Clinical trials: RECTAL NEOPLASMS, open to volunteers
Colorectal Cancer Screening, Fecal Immunochemical Test
Head to Head Trial of Mailed Cologuard to Mailed FIT
The objective of this study is to measure the comparative effectiveness of mailed outreach of two stool based tests, multi-target stool DNA (Cologuard) and the fecal immunochemical test (FIT) in screening eligible adults ages…
- Conditions
- Colorectal Cancer Screening, Fecal Immunochemical Test, Multi-target Stool DNA, Colorectal Cancer (CRC)
- Trial name
- NCT06931860
- Testing
- Cologuard, Fecal Immunochemical Test
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Diego
Gastric Cancer, Colorectal Cancer
Prospective Assessment of Alignment Between Multimodal Artificial Intelligence and Multidisciplinary Team Decisions in Gastrointestinal Oncology
This prospective, single-center observational study will evaluate the concordance between a multimodal artificial intelligence system and multidisciplinary team decisions in patients with gastrointestinal tumors.
- Conditions
- Gastric Cancer, Colorectal Cancer, Gastrointestinal Cancer
- Trial name
- NCT07746830
- Testing
- Multidisciplinary Team Clinical Decision Assessment, Multimodal Artificial Intelligence-Based Clinical Decision Assessment
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Colorectal Cancer
A Prospective Cohort Study on Colorectal Cancer Screening in Community Population
This study will validate the real world results of polygene methylation detection in colorectal cancer in a large prospective community cohort.
- Trial name
- NCT05485077
- Where
- China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Locally Advanced Rectal Carcinoma
Modulated Electro-Hyperthermia in Combination With Multimodal Therapy for Locally Advanced Rectal Cancer
The goal of this clinical trial is to investigate if the addition of modulated electro-hyperthermia (mEHT) improves tumor down-staging and pathological response in adult patients (20 years and above) with locally advanced rectal…
- Trial name
- mEHT (NCT07372300)
- Testing
- Hyperthermia
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Shih-Kai Hung
Ampulla of Vater Carcinoma, Appendix Carcinoma
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
This clinical trial is being done to learn whether using the proactive, graduated dose modification algorithm for leucovorin, 5-fluorouracil (5-FU), and oxaliplatin (FOLFOX) (PAGODA) algorithm to guide chemotherapy dosing for the…
- Conditions
- Ampulla of Vater Carcinoma, Appendix Carcinoma, Carcinoma of Unknown Primary With Gastrointestinal Profile, Colon Carcinoma
- Trial name
- NCT07283939
- Testing
- PAGODA algorithm, Oxaliplatin, Folinic Acid
- Where
- 368 sites in United States, Guam and 1 more
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Cancer Stage II, Rectal Cancer Stage III
Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial
The goal of this clinical trial is to test meal-timing as a novel and sustainable interventional approach during cancer treatment to improve therapeutic response and metabolic health in an understudied population.
- Conditions
- Rectal Cancer Stage II, Rectal Cancer Stage III, Breast Cancer Stage I, Rectal Cancer Stage IV
- Trial name
- NCT06802172
- Testing
- Time-restricted eating, Questionnaire Administration, Biospecimen Collection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Neoplasms, Sedentary Behavior
An Intervention to Reduce Sedentary Behavior and Promote Physical Activity in Colorectal Cancer Chemotherapy
This single-group feasibility study develops and evaluates an intervention designed to reduce sedentary behavior and promote physical activity in patients with colorectal cancer undergoing chemotherapy.
- Trial name
- NCT07845877
- Testing
- Sedentary behavior reduction intervention for patients with colorectal cancer undergoing chemotherapy
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Solid Cancer, Gastric (Cardia, Body) Cancer
Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients
In this study, the drug capecitabine is investigated. Capecitabine is commonly used to treat breast, colon, and stomach cancers. Capecitabine is taken in tablet form.
- Conditions
- Solid Cancer, Gastric (Cardia, Body) Cancer, Esophageal Cancer, Colorectal Cancer (CRC)
- Trial name
- ESCAPE (NCT07114627)
- Testing
- Blood sampling for pharmacokinetics
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erasmus Medical Center
Solid Tumor, Adult, Lung Adenocarcinoma
TP53 R248Q TCR-T Cell Therapy for Advanced Solid Tumor
To evaluate the safety and efficacy of T cell therapy with mutated TP53 R248Q specific TCR transduction in patients with advanced solid tumor expressing the TP53 R248Q mutation and the HLA-A*11:01 allele.
- Conditions
- Solid Tumor, Adult, Lung Adenocarcinoma, Pancreas Cancer, Colorectal Cancer
- Trial name
- NCT06619886
- Testing
- Autologous, engineered T Cells targeting TP53 R248Q
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Refractory Metastatic Colorectal Cancer
Amplitude Modulated Radiofrequency Electromagnetic Field Treatment Combined With TAS-102 (Lonsurf) and Bevacizumab in Refractory Metastatic Colorectal Cancer
Combined chemotherapy and radiofrequency electromagnetic field treatment for patients with liver dominant refractory metastatic colorectal cancer
- Trial name
- Live-RF (NCT05991102)
- Testing
- Radiofrequency electromagnetic field treatment
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer, Prostate Cancer
Holistic Acupuncture for Patients With Chemotherapy Induced Nausea
The study explores whether acupuncture as a supplement to conventional antiemetic medicine is superior in reducing the level of chemotherapy induced nausea compared to conventional anitemetic medicine alone.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Gynaecologic Cancer
- Trial name
- NCT07201194
- Testing
- Holistic acupuncture and acupressure, Standard medical treatment
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
Colorectal Neoplasms, Colorectal Cancer
Epidemiological and Molecular Colorectal Cancer Registry
This is a Registry that invites patients undergoing colorectal surgery for colorectal cancer. Epidemiological data is collected.
- Trial name
- EMR-CRC (NCT02781337)
- Where
- Argentina
- Volunteers
- 2,100 people
- Sponsor
- Hospital Italiano de Buenos Aires
Colorectal Neoplasms
A Prospective Study to Evaluate the Diagnostic Accuracy of Computer-aided Diagnosis (CADx) System in Real-time Characterization of Colorectal Neoplasia
The investigators hypothesize that a newly developed CADx system will have a higher diagnostic accuracy in predicting histopathology of colorectal neoplasia than both expert and junior endoscopists.
- Trial name
- CADx (NCT05414383)
- Testing
- CADx
- Volunteers
- 510 people
- Sponsor
- Chinese University of Hong Kong
Selected Advanced Solid Tumors, Colorectal Cancer (CRC)
SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors
This Phase 1, open-label study will evaluate two investigational radiopharmaceuticals in adults with selected advanced or metastatic solid tumors.
- Conditions
- Selected Advanced Solid Tumors, Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Biliary Tract Cancer (BTC)
- Trial name
- NCT07812805
- Testing
- SKL35501, SKL35502
- Where
- 5 sites in United States, South Korea
- Volunteers
- 100 people
- Sponsor
- SK Life Science, Inc.
Breast Carcinoma, Cervical Carcinoma
The Ohio State University (OSU) SCREEN Community Program
This clinical trial develops and tests how well a multi-level intervention (MLI), The Ohio State University (OSU) SCREEN Community Program, works to increase screening and follow-up for breast, cervical and colorectal (CRC)…
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma
- Trial name
- NCT06666192
- Testing
- Cancer Screening, Discussion, Educational Activity
- Where
- United States
- Volunteers
- 2,067 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Solid Tumors, Non-Small Cell Lung Cancer
Phase Ib Trial of HS-20117 in Combination With Other Drugs in Advanced Solid Tumors
HS-20117 is a fully-human EGFR-MET immunoglobulin G1(IgG1)-like bispecific antibody. The purpose of study is to evaluate the safety, tolerability, efficacy, PK profile and immunogenicity of HS-20117 in combination with other…
- Conditions
- Solid Tumors, Non-Small Cell Lung Cancer, Colorectal Cancer
- Trial name
- HS-20117 (NCT06621563)
- Testing
- HS-20117 combined HS-20093, HS-20117 combined Platinum-containing chemotherapy, HS-20117 combined HS-20093 and 5-FU
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Hansoh BioMedical R&D Company
Colorectal Cancer, Diabetes Mellitus
Glucose Homeostasis and Shared Genetic Factors in Colorectal Cancer
Colorectal cancer (CRC) and diabetes mellitus are two common diseases that frequently occur together and may share underlying genetic, metabolic, and immune-related mechanisms.
- Conditions
- Colorectal Cancer, Diabetes Mellitus, Glucose Homeostasis
- Trial name
- BRIDGE-CRCDM (NCT07648589)
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Colorectal Cancer
A Real-World Study of Neoadjuvant/Conversion Therapy for Colorectal Cancer With Chemotherapy And Anti-Angiogenic Targeted Agents
Fruquintinib is already the standard third-line treatment for metastatic colorectal cancer, but the efficacy of fruquintinib in neoadjuvant and conversion therapy for locally advanced/advanced colorectal cancer has not yet been…
- Trial name
- NCT06470178
- Testing
- corhot1: chemotherapy combined with fruquintinib, corhot2: chemotherapy combined with fruquintinib
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Wuhan University
Ovarian Neoplasms, Breast Neoplasms
Establishment of a Tumor Bank for Blood Samples
Establishment of a tumor bank, consisting of blood samples of tumor patients and healthy people as controls. The blood samples will be collected systematically together with the corresponding clinical data.
- Conditions
- Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia
- Trial name
- NCT01763125
- Testing
- Blood collection
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Colorectal Neoplasms Malignant, Lymph Node Excision
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%.
- Conditions
- Colorectal Neoplasms Malignant, Lymph Node Excision, Chemoradiotherapy
- Trial name
- NCT05129774
- Testing
- Radical surgery with PALND, Radical surgery without PALND
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
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