Clinical trials: REM Behavior Disorder
REM Sleep Behavior Disorder, Neurodegeneration
Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder
This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in…
- Trial name
- NCT04048603
- Where
- Hong Kong
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease, REM Sleep Behavior Disorder
Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder
This is a prospective cohort study to evaluate degenerative changes in the brain by performing functional imaging analysis in patients with RBD and its correlations with clinical symptoms and dopaminergic degeneration.
- Trial name
- NCT02984137
- Testing
- testing, evaluation, sampling
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
REM Sleep Behavior Disorder, Parkinson Disease
A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease
To investigate whether 24 months of idebenone may reduce the progression from Prodromal Parkinson disease (PPD) to Parkinson disease (PD).
- Trial name
- SEASEiPPD (NCT04152655)
- Testing
- Idebenone
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
REM Sleep Behavior Disorder
Gut Microbiota in the Progression of Alpha-synucleinopathies
The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.
- Trial name
- NCT05353868
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 490 people
- Sponsor
- Chinese University of Hong Kong
REM Sleep Behavior Disorder
Neuroplasticity in RBD
REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple…
- Trial name
- NCT05471960
- Testing
- Natural progression over time
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
REM Sleep Behavior Disorder (iRBD)
The Syn-Sleep Study
In collaboration with approximately 8 centers that specialize in iRBD we will recruit a total of 80 individuals for the study. All subjects will be enrolled into a 2-year longitudinal study where skin biopsies will be performed…
- Trial name
- NCT05757206
- Testing
- Syn-One Test
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- CND Life Sciences
Post Traumatic Stress Disorder, Sleep Disorder
Study of the Correlation Between Post-traumatic Stress Disorder and Paradoxical Sleep Behavior Disorder
Post-Traumatic Stress Disorder is a psychiatric disorder that occurs after a traumatic event and is estimated to affect 5 to 12% of the general population.
- Trial name
- TRAUMA-TCSP (NCT06221865)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
REM Sleep Behavior Disorder
PREdictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study
REM Sleep Behavior Disorder (RBD) is a REM sleep parasomnia first described in 1986 and characterized by the loss of physiological muscle atonia typical of REM sleep and by the presence of abnormal, sometimes violent, motor…
- Trial name
- FARPRESTO (NCT05262543)
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Cagliari
Sleep Paralysis, Narcolepsy Type 1
Meditation-Relaxation (MR Therapy) for Sleep Paralysis.
The aim of the study is to evaluate, with a small-scale pilot study, the efficacy of Meditation Relaxation therapy for Sleep Paralyses in patients with narcolepsy.
- Trial name
- MR_Therapy (NCT04483310)
- Testing
- MR therapy., breathing-distraction exercise
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Usl di Bologna
REM Sleep Behavior Disorder, Parkinson's Disease
Evolution of RBD in PD
About 60% of Parkinson's Disease (PD) patients have REM sleep Behavior Disorder (RBD), a parasomnia characterized by partial or complete loss of REM sleep muscle atonia and dream-enacting behaviors, usually associated to vivid…
- Trial name
- NCT03047408
- Testing
- Video polysomnography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Narcolepsy, Cataplexy
Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder
Up to 50% of Narcolepsy-cataplexy (NC) patients suffer from REM sleep behavior disorder (RBD), a parasomnia. A strong link was found between RBD and impulse control disorders (ICD) in Parkinson disease (PD) patients.
- Trial name
- NC-TCSP-IRMf (NCT03425214)
- Testing
- fMRI, Videopolysomnography, NC (narcolepsy-cataplexy)
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease, Prodromal Stage
Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands
The goal of this clinical trial is to investigate the feasibility if a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in patients with isolated Rapid Eye Movement…
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Parkinsonian Disorders
- Trial name
- Slow-SPEED-NL (NCT06193252)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Radboud University Medical Center
REM Sleep Behavior Disorder, Parkinson Disease
Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease
To investigate whether a year of rasagiline may reduce the progression from idiopathic REM sleep behavior disorder (RBD) to Parkinson's disease (PD).
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Synucleinopathies
- Trial name
- NCT05611372
- Testing
- Rasagiline
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sleep Disorder Rem Sleep Behavior, Parkinson's Disease, Lewy Body
Establishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder
We hypothesise that a real-time quaking induced conversion assay for the detection of pathological alpha-synuclein (α -syn RTQuIC) can be used to differentiate between cases of idiopathic REM-sleep behaviour disorder (RBD) and…
- Trial name
- NCT04266457
- Testing
- No Intervention
- Where
- United Kingdom
- Sponsor
- University of Edinburgh