTX)
- Where
- 12 sites in Taiwan
- Volunteers
- 86 people
- Sponsor
- Chugai Pharma Taiwan
Rheumatoid Arthritis
A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis.
This single arm study will measure the effect of MabThera in combination with methotrexate on the progression of synovitis, the extent of bone marrow edema, and the number of erosions in the wrist and hand of patients with…
- Trial name
- NCT00502853
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Hoffmann-La Roche
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
A Study to Investigate How JNJ-39758979 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis Participants
The purpose of this study is to evaluate the effects of JNJ-39758979 on the pharmacokinetics (how the body handles a drug) of methotrexate in participants with rheumatoid arthritis.
- Trial name
- NCT01442545
- Testing
- JNJ-39758979 / MTX
- Where
- 5 sites in United States, Germany
- Volunteers
- 21 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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