Clinical trials: RANDOMIZED
Kidney Stone
A RCT to Evaluate the Efficacy and Safety of Automated Needle Targeting (ANT-X) System Compared to Traditional Free Hand Puncture for Renal Access in Percutaneous Nephrolithotomy (PCNL)
Objectives: This study aims to determine if the device provides an advantage over traditional free hand puncture by comparing the number of attempts required to obtain access, time to achieve access, radiation exposure to patient…
- Trial name
- NCT05213702
- Testing
- Renal Calyx punture with traditional free hand or ANT-X device
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Bladder Cancer, Urothelial Carcinoma
A Phase 3 Study of UGN-102 for Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer
This global, randomized, controlled, open-label Phase 3 study was designed to assess the long-term efficacy and safety of UGN-102 (mitomycin) for intravesical solution with or without (±) transurethral resection of bladder tumors…
- Conditions
- Bladder Cancer, Urothelial Carcinoma, Urothelial Carcinoma Bladder
- Trial name
- ATLAS (NCT04688931)
- Testing
- UGN-102, TURBT
- Where
- 139 sites in United States, Bulgaria and 8 more
- Volunteers
- 282 people
- Sponsor
- UroGen Pharma Ltd.
Intraoperative Complications
Study of Different Concentrations of Epidural Bupivacaine for the Effects on Vasodilatation and Sensory Block
This study aims to compare human subjects receiving epidural bupivacaine local anesthetic at different doses and concentrations and to assess the effect on vasodilatation (sympathectomy), sensory and motor block.
- Trial name
- NCT00197353
- Testing
- Epidural bupivacaine (dose/concentration/volume ranging)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Distal Radius Fracture
Comparison of Rehabilitation Intervention, Supported by Telemedicine, With Standard Rehabilitation After Distal Radius Fracture.
This is a randomized clinical trial of two parallel arms, aiming to compare two rehabilitation interventions: an experimental intervention including telemedicine support and remote monitoring of compliance of usual indicated…
- Trial name
- NCT05463653
- Testing
- Experimental
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Hospital Clinico Mutual de Seguridad
Myelofibrosis, Primary Myelofibrosis
To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)
The purpose of the study is to compare the efficacy and safety of parsaclisib when combined with ruxolitinb versus placebo combined with ruxolitinib in participants with myelofibrosis who have suboptimal response while receiving…
- Conditions
- Myelofibrosis, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis
- Trial name
- NCT04551053
- Testing
- parsaclisib, ruxolitinib
- Where
- 177 sites in United States, Austria and 17 more
- Volunteers
- 177 people
- Sponsor
- Incyte Corporation
Bronchoscopy, General Anesthesia
Preprocedural Video Education for Bronchoscopy Anxiety
The goal of this clinical trial is to learn whether preprocedural video education can reduce anxiety in adult patients who are scheduled to undergo bronchoscopy under general anesthesia.
- Trial name
- NCT07639437
- Testing
- Verbal + Audiovisual educational video, Verbal only
- Where
- Indonesia
- Volunteers
- 58 people
- Sponsor
- RSUP Persahabatan
Mastectomy, Upper Limb Amputation Below Elbow
Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study
The ultimate objective of the proposed line of research is to determine if cryoanalgesia is an effective adjunctive treatment for pain in the period immediately following various painful surgical procedures; and, if this…
- Conditions
- Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee
- Trial name
- NCT03578237
- Testing
- Cryoneurolysis (active)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Diego
Healthy
First-in-Human Single and Multiple Dose of GLPG1837
The purpose of this First-in-Human study is to evaluate the safety and tolerability after single ascending oral doses of GLPG1837 given to healthy subjects, compared to placebo.
- Trial name
- NCT02325037
- Testing
- GLPG1837 single ascending doses, GLPG1837 multiple ascending doses
- Where
- Belgium
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Migraine Disorders
Tai Chi for the Prophylaxis of Episodic Migraine: the Efficacy Examination and Mechanism Exploration
The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism…
- Trial name
- NCT05690737
- Testing
- Tai Chi training, Standard prophylactic medication
- Where
- 2 sites in Hong Kong
- Volunteers
- 220 people
- Sponsor
- The Hong Kong Polytechnic University
Renal Recipients
Effect of Patient Education on Kidney Recipients Knowledge, Coping and Quality of Life
For patients with end-stage kidney disease, transplantation is the treatment of choice, offering improved quality of life by restored metabolism and freedom from dialysis.
- Trial name
- NCT01184937
- Testing
- Patient education program
- Where
- Norway
- Volunteers
- 159 people
- Sponsor
- Oslo Metropolitan University
Chronic Tension-Type Headache
The Efficacy of Acupuncture and Fu's Subcutaneous Needling (FSN ) in Treating Chronic Tension-type Headache by fMRI
Epidemiological studies show a one-year prevalence of 30%-60% for episodic tension-type headache (TTH) and 2%-3% for chronic TTH (CTTH).
- Trial name
- NCT03171337
- Testing
- Acupuncture, Fu's Subcutaneous Needling (FSN)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Jiang Xumei
Spinal Fusion, Cervical Spine Degenerative Disease
Early Postoperative Home Exercise Program After Cervical Spine Surgery
The overall objective of this two-group randomized controlled trial is to gather preliminary evidence on the efficacy and safety of early postoperative exercise for improving disability, pain, and general physical health in…
- Trial name
- NCT02720172
- Testing
- Early Home Exercise Program, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Post Herpetic Neuralgia
Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia
The purpose of this study is to investigate whether NXN-462, a selective nNOS inhibitor, is effective in reducing pain levels in patients with post-herpetic neuralgia.
- Trial name
- NCT01748877
- Testing
- NXN-462
- Where
- 25 sites in United States, Canada
- Volunteers
- 188 people
- Sponsor
- NeurAxon Inc.
Operative Time
Improving Planned Surgical Case Duration Accuracy by Leveraging the EHR and Predictive Modeling
The investigators are studying the duration it takes surgeons to complete their respective surgical cases. The hospital hopes to improve the overall operating room scheduling accuracy from this project.
- Trial name
- NCT03471377
- Testing
- standard scheduling process, assigned a planned case duration value from predictive model
- Where
- United States
- Volunteers
- 683 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity, PreDiabetes
Network Meta-analysis of Intermittent Fasting and Cardiometabolic Risk
Intermittent fasting is a method of restricting calories over a defined period of time and includes regimens such as whole-day fasting, alternate-day fasting, and time-restricted feeding.
- Conditions
- Obesity, PreDiabetes, Diabetes, Hypertension
- Trial name
- NCT05309057
- Testing
- Intermittent Fasting
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Anesthesia General, Ultrasonography
Comparison of Two Airway Devices (I-Gel and Air-Q) in Children Aged 1-10 Years During General Anesthesia
This study aims to compare two commonly used airway devices (I-gel and Air-Q) in children aged 1-10 years undergoing general anesthesia for surgery.
- Conditions
- Anesthesia General, Ultrasonography, Laryngeal Mask Airways, Airway Management
- Trial name
- NCT07522957
- Testing
- I-gel supraglottic airway device, Air-Q SP supraglottic airway device
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Diabetes Mellitus, Type 2
An Investigational Drug Study in Patients With Type 2 Diabetes Mellitus (MK0431-023)
The purpose of this study is to determine the safety and effectiveness of an investigational drug in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT00094757
- Testing
- Comparator: sitagliptin 100 mg, Comparator: sitagliptin 200 mg, Comparator: pioglitazone
- Volunteers
- 521 people
- Sponsor
- Merck Sharp & Dohme LLC
Polio
Effect of Digital Payment to Campaign Health Workers on Vaccination Coverage
Introduction: Good quality OPV campaigns can interrupt and possibly prevent transmission of the polio virus. Health care worker performance and motivation are prerequisites for the success of such campaigns.
- Trial name
- NCT05684081
- Testing
- Digital payment
- Where
- Uganda
- Volunteers
- 2,700 people
- Sponsor
- Makerere University
Disability Physical, Genital Infection
The Effect of Web Based Genital Hygiene Education Provided to Orthopedically Disabled Women
The aim of this study is to determine the effect of web-based genital hygiene education provided to orthopedically disabled women on self care agency and genital hygiene behaviors.
- Trial name
- NCT04723381
- Testing
- web based education
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Siirt University
Head and Neck Cancer (H&N)
Effects of Far Infrared Rays and Transcutaneous Electrical Nerve Stimulation on Short Term Prognosis of Head and Neck Cancer Patients Receiving Curative Treatment
This clinical trial aims to evaluate whether far infrared radiation therapy and transcutaneous electrical nerve stimulation can reduce treatment-related side effects in patients with head and neck cancer undergoing concurrent…
- Trial name
- NCT07689019
- Testing
- Standard Care (in control arm), Transcutaneous Electrical Nerve Stimulation, Far-Infrared Therapy
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- Buddhist Tzu Chi General Hospital
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