Clinical trials: RANDOMIZED
Pneumonia, Hypoxemia
Solar Oxygen Study
Globally, approximately 7.7 million children per year die before the age of 5 years. Infectious diseases account for a large proportion of these deaths, with pneumonia being the leading cause of mortality (2.1 million…
- Trial name
- SOS (NCT03851783)
- Testing
- Solar-powered oxygen
- Where
- 20 sites in Uganda
- Volunteers
- 2,405 people
- Sponsor
- University of Alberta
Pulmonary Emphysema in Alpha-1 PI Deficiency
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)
This is a multi-center, randomized, placebo-controlled, double blind clinical study to assess the efficacy and safety of two separate dose regimens of Alpha-1 MP versus placebo for 156 weeks (i.e., 3 years) using computed…
- Trial name
- SPARTA (NCT01983241)
- Testing
- Alpha-1 MP, 0.9% Sodium Chloride for Injection, USP
- Where
- 52 sites in United States, Argentina and 15 more
- Volunteers
- 345 people
- Sponsor
- Grifols Therapeutics LLC
Migraine
Two Rizatriptan Prescribing Portions for Treatment of Migraine
The primary objective of this study is to evaluate a clinical limit (CL) of rizatriptan (9 rizatriptan 10mg Orally Disintegrating Tablet (ODT) per month) versus (vs.) a formulary limit (FL) of rizatriptan (27 rizatriptan 10mg ODT…
- Trial name
- NCT00397254
- Testing
- rizatriptan
- Where
- 10 sites in United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Clinvest
Iron-deficiency, Transplant-Related Disorder
Effect of Ferric Carboxymaltose on Exercise Capacity After Kidney Transplantation
Iron deficiency is common in kidney transplant recipients and is associated with impaired exercise tolerance and an unfavourable prognosis.
- Trial name
- EFFECT-KTx (NCT03769441)
- Testing
- Ferric carboxymaltose, Sodium chloride
- Where
- 2 sites in Netherlands
- Volunteers
- 148 people
- Sponsor
- University Medical Center Groningen
Stroke
Comparison of Training in Virtual Environment With and Without Physiotherapeutic Intervention in Chronic Stroke Patients
The aim of this study is to compare the effects of balance training in a virtual environment with and without physiotherapeutic intervention on the motor function, balance and gait in chronic stroke patients.
- Trial name
- NCT03361241
- Testing
- No Physiotherapeutic Intervention, Physiotherapeutic Intervention
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Carpal Tunnel Syndrome
The Effect of Low-Level Laser Therapy in Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is a chronic compression of the median nerve, which can lead to symptoms such as nocturnal pain and paresthesia in the area innervated by the median nerve.
- Trial name
- KaLi-CTS (NCT06248541)
- Testing
- treatment with low-level laser therapy, treatment with conventional light diodes
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Atrial Fibrillation
Hong Kong Outpatient AF Screening Using Single-lead ECG Device
Stroke is a leading cause of mortality, morbidity and rising healthcare cost worldwide. In 'real-world' practice, AF is often diagnosed too late at time of stroke and detection can be difficult because AF may be present without…
- Trial name
- NCT02409654
- Testing
- Patient education, Routine care
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Opioid-use Disorder
Pharmacokinetic and Safety Study of Naltrexone Release From Subcutaneous BICX104 Pellets Compared to Vivitrol Injections
This is a Phase 1, 6-month, open-label, multi-center study in parallel groups of randomized healthy volunteers to evaluate the pharmacokinetics and safety of BICX104 implantable subcutaneous naltrexone pellets and Vivitrol…
- Trial name
- NCT04828694
- Testing
- BICX104, Vivitrol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- BioCorRx Inc
Parkinson's Disease
Segmental Laser Acupuncture for Constipation and Sleep in Patients With Parkinson's Disease
Parkinson's disease (PD) is characterized not only by motor symptoms but also by common and clinically significant non-motor symptoms, including constipation and sleep disturbances, which can substantially impair quality of life.
- Trial name
- NCT07790094
- Testing
- TI-816-3E3 Portable Laser Phototherapy Device
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
Healthy Participants
Randomized Controlled Trial of ADAPT
This trial examines the effectiveness of a novel neurodevelopmentally informed intervention - Adolescent Developmentally-Appropriate health Promotion Therapy (ADAPT) - on preventing alcohol use and promoting well-being among…
- Trial name
- NCT07132866
- Testing
- ADAPT
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- University of Aarhus
Sedentary Adults
Effects of Flexi-Bar Training in Different Postures on Core Muscle Activation, Trunk Muscle Strength, and Balance in Sedentary Adults
Trunk stability is a fundamental basis for achieving proximal stability and facilitating distal mobility, and is closely associated with balance control and neuromuscular coordination.
- Trial name
- NCT07872566
- Testing
- Flexi-Bar training with sitting posture, Flexi-Bar training with standing posture
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fooyin University
Periodontitis
Regeneration of Human Intrabony Defects With rhFGF-2/HA
BACKGROUND: Periodontal disease is an infection that results in progressive loss of dental support, which may lead to tooth loss..
- Trial name
- NCT02337166
- Testing
- a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Myelofibrosis
A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment
The purpose of the study is to evaluate the overall survival of participants treated with imetelstat compared to best available therapy with intermediate-2 or high-risk Myelofibrosis (MF) who are relapsed/refractory (R/R) to…
- Trial name
- NCT04576156
- Testing
- Imetelstat, Best Available Therapy (BAT)
- Where
- 144 sites in United States, Argentina and 24 more
- Volunteers
- 327 people
- Sponsor
- Geron Corporation
Plasma Exchange
A Randomized Trial Examining Plasma Exchange Using the Becton Dickinson (BD) Catheter In an Outpatient Apheresis Unit
This is a randomized pilot study of therapeutic apheresis procedures (TAP) using the current standard of care catheter (SOC) vs the BD Nexiva Diffusics Catheter. It is a single blinded, randomized study.
- Trial name
- REPLACE (NCT04253756)
- Testing
- 20-gauge BD Nexiva Diffusics
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy Subjects
Safety and Efficacy of Trans Sodium Crocetinate (TSC) in Enhancing Tissue Oxygen Levels in Healthy Volunteers
Randomized, double-blind, placebo-controlled, pharmacokinetic, pharmacodynamic study. Subjects will be randomized to TSC or placebo to determine the effect of Trans Sodium Crocetinate (TSC) on Transcutaneous Oximetry Measurements…
- Trial name
- NCT04808622
- Testing
- Trans-Sodium Crocetinate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Diffusion Pharmaceuticals Inc
Coronary Artery Disease (non-left Main), Coronary Bifurcation Lesion
The European Bifurcation Club Randomized Trial of Stepwise Provisional Stenting Versus Drug Coated Balloon Therapy for Non-left Main True Coronary Bifurcations
Clinical outcomes are worse in patients with coronary artery bifurcation lesions, even if commonly encountered in clinical practice.
- Trial name
- EBC DCB (NCT06822322)
- Testing
- Percutaneous Coronary Angioplasty, Stepwise Provisional Stent Strategy, Drug Coated Balloon Strategy
- Volunteers
- 750 people
- Sponsor
- Ceric Sàrl
Ventricular Arrhythmias
A PRospective, rAndomizEd Comparison of subcuTaneOous and tRansvenous ImplANtable Cardioverter Defibrillator Therapy
This randomized controlled trial will outline the advantages and disadvantages of the subcutaneous implantable cardioverter defibrillator (ICD) compared to the transvenous ICD.
- Trial name
- PRAETORIAN (NCT01296022)
- Testing
- Implantation of subcutaneous ICD, Implantation of transvenous ICD
- Where
- 39 sites in United States, Czechia and 4 more
- Volunteers
- 850 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
High Risk Pregnant Women, Placental Insufficiency
Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
This is a Multicenter, randomized, open-label, parallel groups study to test the hypothesis that prophylactic low molecular weight heparin (LMWH) (enoxaparin) initiated before 14 weeks of gestation could improve maternal and…
- Conditions
- High Risk Pregnant Women, Placental Insufficiency, Preeclampsia
- Trial name
- HOPPE (NCT01388322)
- Testing
- Enoxaparin
- Where
- 4 sites in Spain
- Volunteers
- 361 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Maternal Health, Infant Health
Using Advanced Data Systems to Improve Health in Early Life in Rural Nepal
The goal of this cluster randomized controlled trial is to study the effect of a mobile-phone based application used by pregnant women on maternal and newborn health indicators.
- Conditions
- Maternal Health, Infant Health, Institutional Delivery, Birth Preparedness and Complication Readiness
- Trial name
- CITH (NCT05697822)
- Testing
- Mobile Phone and Cloud-based Electronic Contact and Recording System
- Where
- Nepal
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Amit Arjyal
Primary Dysmenorrhea (PD)
Pelvic Nerve Mobilization for Primary Dysmenorrhea
Primary dysmenorrhea is a highly prevalent condition among young women and is associated with significant pain, reduced quality of life, and academic absenteeism.
- Trial name
- PNM-PD (NCT07354451)
- Testing
- External Pelvic Nerve Mobilization
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Hail
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