Clinical trials: RCT
Hepatitis B Virus Infection; Pregnant Women
TAF vs TDF During the Pregancy
The goal of this clinical trial is to learn the efficacy and safety of Tenofovir alafenamide (TAF) vs Tenofovir disoproxil fumarate(TDF) in early and middle pregnancy antiviral therapy for chronic hepatitis B pregnant women.
- Trial name
- TAF；TDF；RCT (NCT07542951)
- Testing
- TAF
- Where
- China
- Volunteers
- 210 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Congenital Heart Disease
Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT
This is a Phase III randomized controlled trial of a passive ROM exercise program that will be performed in infants with HLHS and other single right ventricle anomalies following the Norwood procedure at PHN and Auxiliary Centers.
- Trial name
- T4G RCT (NCT04702373)
- Testing
- passive range of motion exercise therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 144 people
- Sponsor
- Carelon Research
HIV Infections
Effectiveness of Coping Training for People With HIV Experiencing Treatment Side Effects (The Balance Project)
This study will evaluate the effectiveness of cognitive behavioral coping training in improving side effect management and treatment adherence in HIV-infected patients who are taking antiretroviral medications.
- Trial name
- NCT00643903
- Testing
- Cognitive behavioral coping effectiveness training, Standard care, Single group workshop on coping effectiveness training
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Francisco
Filarial; Infestation
Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection
Diethylcarbamazine (DEC) essentially a micro-filaricidal drug is given for 12 days as standard treatment for the clearance of W. bancrofti infection.
- Trial name
- NCT02005653
- Testing
- Diethylcarbamazine, Albendazole, Doxycycline
- Where
- India
- Volunteers
- 146 people
- Sponsor
- Indian Council of Medical Research
Optic Pathway Glioma
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)
Infantile optic pathway glioma (OPG) is generally benign and slow-growing, but due to infiltration and compression of sensitive neuronal structures in the optical pathways, progressive visual loss is a frequent and highly…
- Trial name
- NGF-OPG (NCT05733572)
- Testing
- CHF6467
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Benedetto Falsini
Healthy
BMS Reverse Cholesterol Transport (RCT) Study
The purpose of this study is to investigate the use of radiolabeled particulate cholesterol administered intravenously in association with albumin, as a method to study reverse cholesterol transport (RCT) in humans by analyzing…
- Trial name
- NCT01031862
- Testing
- 3H-Cholesterol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Breast Cancer Female
Feasibility Study of ABC for Women Treated for Breast Cancer
The investigators aim to assess the feasibility and acceptability of conducting a randomised controlled trial (RCT) to test whether receiving ABC (an online-delivered, Cognitive Behavioural Therapy [CBT], group-based, body image…
- Trial name
- NCT06412341
- Testing
- Accepting your Body after Cancer, Macmillan body image booklet
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of the West of England
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of chemotherapy (CT), often requiring dose reductions or treatment interruptions, which can compromise efficacy of the planned CT…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQTmicrob (NCT06799351)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
End Stage Cancer
An Interactive Advance Care Planning Intervention to Facilitate a Good Death for Cancer Patients
The purpose of this 5-year interventional study is to design, implement, and evaluate the effectiveness of an intervention aimed at facilitating prognosis communication and end-of-life care decision-making to increase the extent…
- Trial name
- NCT01912846
- Testing
- Interactive advance care planning, Attention usual care
- Where
- Taiwan
- Volunteers
- 466 people
- Sponsor
- Chang Gung University
Postpartum Hemorrhage, Pregnancy
RCT of Misoprostol for Postpartum Hemorrhage in India
Death rates for pregnant women in rural India are approximately forty-five times higher than in the United States. Bleeding after the birth of a child and underlying anemia are the primary causes of mothers' deaths and sickness…
- Trial name
- NCT00097123
- Testing
- Misoprostol
- Where
- India
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Slow Breathing
Assessing the Acute Effects of Virtual Reality Interventions on Stress
A Four-Arm RCT, testing the acute effects of a Virtual Reality (VR)- based slow-paced breathing intervention on subjective and physiological markers of stress.
- Trial name
- VR_Stress_25 (NCT07191288)
- Testing
- VR (VR-Breathing+Mystical), VR (VR-Mystical), Computer (Non-VR-Breathing)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Surgical Site Infection
SSI Rates in Patients Undergoing Mastectomy Without Reconstruction- A Multicenter, Double-blinded RCT.
Breast cancer is the second most prevalent malignancy in the world and an important component of treatment warrants surgical procedures such as mastectomy.
- Trial name
- NCT04577846
- Testing
- Cephalexin 500 MG
- Where
- 3 sites in Pakistan
- Volunteers
- 384 people
- Sponsor
- Aga Khan University
Wound
Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention
The goal of the study is to evaluate the effectiveness of the light-emitting diode (LED) in promoting healing of the wound on lower leg as a result of surgery.
- Trial name
- NCT02383056
- Testing
- Omnilux
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Miami
Recurrent Respiratory Tract Infections
Evaluation of the Clinical Efficacy of Antrrix Probiotics in Improving Recurrent Respiratory Infections in Infants and Young Children
This study is an 8-weeks, randomized controlled trial involving children under 6 years of age who meet clinical diagnostic criteria for RRTI. Participants are randomized to receive either probiotic or placebo.
- Trial name
- NCT07297966
- Testing
- Probiotic
- Where
- 2 sites in China, Malaysia
- Volunteers
- 120 people
- Sponsor
- Min-Tze LIONG
Rib Fracture Multiple
Multicenter RCT of SSRF in Non Flail Patients
This study evaluates the efficacy of surgical stabilization of rib fractures, as compared to best medical management, for patients with multiple, displaced rib fractures.
- Trial name
- CWISNONFLAIL (NCT03221595)
- Testing
- Operative
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Denver Health and Hospital Authority
Mental Health
Self-help Books for Student Mental Health
The goal of this study is to compare the efficacy and mechanisms of change of two self-help books for college student mental health in a randomized controlled trial.
- Trial name
- NCT03779412
- Testing
- The Happiness Trap, A Mindfulness-Based Stress Reduction Workbook
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Utah State University
Esophageal Motility Disorders
U-POEM vs CO2-POEM
Multicenter randomized trial comparing post-procedural pain intensity after Per-Oral endoscopic myotomy (POEM) between two types of standard of care insufflation methods (CO2 vs Underwater).
- Trial name
- U-POEM (NCT06918730)
- Testing
- U-POEM, CO2-POEM
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- AdventHealth
Fear of Cancer Recurrence
Fear-focused Self-Compassion Therapy for Young Breast Cancer Patients' Fear of Cancer Recurrence
Few studies have tailored psychological intervention for fear of cancer recurrence (FCR) in young breast cancer patients, and the long-term efficacy of psychological intervention and its underlying mechanism are still unknown.
- Trial name
- NCT04965428
- Testing
- Fear-focused Self-Compassion Therapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shaanxi Normal University
Venous Ulcer
Community RCT of the Effectiveness of Two Compression Bandaging Technologies
Leg ulcers are emotionally distressing and painful, and often require months or years to heal. Although rarely acknowledged as a pressing health care issue, leg ulcers comprise a common, complex, and costly condition, managed…
- Trial name
- NCT00202267
- Testing
- Four-layer Bandage (Elastomeric), Short-stretch Bandage (Non-elastomeric)
- Where
- 15 sites in Canada
- Volunteers
- 426 people
- Sponsor
- Queen's University
Depression, Adolescent - Emotional Problem
RCT of a Brief Video Intervention Targeting Peer Inclusion to Reduce Depression-related Stigma in Adolescents
The goal of this study is to test the efficacy of a brief video intervention emphasizing peer inclusion on depression-related stigma and stigma outcomes (e.g., help seeking attitudes, secrecy) among adolescents 14-18.
- Conditions
- Depression, Adolescent - Emotional Problem, Stigma, Social, Help-Seeking Behavior
- Trial name
- NCT06360107
- Testing
- brief video
- Where
- United States
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute