Clinical trials: REM Sleep Parasomnias
REM Sleep Behaviour Disorder
Microstructural and Sodium 7 Tesla Brain MRI in Idiopathic REM Sleep Behaviour Disorder
By 2030 the number of patients with Parkinson's Disease (PD) would increase by 56% affecting 1 out of 120 people older than 45 years-old.
- Trial name
- SODISLEEP (NCT05976971)
- Testing
- 7T MRI
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Nightmare, Insomnia
INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention
The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether…
- Conditions
- Nightmare, Insomnia, PTSD, TBI
- Trial name
- INSIGHT (NCT07288593)
- Testing
- NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns.
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
REM Sleep Behavior Disorder, Isolated REM Sleep Behavior Disorder
Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others
The goal of this observational study is to explore the unmet needs and the psychosocial impact of isolated REM Sleep Behavior Disorder (iRBD) on patients and their significant others.
- Trial name
- NCT07498452
- Where
- 8 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Universita di Verona
Rapid Eye Movement Sleep Behavior Disorder
RBD Longitudinal as Prognostic for PD
Purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the pre-symptomatic stage of Parkinson's disease (PD).
- Trial name
- RBD6YR (NCT00817726)
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
REM Sleep Behavior Disorder
Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder
The purpose of this study is to determine whether the use of the drug ramelteon decreases the symptoms of REM Sleep Behavior Disorder.
- Trial name
- NCT01401413
- Testing
- ramelteon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sleep Medicine Centers of WNY
Parkinson Disease, Idiopathic, REM Sleep Behavior Disorder
Parkinson's Disease Biomarker Study
The primary objective of this study is to determine whether data acquired from a remote monitoring approach can reliably identify and track motor symptoms in prodromal PD and clinical PD.
- Trial name
- PDBS (NCT06812702)
- Testing
- Observational, Skin Biopsy
- Where
- 4 sites in Canada
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Ronald Postuma
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Sleep Disorder, Sleep Disorder Parasomnia
Mainz Register of Patients With Sleep Disorders
Prospective longitudinal observational registry study of all patients with sleep disorders treated in the Mainz Comprehensive Epilepsy and Sleep Medicine Center with the focus on the course of the disease and quality of life.
- Conditions
- Sleep Disorder, Sleep Disorder Parasomnia, Narcolepsy, Sleep Apnea
- Trial name
- MAINZ-SLEEPREG (NCT05321355)
- Testing
- Implantation of vagus nerve stimulation according to clinical indication
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Johannes Gutenberg University Mainz
Parkinson Disease (PD)
L-THEANINE AND MEDITERRANEAN DIET ON RBD, GI FUNCTION, AND INFLAMMATION IN PARKINSON'S DISEASE
Parkinson's disease is a progressive neurological disorder associated with severe dopaminergic neuron loss in the substantia nigra pars compacta.
- Trial name
- NCT07682532
- Testing
- Dietary Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Medipol University
Narcolepsy Type 1, Hypnagogic Hallucinations
Imagery Control Therapy and Lucid Dreaming for REM-Related Symptoms in Narcolepsy
This randomized controlled trial evaluated the efficacy of a cognitive behavioral intervention based on lucid dreaming training and imagery control therapy for reducing REM-related symptoms in patients with narcolepsy type 1.
- Conditions
- Narcolepsy Type 1, Hypnagogic Hallucinations, Sleep Paralysis, REM Sleep Intrusion Symptoms
- Trial name
- ICLDR-NAR Tria (NCT07609537)
- Testing
- Cognitive Behavioral Therapy for Narcolepsy (CBT-NAR) With Lucid Dreaming and Imagery Control Therapy, Sleep Hygiene Education and Structured Clinical Follow-up
- Where
- Colombia
- Volunteers
- 98 people
- Sponsor
- Institute of Behavioral Sleep Medicine, Colombia
REM Sleep Behavior Disorder
DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER
This study aims at the constitution of a large cohort of adult subjects without Rapid eye movement (REM) sleep behavior disorder (RBD), among whom subjects with isolated REM sleep without atonia (RSWA) will be identified; their…
- Trial name
- DREAMER (NCT06140511)
- Testing
- Polysomnography
- Volunteers
- 600 people
- Sponsor
- Oasi Research Institute-IRCCS
REM Sleep Behavior Disorder
Effects of Tablet Computer-based Cognitive Training in Patients With Idiopathic REM Sleep Behavior Disorder
To evaluate the effectiveness of tablet computer-based cognitive training in patients with idiopathic REM sleep behavior disorder.
- Trial name
- NCT05256836
- Testing
- Tablet computer-based cognitive training program
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Insomnia Chronic, Narcolepsy
The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders
Carry out precise and effective neuromodulation interventions, and develop new neuromodulation technologies for sleep disorders.
- Conditions
- Insomnia Chronic, Narcolepsy, REM Sleep Behavior Disorder
- Trial name
- NCT06797284
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital of Soochow University
REM Sleep Behavior Disorder
Establish a National Registry of REM Sleep Behavior Disorder
In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.
- Trial name
- NCT03671798
- Where
- Hong Kong
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Rapid Eye Movement Sleep Behavior Disorder
Effect of Acupuncture for Rapid Eye Movement Sleep Behavior Disorder
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia that is characterized by abnormal behaviours occurring during REM sleep（a sleep stage）, often as dream enactments that can cause injury.
- Trial name
- NCT06606418
- Testing
- Acupuncture group
- Volunteers
- 30 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Parkinson Disease, REM Sleep Behavior Disorder
Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder
This is a prospective cohort study to evaluate degenerative changes in the brain by performing functional imaging analysis in patients with RBD and its correlations with clinical symptoms and dopaminergic degeneration.
- Trial name
- NCT02984137
- Testing
- testing, evaluation, sampling
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Post Traumatic Stress Disorder, Sleep Disorder
Study of the Correlation Between Post-traumatic Stress Disorder and Paradoxical Sleep Behavior Disorder
Post-Traumatic Stress Disorder is a psychiatric disorder that occurs after a traumatic event and is estimated to affect 5 to 12% of the general population.
- Trial name
- TRAUMA-TCSP (NCT06221865)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
REM Sleep Behavior Disorder
Prodromal Markers of First-degree Relatives of Patients With Psychiatric Disorders Comorbid With RBD
REM sleep behavior disorder (typical or 'idiopathic' RBD, iRBD) is a novel and distinct parasomnia characterized by recurrent dream enactment behaviours and polysomnographic features of loss of normal REM-sleep related muscle…
- Trial name
- NCT03595475
- Where
- 2 sites in Hong Kong
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
REM Behavior Disorder
The Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)
To assess the effects of a daily single oral dose of 20 mg tasimelteon compared to baseline on events of dream enactment on patients with REM Behavior Disorder, as measured by a daily log.
- Trial name
- RBD (NCT05922995)
- Testing
- Tasimelteon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Dementia With Lewy Bodies, Parkinson Disease
5-HT RBD REM Sleep Behavior Disorder
This project will test the hypotheses that people with 5-HT RBD have systemic alpha- synuclein pathology, prodromal DLB signs, and brainstem lesions in regions that control REM sleep.
- Conditions
- Dementia With Lewy Bodies, Parkinson Disease, REM Sleep Behavior Disorder
- Trial name
- NCT06467461
- Testing
- Skin biopsy, Speech testing, Ultra high field 7T MRI
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Minnesota