Clinical trials: RDS
Neonatal Respiratory Distress Syndrome, Inflammatory Response
Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS
An Exploratory Randomized double-arm controlled trial to evaluate the immunomodulatory effect of low versus high dose of Alveofact with or without Budesonide.
- Conditions
- Neonatal Respiratory Distress Syndrome, Inflammatory Response, Premature Lungs, Neutrophil Extracellular Trap Formation
- Trial name
- NCT06367881
- Testing
- Alveofact, Budesonide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Acute Respiratory Distress Syndrome
Plasma Biomarkers of Cardiopulmonary Bypass Induced Acute Respiratory Distress Syndrome (CPB-ARDS)
The investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (CPB) in cardiac surgery from April 2021 to September 2022, in Wuhan.
- Trial name
- PBOARDS (NCT04696172)
- Where
- 2 sites in China
- Volunteers
- 525 people
- Sponsor
- Huazhong University of Science and Technology
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI)
Trial of Steroids in Pediatric Acute Lung Injury/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating disorders associated with lung inflammation, low oxygen levels and respiratory failure in children.
- Trial name
- SPALIT (NCT01274260)
- Testing
- methylprednisolone, Normal Saline (0.9%)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee
ARDS, AHRF
HemodynamIc eFfects of Lung Collapse and overdIstension During ARDS
The management ARDS relies on ventilatory strategies aimed at limiting ventilator-induced lung injury (VILI). The setting of PEEP is still subject of debate, as randomized clinical trials comparing standardized higher versus…
- Trial name
- HI-FIVE (NCT07423520)
- Testing
- Change in PEEP
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Covid19, Lung Injury
Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19
COVID-19 is impacting on health systems in Brazil and worldwide. Reducing the risk of clinical deterioration and prolonged disease duration in hospitalized patients with COVID-19 may alleviate the burden caused by the pandemic.
- Trial name
- NCT04470297
- Testing
- Ramelteon 8mg
- Volunteers
- 100 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Acute Respiratory Distress Syndrome
Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome accounts for 23% of mechanically ventilated patients and is associated with high mortality rate.
- Trial name
- AVALANCHE (NCT05224323)
- Testing
- Airway pressure, flow, esophageal pressure, ventilation distribution
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Distress Syndrome
Changes of Transforming Growth Factor b1 and Procollagen III in Patients With Acute Respiratory Distress Syndrome
Transforming Growth Factor-b1 (TGF-b1) is involved in the development of acute lung injury and in the fibroproliferation during acute respiratory distress syndrome (ARDS).
- Trial name
- NCT00440882
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Possible Effect Of Amniotic Fluid pH On Neonatal Morbidities In Maternal Inflammation/Infection Associated Pregnancies
Amniotic fluid (AF) pH can be affected by the maternal and/or fetal conditions such as PPROM, prematurity or fetal distress. It is known that fetal urine is the major content of AF since 20th gestational week.
- Conditions
- Respiratory Distress Syndrome, Transient Tachypnea of Newborn, Intrauterine Growth Retardation
- Trial name
- NCT02691559
- Testing
- Amniotic fluid analysis by blood gas device
- Where
- Turkey (Türkiye)
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Respiratory Distress Syndrome, Preterm Infant
Nasal High Frequency Oscillation Ventilation(NHFOV) for Respiratory Distress Syndrome
In very preterm infants with severe respiratory distress syndrome(RDS), invasive ventilation(IV) , besides nasal continuous positive airway pressure (NCPAP) and early/selective pulmonary surfactant administration, is one key…
- Trial name
- NHFOV (NCT03140891)
- Testing
- NHFOV, NCPAP
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COVID-19, Mechanical Ventilation
Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome
This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in patients…
- Conditions
- COVID-19, Mechanical Ventilation, Quality of Life, Radiologic Increased Density of Lung
- Trial name
- NCT04411459
- Testing
- Invasive mechanical ventilation
- Where
- 20 sites in Italy
- Volunteers
- 470 people
- Sponsor
- Azienda Usl di Bologna
Acute Respiratory Distress Syndrome, Covid19
Prevention and Treatment With Hydroxychloroquine + Azithromycin of Acute Respiratory Syndrome Induced by COVID-19
Multi-centered, randomized, open label clinical trial to study the safety and effectivity of hydroxychloroquine + azithromycin to treat COVID-19 symptoms in primary care patients.
- Trial name
- AMBUCOV (NCT04954040)
- Testing
- Hydroxychloroquine Pill + Azithromycin Pill, SOC
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Neonatal Respiratory Distress
A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure
The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an alternative to other forms of non-invasive ventilation mechanism to provide continuous distending pressure to preterm infants.
- Trial name
- NCT04051762
- Testing
- High flow nasal cannula vs. Nasal continuous positive airway pressure
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ramy Saleh Morsy
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Acute Respiratory Distress Syndrome
Mechanical Power Normalized to Compliance in ARDS
Mechanical power (MP) is a summary variable, which includes static and dynamic respiratory parameters, is associated with ventilator-induced lung injury.
- Trial name
- NCT05761626
- Testing
- MP/Crs assessment < = 0.48 J/min/ml/cmH2O
- Where
- Argentina
- Volunteers
- 39 people
- Sponsor
- Ramos Mejía Hospital
COVID, Acute Respiratory Distress Syndrome
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome
This study aims to find out whether the use of angiotensin II, which is a drug to raise blood pressure has been approved by European Medical Agency in August 2019, as an add-on medication to increase blood pressure in patients…
- Trial name
- ACES (NCT04408326)
- Testing
- Angiotensin II, Interleukin-1 receptor antagonist
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Respiratory Distress Syndrome
Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle
Mortality rates in children with pediatric acute respiratory distress syndrome (PARDS) are higher in Asia compared to other regions.
- Trial name
- NCT03504176
- Testing
- Ventilation bundle
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- KK Women's and Children's Hospital
SARS-CoV2 Infection, COVID-19 Acute Respiratory Distress Syndrome
Impact of COVID-19 SARS-CoV-2 Variability in ICU Hospitalized Patients With Severe Disease
Background:The impact of the emergence of SARS-CoV-2 variants on the severity and clinical outcomes of COVID-19 is controversial.
- Conditions
- SARS-CoV2 Infection, COVID-19 Acute Respiratory Distress Syndrome, Mutation
- Trial name
- SEVARVIR (NCT05162508)
- Testing
- Nasopharyngeal swab
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome
Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome
In mechanically ventilated patients the PaO2/FiO2 ratio might not be the best reflection of the severity of ARDS. It does not incorporate variables and settings used during mechanical ventilatory support such as the positive end…
- Trial name
- NCT03946189
- Testing
- Obtaining arterial blood gases
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- American University of Beirut Medical Center
Covid19, Corona Virus Infection
Inhaled Aviptadil for the Treatment of COVID-19 in Patients at High Risk for ARDS
The world is currently experiencing a coronavirus (CoV-2) pandemic. A new (SARS)-CoV infection epidemic began in Wuhan, Hubei, China, in late 2019; originally called 2019- nCoV the virus is now known as SARSCoV- 2 and the disease…
- Conditions
- Covid19, Corona Virus Infection, ARDS, Aviptadil
- Trial name
- NCT04536350
- Testing
- Aviptadil 67μg
- Where
- 2 sites in Switzerland
- Volunteers
- 83 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Bronchopulmonary Dysplasia, Infant,Premature
Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia.
This study evaluates the addition of budesonide to poractant alfa to prevent bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome.
- Conditions
- Bronchopulmonary Dysplasia, Infant,Premature, Respiratory Distress Syndrome
- Trial name
- NCT03521063
- Testing
- Budesonide, Poractant Alfa, Saline
- Where
- Mexico
- Volunteers
- 108 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
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