Clinical trials: RA - Rheumatoid Arthritis
Rheumatoid Arthritis
Anti-Inflammatory Dietary Intervention for Rheumatoid Arthritis
The primary objective of this study is to assess if there is a significant difference in the mean disease activity score in individuals with RA participating in a dietary intervention compared to those in the control group…
- Trial name
- RA-Diet (NCT05291299)
- Testing
- Anti-inflammatory diet, Control/Standard of Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Attune Health Research, Inc.
Rheumatoid Arthritis
Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)
Main Study: Primary Objective: Assess the long term safety of sarilumab in participants with rheumatoid arthritis (RA). Secondary Objective: Assess the long term efficacy of sarilumab in participants with RA.
- Trial name
- NCT01146652
- Testing
- SAR153191 (REGN88)
- Where
- 335 sites in United States, Argentina and 38 more
- Volunteers
- 2,023 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Autologous Adipose-derived Stem Cells (AdMSCs) for Rheumatoid Arthritis
This is an investigational new drug clinical trial for combined Phase 1 dose escalation study and Phase 2a randomized, placebo controlled and double blinded study using intravenous injection of autologous adipose stem cells…
- Trial name
- NCT04170426
- Testing
- autologous adipose derived stem cells
- Volunteers
- 54 people
- Sponsor
- Celltex Therapeutics Corporation
Osteoarthritis, Rheumatoid Arthritis
Descriptive Study in Patients Treated With Vimovo™, Including Registration of the Physicians' Prescribing Patterns
The most common pain-relievers used by patients with rheumatic disorders are called non-steroidal anti-inflammatory drugs (NSAIDs).
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- CHARACTERIZE (NCT01511926)
- Where
- 96 sites in Belgium, Finland and 6 more
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
EMBRACE-SC: Observational Study of Subcutaneous (SC) Tocilizumab Alone or in Combination With Conventional Disease-Modifying Antirheumatic Drugs (cDMARDs) in Rheumatoid Arthritis
The purpose of this study is to evaluate the percentage of participants treated with subcutaneous (SC) Tocilizumab who are still on treatment after 52 weeks and the factors that play a major role in continuation of treatment.
- Trial name
- NCT02648035
- Testing
- Tocilizumab
- Where
- 26 sites in Greece
- Volunteers
- 200 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
Study Evaluating the Efficacy and Safety of Etanercept in Chinese Subjects With Rheumatoid Arthritis
The objective of this study is to compare in Chinese subjects with rheumatoid arthritis (RA) the efficacy and safety in this subject population of 50 mg once-weekly injections of etanercept versus placebo in subjects receiving…
- Trial name
- NCT00443950
- Testing
- Etanercept
- Where
- 6 sites in China
- Volunteers
- 150 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM)
This study will evaluate the efficacy and safety of ocrelizumab, compared with placebo, in combination with methotrexate in patients with active rheumatoid arthritis who are naive to methotrexate.
- Trial name
- FILM (NCT00485589)
- Testing
- Methotrexate, Ocrelizumab
- Volunteers
- 613 people
- Sponsor
- Genentech, Inc.
Rheumatoid Arthritis
A Non-Interventional Study of RoActemra/Actemra (Tocilizumab) Treatment in Patients With Rheumatoid Arthritis
This multicenter, observational study will evaluate the use and efficacy of RoActemra/Actemra (tocilizumab) in routine clinical practice in patients with moderate to severe rheumatoid arthritis.
- Trial name
- NCT01952509
- Where
- 6 sites in Costa Rica, Dominican Republic and 2 more
- Volunteers
- 169 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Psoriatic Arthritis
A Study to Test the Design, Functionality, and Ergonomic Features of the Autoinjector
The main purpose of this study is to evaluate how well the autoinjector works in a group of people who are likely to use the autoinjector for injecting their medicine in the future.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Psoriasis
- Trial name
- NCT00643526
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants
The primary objective of this study is to evaluate the effect of filgotinib on a mixed organic anion transporting polypeptide/cytochrome P450 3A (OATP/CYP3A), OATP/ breast cancer resistance protein (BCRP), and OATP substrates…
- Trial name
- NCT04608344
- Testing
- Atorvastatin, Pravastatin, Rosuvastatin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Rheumatoid Arthritis (RA)
Assessment of Safety, Pharmacokinetics and Efficacy in a Combination Treatment With SMP-114
To compare the efficacy of SMP-114 (120 and 240 mg/d) versus placebo in terms of the percentage of patients meeting the American College of Rheumatology criteria for 20% improvement in RA (ACR20) at week 24.
- Trial name
- NCT00296257
- Testing
- SMP-114
- Where
- 46 sites in Czechia, Germany and 4 more
- Volunteers
- 312 people
- Sponsor
- Dainippon Sumitomo Pharma Europe LTd.
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Rheumatoid Arthritis
Efficacy Study of MM-093 in Rheumatoid Arthritis Patients on Methotrexate (MTX)
The purpose of this clinical study is to see if an experimental drug, called MM-093, is safe and effective in the treatment of rheumatoid arthritis.
- Trial name
- NCT00105976
- Testing
- MM-093
- Where
- 38 sites in United States
- Volunteers
- 260 people
- Sponsor
- Merrimack Pharmaceuticals
Rheumatoid Arthritis
A Phase III Study of Abatacept (BMS-188667) in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate
Short Term: The purpose of this clinical research study is to learn if abatacept (BMS-188667) in combination with methotrexate is better than methotrexate alone in participants that have active rheumatoid arthritis and are not…
- Trial name
- NCT00048568
- Testing
- Abatacept, Methotrexate
- Where
- 48 sites in United States
- Volunteers
- 1,250 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Long-term Treatment Study of Certolizumab Pegol (CDP870) as Add-on Medication to Methotrexate in Japanese Rheumatoid Arthritis (RA) Patients
The objectives of this study are to evaluate the safety and efficacy of certolizumab pegol as add-on medication to methotrexate over the long term in Japanese RA patients transferred from Study 275-08-001 (NCT00791999), and to…
- Trial name
- NCT00851318
- Testing
- Certolizumab pegol, Methotrexate
- Where
- 8 sites in Japan
- Volunteers
- 285 people
- Sponsor
- Astellas Pharma Inc
Arthritis, Rheumatoid
Efficacy and Safety of TAK-783 in Subjects With Rheumatoid Arthritis
The purpose of this study is to determine the efficacy and safety of TAK-783, once daily (QD), taken in combination with methotrexate in subjects with rheumatoid arthritis.
- Trial name
- NCT00760968
- Testing
- TAK-783 and methotrexate, Methotrexate
- Where
- 25 sites in Czechia, Latvia and 4 more
- Volunteers
- 224 people
- Sponsor
- Takeda
Systemic Sclerosis Associated Interstitial Lung Disease, Rheumatoid Arthritis Associated Interstitial Lung Disease (RA-ILD)
A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetic Profile of Genakumab Injection in Patients With Connective Tissue Disease-associated Interstitial Lung Disease
This study was conducted in a randomized, double-blind, placebo-controlled design to evaluate the efficacy and safety of Genakumab injection in the treatment of CTD-ILD including Rheumatoid Arthritis associated Interstitial Lung…
- Conditions
- Systemic Sclerosis Associated Interstitial Lung Disease, Rheumatoid Arthritis Associated Interstitial Lung Disease (RA-ILD), Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)
- Trial name
- NCT06189495
- Testing
- GenSci048
- Where
- 4 sites in China
- Volunteers
- 30 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Hip Osteoarthritis, Noninflammatory Degenerative Joint Disease
Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty.
This is a single center, prospective, randomized controlled study. The primary objective of this study is to measure migration over two years with RSA.
- Conditions
- Hip Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Correction of Functional Deformity
- Trial name
- NCT03409666
- Testing
- Taperloc Complete Microplasty stem, Taperloc Complete Reduced Distal stem
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid Arthritis
The objective of this study is to evaluate the activity of 2 oral doses of AB1010 in subjects suffering from active RA who have shown an inadequate response to one DMARD including MTX or anti-TNF, after 3 months (12 weeks) of…
- Trial name
- NCT00831922
- Testing
- masitinib (AB1010)
- Volunteers
- 43 people
- Sponsor
- AB Science
Osteoarthritis, Rheumatoid Arthritis
Vanguard Complete Knee Versus Vanguard High Flex Rotating Platform (RP) Knee Study
The purpose of this study is to compare Vanguard High Flex Rotating Platform to Vanguard Complete Knee System in Asian population in terms of early range of motion (ROM), clinical outcomes, and kinetic and kinematic…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT01010269
- Testing
- Vanguard Complete Knee, Vanguard High Flex RP
- Where
- 4 sites in South Korea
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
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