Clinical trials: RANDOMIZED
Healthy
Effects of Food on Oxycodone Pharmacokinetics in Healthy Volunteers
To estimate the effect of food on the pharmacokinetics and relative bioavailability of oxycodone following oral administration of single 40 mg doses of PF 00345439 Formulation K taken whole or after chewing in healthy volunteers.
- Trial name
- NCT02117583
- Testing
- Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Women With Low Sexual Satisfaction, Partners of Women With Low Sexual Satisfaction
Progressive Muscle Relaxation Exercises Women With Low Sexual Satisfaction Sexual Satisfaction and Functioning of Women and Their Partners
This study was conducted to investigate the effect of progressive muscle relaxation exercises on sexual satisfaction and functioning of women and their partners in women with low sexual satisfaction.
- Trial name
- NCT06354283
- Testing
- Progressive Muscle Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Halic University
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
A Phase 2 Study of Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Junction (GEJ) Cancer
The main purpose of this study was to evaluate the safety and pharmacokinetics of administering various dose regimens of ramucirumab in participants with advanced gastric cancer whose disease has progressed during or following…
- Trial name
- NCT02443883
- Testing
- Ramucirumab
- Where
- 45 sites in United States, Argentina and 10 more
- Volunteers
- 164 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder (MDD), Probiotic Intervention
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
The goal of this clinical trial is to evaluate the efficacy and safety of sertraline combined with Lactobacillus crispatus in adolescents aged 12-18 years with major depressive disorder.
- Trial name
- NCT07539805
- Testing
- Sertraline combined with Lactobacillus crispatus
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Postoperative Delirium (POD), Postoperative Sleep Disturbance
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher…
- Trial name
- EPISODE (NCT06900205)
- Testing
- Esketamine, 0.9 % saline
- Where
- China
- Sponsor
- RenJi Hospital
Cholangiocarcinomas
PiCCA Study (Panitumumab in Combination With Cisplatin/Gemcitabine)
The purpose of this study is to determine the efficacy of panitumumab plus cisplatin/gemcitabine (CisGem) combination chemotherapy in KRAS wild-type biliary tract cancer patients without systemic pre-treatment, compared to the…
- Trial name
- PiCCA (NCT01320254)
- Testing
- Cisplatin, Gemcitabine, Panitumumab, Cisplatin, Gemcitabine
- Where
- 16 sites in Germany
- Volunteers
- 93 people
- Sponsor
- Hannover Medical School
Idiopathic Thrombocytopenic Purpura
A Study in Healthy Subjects to Evaluate Bioavailability of 4 Formulations of E5501
This is a study in healthy subjects. There are two parts to the study. In the first part of the study each subject will receive a single 10mg dose of each of the four formulations of E550.
- Trial name
- NCT01549054
- Testing
- 10-mg dose of E5501 2G tablet, 10-mg dose of E5501 cyclodextrin oral solution, 10-mg dose of E5501-P21% powder
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
OSA - Obstructive Sleep Apnea, Obesity
A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy
The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA but not receiving PAP
- Trial name
- NCT07387094
- Testing
- XW003 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Osteoporosis, Bone Loss, Postmenopausal
DPP4-Inhibitors and Bone Metabolism in Diabetes
Background Bone frailty and fractures are common conditions in patients with type 2 diabetes (T2D) and represent a major cause of morbidity and hospitalization in this population.
- Conditions
- Osteoporosis, Bone Loss, Postmenopausal, Diabetes Mellitus Type 2
- Trial name
- SlowDOWN (NCT06770894)
- Testing
- Sitagliptin 100 mg
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Azienda Policlinico Umberto I
Parkinson's Disease
Carbidopa/Levodopa/Entacapone Versus Immediate Release (IR) Carbidopa/Levodopa on Non-motor Symptoms in Patients With Idiopathic Parkinson's Disease and Demonstrating Non-motor Symptoms of Wearing Off
The purpose of this study is to test the effects of carbidopa/levodopa/entacapone compared to the effects of immediate-release carbidopa/levodopa on non-motor symptoms of end-of-dose wearing off in persons who have Parkinson's…
- Trial name
- NCT00642356
- Testing
- Carbidopa/levodopa/entacapone, Immediate release carbidopa/levodopa
- Where
- 21 sites in United States
- Volunteers
- 14 people
- Sponsor
- Novartis
Anxiety, Dental
Virtual Reality Technology on Pain Perception and Anxiety Levels in Adolescents and Young Adults During Third Molar Germ Avulsion Surgery (VIDAMO)
For a long time, the fear of the dental surgeon has been the main reason why a percentage of the population avoids regular consultation.
- Trial name
- VIDAMO (NCT04609956)
- Testing
- Virtual reality, Standard
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Spinal Cord Injuries (SCI), Urinary Retention
Clinical Trial of Abdominal Breathing for Urinary Retention After Spinal Cord Injury
Randomized controlled trials were conducted in patients with urinary retention after spinal cord injury. The effects of abdominal breathing training on pelvic floor muscle tone, muscle strength and residual urine volume in…
- Trial name
- NCT06964256
- Testing
- Abdominal breathing exercises, Control group: intermittent catheterization, Experimental group: intermittent catheterization
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qilu Hospital of Shandong University
Diabetes Mellitus Type 2, Hypertension
Mobile Sipoo - Telemonitoring With Combined With Active Assistance Technology
Mobile Sipoo is a randomized controlled trial aiming to improve selfcare and outcomes of diabetes and hypertensive patients by introducing a remote patient monitoring system supported with automatic patient decision support.
- Trial name
- NCT01547156
- Testing
- Intervention group
- Where
- Finland
- Volunteers
- 56 people
- Sponsor
- VTT Technical Research Centre of Finland
Multiple Sclerosis, Lower Urinary Tract Symptoms
Effectiveness of TTNS in MS Patients With Lower Urinary Track Symptoms
Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system. It is characterized with demyelinated plaques affecting subcortical, brain stem, and spinal cord nerve fibers.
- Trial name
- NCT06263556
- Testing
- Pelvic floor exercises, Transcutaneous posterior tibial nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Epilepsy
Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subjects With Newly or Recently Diagnosed Partial Epilepsy
To evaluate the long term effectiveness of Levetiracetam (LEV) monotherapy on Treatment Failure Rate in subjects with newly diagnosed partial onset seizures with or without secondary generalized seizures, compared to…
- Trial name
- OPTIMAL (NCT01498822)
- Testing
- Levetiracetam, Oxcarbazepine
- Where
- 23 sites in South Korea
- Volunteers
- 353 people
- Sponsor
- Korea UCB Co., Ltd.
Myofascial Pain Syndrome
COMPARISON OF THREE TREATMENT MODALITIES IN MYOFASCIAL PAIN SYNDROME
This study aims to compare the effectiveness of dry needling, extracorporeal shock wave therapy (ESWT), and pulsed radiofrequency (PRF) in patients with chronic musculoskeletal pain.
- Trial name
- MPS-TREAT (NCT07511751)
- Testing
- Dry Needling, Extracorporeal Shock Wave Therapy, Pulsed radiofrequency(PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- ALİEMAN
Cystic Fibrosis in Children, Telerehabilitation
Virtual Reality Based Tele-Exercises on Exercise Capacity in Cystic Fibrosis
The goal of this clinical trial is to investigate the effects of a-12-week virtual reality exercise program, applied as tele-exercise, on the exercise capacity of children with cystic fibrosis, whose physical activity level is…
- Conditions
- Cystic Fibrosis in Children, Telerehabilitation, Virtual Reality
- Trial name
- NCT05850351
- Testing
- Virtual reality, Online
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Koç University
Burns
Randomized Study of Testosterone and Progressive Resistance Exercise in Men With Burn Injury
OBJECTIVES: I. Determine whether testosterone normalization ameliorates muscle protein hypercatabolism by increasing net protein synthesis in men with burn injury. II.
- Trial name
- NCT00006129
- Testing
- testosterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Center for Research Resources (NCRR)
Hepatocellular Carcinoma, Liver Carcinoma
the Effect of Nutrition-optimized Prehabilitation on Perioperative Intervention in Primary Liver Carcinoma
This study aimed to evaluate whether nutritional optimization-led triple prehabilitation could improve perioperative nutritional status, promote postoperative recovery, and reduce postoperative complications in patients with…
- Conditions
- Hepatocellular Carcinoma, Liver Carcinoma, Hepatobiliary Cancers, Primary Liver Cancer
- Trial name
- NCT06549829
- Testing
- Nutritional optimization-led triple prehabilitation Intervention, Conventional triple prehabilitation Intervention
- Where
- 3 sites in China
- Volunteers
- 132 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatitis C, HIV Infections
Peginterferon Alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients
This study will evaluate the safety and effectiveness of combination therapy with peginterferon alfa-2b and ribavirin for treating hepatitis C virus (HCV) infection in HIV-infected patients.
- Trial name
- HEPCPR (NCT00018031)
- Testing
- Peginterferon alfa-2b, Ribavirin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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