Clinical trials: RANDOMIZED
Brain Disorder, Home Based Rehabilitation
Effect of Untact Upper Extremity Rehabilitation Using Smart Glove for Late Subacute and Chronic Patients With Brain Disorder
The aim is to clinically validate the clinical efficacy, usability, and safety of home-based upper limb rehabilitation training using the Neofect Smart Glove by comparing the effects between a group using the home-based Neofect…
- Trial name
- brain disorder (NCT06837324)
- Testing
- home-based Neofect Smart Glove, home-based occupational therapy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Cervical Intraepithelial Neoplasia
Topical Imiquimod vs. LEEP for Women With Carcinoma In-situ of the Cervix
OBJECTIVE: The standard of care for high grade cervical intraepithelial neoplasia grade 2 to 3 (CIN 2-3) has been the excision of the cervical transformation zone by way of a loop electrosurgical excision procedure (LEEP) or cold…
- Trial name
- NCT02130323
- Testing
- Imiquimod, Loop Electrosurgical Excision Procedure
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Lidocaine Infusion, Neuraxial Opioid
Effect of Lidocaine Infusion on Neuraxial Opioid-induced Pruritus After Cesarean Section
The aim of this study is to assess the efficacy and potency of lidocaine infusion as a preventive measure on pruritus response after injection of 200 micro gram morphine with bupivacaine subarachnoid block, spinal anesthesia, in…
- Conditions
- Lidocaine Infusion, Neuraxial Opioid, Pruritus, Cesarean Section
- Trial name
- NCT06225323
- Testing
- Lidocaine, Saline
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Aswan University
Depressive Disorder, Major
Does Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?
Repeated Transcranial Magnetic Stimulation - R.TMS - is currently part of the treatment for depressive illness. This non-invasive technique is designed to stimulate certain areas of the cerebral cortex involved in this pathology.
- Trial name
- DESTIMCARE (NCT03436823)
- Testing
- nurse semi-structured interview, Music & Relaxation with eyes closed
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Chronic Spontaneous Uriticaria
Study of Efficacy and Safety of Omalizumab in Refractory Chronic Spontaneous Urticaria Patients
This was a Phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of omalizumab administered subcutaneously as an add-on therapy for the treatment of…
- Trial name
- NCT02329223
- Testing
- Omalizumab
- Where
- 39 sites in Japan, South Korea
- Volunteers
- 218 people
- Sponsor
- Novartis Pharmaceuticals
Stone, Kidney
Endoscopic Combined Intrarenal Surgery Versus Multi-Tract Percutaneous Nephrolithotomy for Complex Renal Stones:
The aim of this study is to compare outcomes of endoscopic combined intrarenal surgery (ECIRS) with the multi-tract percutaneous nephrolithotomy for management of complex renal stones.
- Trial name
- NCT05460559
- Testing
- Group A (p-PCNL) procedure, Group B (s-ECIRS) procedure
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mansoura University
Covid19
Safety and Preliminary Efficacy of the Combination of Niclosamide and Camostat
Niclosamide (2000 mg QD) and Camostate (600 mg QID) are expected to be safe and well-tolerated as a combination therapy and to show clinically beneficial for COVID-19 patients.
- Trial name
- NICCAM (NCT04750759)
- Testing
- Niclosamide + Camostat
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Charité Research Organisation GmbH
Chronic Kidney Disease
The Effect of Citrasate Dialysate on Heparin Dose in Hemodialysis
An alternative to systemic heparin anticoagulation for HD is citrate dialysate (CD). CD contains a small amount of citric acid rather than acetic acid as the acidifying agent.
- Trial name
- NCT01466959
- Testing
- citrate dialysate (CD), acetic-acid based dialysate (AD)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Hyponatremia With Normal Extracellular Fluid Volume
Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia
The present study is designed to confirm and extend the observation from previous studies that lixivaptan therapy corrects hyponatremia, in euvolemic subject, including subjects with SIADH.
- Trial name
- NCT00660959
- Testing
- lixivaptan
- Where
- 71 sites in United States, Belgium and 4 more
- Volunteers
- 106 people
- Sponsor
- CardioKine Inc.
Methicillin-resistant Staphylococcus Aureus
Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)
The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant…
- Trial name
- REDUCE-MRSA (NCT00980980)
- Testing
- Chlorhexidine bath and nasal mupirocin
- Where
- 42 sites in United States
- Volunteers
- 74,256 people
- Sponsor
- Harvard Pilgrim Health Care
Chronic Low Back Pain
The Effect of ESWT Added to Conservative Treatment on Pain, Disability, and Ultrasonographic Outcomes in Chronic Low Back Pain
Chronic low back pain (CLBP) is a major public health concern worldwide, leading to reduced quality of life and significant work loss.
- Trial name
- ESWT (NCT07132762)
- Testing
- Radial Extracorporeal Shock Wave Therapy, Conventional rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Pamukkale University
Schizophrenia
Study of SPG302 in Adults With Schizophrenia
This Phase 2 study described herein will evaluate the safety, efficacy, tolerability, and pharmacodynamics of SPG302 in adults with a primary diagnosis of schizophrenia.
- Trial name
- NCT06442462
- Testing
- SPG302
- Where
- 3 sites in United States, Australia
- Volunteers
- 32 people
- Sponsor
- Spinogenix
Regional Anesthesia Morbidity, Hip Surgeries
Pericapsular Nerve Group Block vs. Fascia Iliaca Compartment Block vs. Caudal Block for Hip Surgeries
The study aims to compare the effect of pericapsular nerve group block versus fascia iliaca compartment block versus caudal block regarding Postoperative analgesia in children undergoing hip surgeries.
- Conditions
- Regional Anesthesia Morbidity, Hip Surgeries, Perioperative Analgesia
- Trial name
- NCT07137962
- Testing
- PENG Block, FICB Block, Caudal Block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Meningococcal Disease
Effectiveness, Immunogenicity and Safety of Meningococcal ABCWY Vaccine Administered to Healthy Adolescents
Evaluate the effectiveness of 2 doses of MenABCWY vaccine in adolescents compared to a single dose of MenACWY vaccine.
- Trial name
- NCT02140762
- Testing
- MenABCWY, MenACWY
- Where
- 8 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Edentulous Alveolar Ridge In Mandible, Complete Edentulism
Compare the Difference in Occlusal Force Distribution and Denture Retention Using 2 Different Denture Base Materials in Implant Retained Overdenture
The global increase in the aging population has led to a rise in total edentulism, which remains a major public health concern. two-implant-retained mandibular overdentures have been regarded as the standard of care, offering…
- Conditions
- Edentulous Alveolar Ridge In Mandible, Complete Edentulism, Dental Implant, Attachments
- Trial name
- NCT07250503
- Testing
- Conventional acrylic resin denture, Flexible resin denture
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Varicose Veins, Vascular Diseases
New Compression Hosiery Versus Standard Class II Compression Stockings After Endothermal Ablation
A prospective comparative randomized multicentre non-inferiority trial. The purpose of this study is to compares of a short compression hosiery (stocking without a foot, compression class 2) with standard compression class 2…
- Trial name
- COSMOS (NCT03477227)
- Testing
- Short stocking, Usual stocking
- Where
- 3 sites in Russia
- Volunteers
- 187 people
- Sponsor
- Pirogov Russian National Research Medical University
HIV-1-infection
Study of an Injectable Regimen of GS-3242 With Lenacapavir Compared to Biktarvy in People New to HIV-1 Treatment
The study will have two portions: Phase 2 and Phase 3. Phase 2 will further have 2 parts: Part A and Part B. The goal of Phase 2, Part A is to assess the effectiveness of study drugs GS-3242 plus Lenacapavir (LEN) versus Biktarvy…
- Trial name
- NCT07708727
- Testing
- GS-3242 Tablet, GS-3242 Injection, Lenacapavir Tablet
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 700 people
- Sponsor
- Gilead Sciences
Ehlers-Danlos Syndrome, Vascular Type
Angiotensin II Receptor Blockade in Vascular Ehlers Danlos Syndrome (ARCADE)
This study aims to verify the hypothesis that patients with Vascular Ehlers Danlos syndrome (vEDS) should benefit of the blockade of angiotensin (Ang) II noxious effects on their vasculature affected by a defect in type III…
- Trial name
- ARCADE (NCT02597361)
- Testing
- Irbesartan
- Where
- 15 sites in France
- Volunteers
- 61 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy
Integrated Management of Pronation Deformity in Cerebral Palsy
Pronation deformity is a very common problem in children with cerebral palsy. This deformity is usually has neural and non-neural aspects.
- Trial name
- NCT03472261
- Testing
- Botulinum toxin type A, Upper extremity orthoses, Home exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Kocaeli University
Whooping Cough
A Phase I Clinical Study of a GamLPV, a Live Intranasal Bordetella Pertussis Vaccine
The study contains three periods: screening, inpatient hospitalization and follow-up. And should be leaded as a randomized placebo-controlled study with in chain order enrolled volunteers and dose escalating.
- Trial name
- NCT03137927
- Testing
- Vaccine GamLPV
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
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