Clinical trials: RA - Rheumatoid Arthritis
Rheumatoid Arthritis, Psoriasis
A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Participants and Patients With Average to Very Serious Psoriasis
The purpose of this study is to investigate experimental medication BMS-986251 taken by mouth in healthy patients and patients with average to very serious Psoriasis (a condition characterized by itchy, dry skin with a scaly…
- Conditions
- Rheumatoid Arthritis, Psoriasis, Ankylosing Spondylitis, Inflammatory Bowel Diseases
- Trial name
- NCT03329885
- Testing
- BMS-986251
- Where
- Netherlands
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Efficacy and Safety Study of RoActemra (Tocilizumab) in Participants With Rheumatoid Arthritis
This is an open-label, non-interventional study to evaluate efficacy and safety in rheumatoid arthritis participants receiving tocilizumab as per the product label.
- Trial name
- NCT02721004
- Testing
- Tocilizumab
- Where
- Austria
- Volunteers
- 592 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Co-Administration Of Methotrexate And CP-690,550
This study was designed to estimate the effects of methotrexate (MTX) on the pharmacokinetics (PK) of CP-690,550 when administered to subjects with rheumatoid arthritis (RA), to estimate the effects of CP-690,550 on the PK of MTX…
- Trial name
- NCT01745055
- Testing
- CP-690,550 (tofacitinib), Methotrexate (MTX)
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid Arthritis
CRx-102 is a synergistic combination drug candidate containing the cardiovascular drug dipyridamole and a very low dose of the glucocorticoid prednisolone.
- Trial name
- MARS-1 (NCT00551707)
- Testing
- CRx-102 (2.7/180), prednisolone, dipyridamole
- Where
- 48 sites in United States, Argentina and 10 more
- Volunteers
- 51 people
- Sponsor
- Zalicus
Arthritis, Rheumatoid
HuMax-CD20 in Active Rheumatoid Arthritis, Phase I/II
The purpose of this trial is primarily to investigate the safety profile of HuMax-CD20 in patients with active RA. Furthermore, the trial is designed to identify the dose levels to be used in future trials (based on evaluations…
- Trial name
- NCT00291928
- Testing
- Part A, Part B
- Volunteers
- 201 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
Aminopterin Dose Finding Treatment for Methotrexate-Naïve Rheumatoid Arthritis
The purpose of this study is to determine whether aminopterin is effective in the treatment of rheumatoid arthritis (RA).
- Trial name
- NCT01724931
- Testing
- LD-aminopterin
- Where
- 15 sites in Ukraine
- Volunteers
- 175 people
- Sponsor
- Syntrix Biosystems, Inc.
Rheumatoid Arthritis
SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid Arthritis
The purpose of the study is to determine the efficacy, safety and pharmacokinetics of SC12267 (4SC-101, 35 mg) in combination with methotrexate in comparison to methotrexate alone in the treatment of patients suffering from…
- Trial name
- COMPONENT (NCT01010581)
- Testing
- SC12267 (4SC-101), Methotrexate, Folic Acid
- Where
- 27 sites in Bulgaria, Czechia and 2 more
- Volunteers
- 266 people
- Sponsor
- 4SC AG
Rheumatoid Arthritis
A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa Therapies
This study will assess the long-term safety and efficacy of repeating treatment with MabThera, in combination with methotrexate and steroids, in patients who were previously randomized into MabThera study WA17042.
- Trial name
- NCT02097745
- Testing
- methotrexate, rituximab [MabThera/Rituxan]
- Where
- 97 sites in United States, Belgium and 9 more
- Volunteers
- 341 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Psoriatic Arthritis
Therapeutic Strategy Associated With bDMARDs or tsDMARDs in Rheumatoid Arthritis and Psoriatic Arthritis
This is a longitudinal, observational, prospective, multicentre study conducted in France, among a representative sample of rheumatology doctors.
- Trial name
- STRATEGE2 (NCT05082805)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nordic Pharma SAS
Rheumatoid Arthritis
Cost Utility Analyses of Adalimumab Treatment in Patients With Rheumatoid Arthritis (RA)
Evaluation of Health Related Quality of Life (HRQL) is of a paramount importance in assessing the impact of rheumatoid arthritis on patients' health status, however when costs associated with rheumatoid arthritis are also taken…
- Trial name
- HEOR (NCT01078116)
- Where
- 10 sites in Greece
- Volunteers
- 124 people
- Sponsor
- Abbott
Systemic Sclerosis, Idiopathic Inflammatory Myopathies
A Study of AZD0120 in Autoimmune Diseases
This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with systemic sclerosis (SSc)…
- Conditions
- Systemic Sclerosis, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis
- Trial name
- AURORA (NCT07295847)
- Testing
- AZD0120
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and efficacy of various repeat-dose regimens of KB003 in subjects with active Rheumatoid Arthritis (RA) who have had an inadequate prior treatment…
- Trial name
- NCT00995449
- Testing
- KB003
- Where
- 11 sites in United States
- Volunteers
- 9 people
- Sponsor
- Humanigen, Inc.
Rheumatoid Arthritis
Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid Arthritis
This study is to assess the safety, tolerability, and pharmacokinetics (PK) of multiple infusions of GS-5745 in adults with rheumatoid arthritis (RA).
- Trial name
- NCT02176876
- Testing
- GS-5745
- Where
- 4 sites in Czechia, Hungary
- Volunteers
- 18 people
- Sponsor
- Gilead Sciences
Active Rheumatoid Arthritis
Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and efficacy of ATN-103 when administered to subjects with active rheumatoid arthritis compared with placebo. All subjects must be on a stable dose and route of methotrexate.
- Trial name
- NCT00959036
- Testing
- ATN-103, Methotrexate
- Where
- 67 sites in United States, Belgium and 7 more
- Volunteers
- 252 people
- Sponsor
- Ablynx, a Sanofi company
Rheumatoid Arthritis
A Non-Interventional Study of RoActemra/Actemra (Tocilizumab) Treatment in Patients With Rheumatoid Arthritis
This multicenter, observational study will evaluate the use and efficacy of RoActemra/Actemra (tocilizumab) in routine clinical practice in patients with moderate to severe rheumatoid arthritis.
- Trial name
- NCT01952509
- Where
- 6 sites in Costa Rica, Dominican Republic and 2 more
- Volunteers
- 169 people
- Sponsor
- Hoffmann-La Roche
Osteoarthritis, Rheumatoid Arthritis
Randomized Controlled Clinical Evaluation to Compare Vanguard Cruciate Retaining and AGC Total Condylar Knee Implants
This evaluation is being conducted on the relative new knee system, the Vanguard Cruciate Retaining (CR) to evaluate clinical efficacy of the Vanguard CR components.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- Vanguard (NCT01064063)
- Testing
- Vanguard CR, AGC knee
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Zimmer Biomet
Arthritis, Rheumatoid
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Rheumatoid Arthritis.
The purpose of this study is to evaluate the safety and effectiveness of Infliximab (Remicade) in patients with Rheumatoid Arthritis.
- Trial name
- NCT00036387
- Testing
- Infliximab
- Volunteers
- 347 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Study of PTC844 in Participants With Active Rheumatoid Arthritis
This study is designed to assess the safety, pharmacokinetics (PK), and biomarker effects of PTC844 compared to placebo in participants with active rheumatoid arthritis (RA).
- Trial name
- NCT07779616
- Testing
- PTC844
- Volunteers
- 75 people
- Sponsor
- PTC Therapeutics
Arthritis, Rheumatoid
Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome
Study to assess the safety profile of meloxicam by comparing incidence of gastrointestinal adverse events of meloxicam with that of NSAID in the routine daily therapeutic situation.
- Trial name
- NCT02180516
- Testing
- Meloxicam, Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac
- Volunteers
- 9,984 people
- Sponsor
- Boehringer Ingelheim
Arthritis, Rheumatoid
Study Of The Safety Of CE 224,545 And Methotrexate In Patients With Rheumatoid Arthritis
CE 224,535 is being developed for the treatment of rheumatoid arthritis. The purpose of this study is to evaluate the safety and tolerability of CE 224,535 after 4 weeks of treatment in subjects with rheumatoid arthritis already…
- Trial name
- NCT00446784
- Testing
- CE-224,535, Methotrexate
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
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