Clinical trials: RDS
Respiratory Distress Syndrome, Adult
STUDY OF ELECTRICAL STIMULATION IN PULMONARY FUNCTION IN INTENSIVE CARE UNIT
Introduction: The Mechanical Ventilation (MV), a support method used in Intensive Care Units (ICU), reaches approximately 90% of critical patients whose withdrawal process represents 40% of the total time of their use.
- Trial name
- NCT03712215
- Testing
- Rehabilitation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Metodista de Piracicaba
Adult Respiratory Distress Syndrome, Pneumonia
Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome
The acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure with a mortality rate of approximately 40%.
- Conditions
- Adult Respiratory Distress Syndrome, Pneumonia, Sepsis
- Trial name
- NCT04079426
- Testing
- Sampling of Blood and bronchoalveolar lavage
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Bonn
Covid19, Acute Respiratory Failure
Survival Rates and Longterm Outcomes After COVID-19
The study 'Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs' is a national observational study, including patients admitted to a Norwegian ICU between March 2020 and March 2021.
- Conditions
- Covid19, Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Post Intensive Care Unit Syndrome
- Trial name
- NCT04601090
- Testing
- ICU treatment
- Where
- Norway
- Volunteers
- 860 people
- Sponsor
- Oslo University Hospital
RDS, Infant, Newborn
Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome
To research the effect of vitamin A to newborn respiratory distress syndrome by intratracheal administration with surfactant.
- Conditions
- RDS, Infant, Newborn, Vitamin A, Surfactant
- Trial name
- RDS (NCT01265589)
- Testing
- surfactant, surfactant+vitamin A
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Military Medical University
Respiratory Failure, Acute Lung Injury (ALI)
Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation
APRV mode of ventilation will result in an improved partial pressure of arterial oxygenation/ fraction of inspired oxygen (P/F ratio) on day 3 of mechanical ventilation.
- Conditions
- Respiratory Failure, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT01339533
- Testing
- Mechanical Ventilation
- Where
- 2 sites in United States
- Volunteers
- 246 people
- Sponsor
- Intermountain Health Care, Inc.
Neonatal Respiratory Distress
Transference of Established Simulated Skills (TEST) Trial
This study aims to determine if skills learned in the simulation lab, specifically in managing mask leak during positive pressure ventilation (PPV), translate effectively to the delivery room.
- Trial name
- TEST (NCT06572033)
- Testing
- Simulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Respiratory Distress Syndrome, Newborn
Observational Study on the Prophylactic Use of Curosurf in Neonatal Respiratory Distress Syndrome (RDS)
The aim of Alizé is to describe a population of premature babies (gestational age (GA) < 32 weeks) in real life situation and the management of RDS.
- Trial name
- NCT01102543
- Where
- France
- Volunteers
- 972 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Respiratory Distress Syndrome
Sustained Lung Inflation in the Delivery Room in Preterm Infants at High Risk of Respiratory Distress Syndrome
BACKGROUND. Sustained lung inflation (SLI) associated to an adequate PEEP may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (RDS) and reduce need of mechanical…
- Trial name
- SLIS (NCT01440868)
- Testing
- Sustained lung inflation
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- University of Florence
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Acute Respiratory Distress Syndrome, Cardiac Failure
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure
- Trial name
- IGNITE (NCT04669444)
- Testing
- Ventilator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Pulmonary Alveolar Proteinosis, COPD
Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection
COVID-19 Viral Global Pandemic resulting in post-infection pulmonary damage, including Fibrotic Lung Disease due to inflammatory and reactive protein secretions damaging pulmonary alveolar structure and functionality.
- Conditions
- Pulmonary Alveolar Proteinosis, COPD, Idiopathic Pulmonary Fibrosis, Viral Pneumonia
- Trial name
- GARM-COVID19 (NCT04326036)
- Testing
- Microcannula Harvest Adipose Derived tissue stromal vascular fraction (tSVF), Centricyte 1000, IV Deployment Of cSVF In Sterile Normal Saline IV Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Black Tie Medical, Inc.
Corona Virus Infection, Acute Respiratory Distress Syndrome
Losartan for Patients With COVID-19 Requiring Hospitalization
This is a multi-center, double-blinded study of COVID-19 infected patients requiring inpatient hospital admission randomized 1:1 to daily Losartan or placebo for 7 days or hospital discharge.
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection
- Trial name
- NCT04312009
- Testing
- Losartan
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Minnesota
Preterm Infant, Respiratory Distress Syndrome
Optimal Settings of Non Invasive Respiratory Support in Preterm Newborns
Noninvasive respiratory supports (NRS), such as continuous positive airway pressure (CPAP), noninvasive ventilation, high flow nasal cannula (HFNC) or nasal oxygen (O2), are commonly used in preterm newborns hospitalized in…
- Trial name
- NCT03592134
- Testing
- esophageal pressure measurement
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hôpital Necker-Enfants Malades
Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and…
- Trial name
- IP steroid (NCT01423864)
- Testing
- conventional ECMO with intravenous steroid, solumedrol
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Neonatal Respiratory Distress
Aerosolized Infasurf Treatment Protocol: Aerosolized Infasurf for Spontaneously Breathing Patients With Early RDS (AERO-03)
Surfactant replacement therapy can be life-saving for newborn infants born with symptomatic lung surfactant deficiency causing Respiratory Distress Syndrome (RDS).
- Trial name
- NCT03582930
- Testing
- Infasurf Aero
- Where
- 5 sites in United States
- Sponsor
- ONY
Acute Respiratory Distress Syndrome
Ultrasonic Weaning Criteria in Prolonged Ventilation
compare and evaluate the effect of use of ultrasonic criteria of weaning versus the conventional ways of weaning in post-traumatic acute respiratory distress syndrome (ARDS) patients who were ventilated for a long time.
- Trial name
- NCT05794867
- Testing
- clinical weaning criteria
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King Abdul Aziz Specialist Hospital
ARDS, COVID-19
Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS)
To evaluate the safety, toxicity and immunological effects of infusion of allogeneic bone marrow-derived human mesenchymal stem (stromal) cells (MSCs) and whether this therapy has an influence on the resolution processes in ARDS…
- Trial name
- NCT04377334
- Testing
- MSC
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome
Impact of Inflammation Biomarkers on the Acute Respiratory Distress Syndrome (ARDS) Definition
The ARDS has a clinical definition with criteria of the American-European Consensus Conference (1994). This definition inconveniently applies to a lot of patients with acute respiratory failure.
- Trial name
- NCT01161901
- Testing
- blood sample
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Clermont-Ferrand
Neuromuscular Blockade, Acute Respiratory Distress Syndrome
Provider Perceptions of Neuromuscular Blockade in ARDS
The proposed study will use qualitative methodology to understand health care provider perceptions of neuromuscular blockade (NMB) in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT03179709
- Testing
- Interview
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Pittsburgh
COVID-19, ARDS, Human
Cardiac Dysfunction in Critically Ill Covid-19 Patients
We conducted an observation sub-study of the prospective randomized controlled trial "High Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure", in which we analysed the echocardiographic data collected both at…
- Conditions
- COVID-19, ARDS, Human, Cardiac Failure, Right Ventricular Dysfunction
- Trial name
- NCT06197256
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Region Stockholm
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