Clinical trials: RENAL INSUFFICIENCY, CHRONIC
Chronic Kidney Disease
Ticagrelor and Anti-inflammatory Effects
Antiplatelet treatment in patients with end stage renal disease (ESRD) on hemodialysis (HD) is still challenging because of bleeding and thrombotic complications.
- Trial name
- NCT02406911
- Testing
- Ticagrelor
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Kyunghee University Medical Center
Chronic Kidney Disease (Stages 4 and 5)
Kidney RISE: Randomized Integrated Supportive CarE Trial
The purpose of study is to investigate whether adding palliative care to usual chronic kidney disease (CKD) care improves symptoms and quality of life for people with CKD.
- Trial name
- NCT07741357
- Testing
- Kidney RISE
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- NYU Langone Health
Renal Transplant Rejection, Chronic Kidney Diseases
Pathology and Imaging in Kidney Allografts
This study will perform multi-parametric renal MRI in 70 patients with a renal transplant who are undergoing a clinically indicated biopsy of their transplant.
- Conditions
- Renal Transplant Rejection, Chronic Kidney Diseases, Fibrosis
- Trial name
- PIKA (NCT03780101)
- Testing
- Multi-parametric renal MRI
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- NHS Greater Glasgow and Clyde
Chronic Kidney Disease, Proteinuria
A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines
The goal of this study is to establish whether use of a digital intervention can improve adherence and alignment with the Kidney Disease: Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) 2024 Guidelines.
- Conditions
- Chronic Kidney Disease, Proteinuria, Blood Pressure Control, Congenital Anomalies of the Kidneys and Urinary Tract
- Trial name
- NCT07561957
- Testing
- Use of an electronic digital Application
- Where
- 2 sites in Ireland
- Volunteers
- 80 people
- Sponsor
- St. James's Hospital, Ireland
Kidney Disease, Chronic, Renal Insufficiency, Chronic
Probiotic Supplementation and Disease Progression in CKD: A Randomized Trial
The goal of this clinical trial is to learn whether probiotic supplementation can slow disease progression in patients with moderate to severe chronic kidney disease (CKD).
- Conditions
- Kidney Disease, Chronic, Renal Insufficiency, Chronic, Gut Dysbiosis, Uremic Toxins
- Trial name
- PRO-CKD (NCT06863194)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Chronic Kidney Disease Stage 5
Shared Decision Making for Choosing renAl Replacement Therapy in Chronic Kidney Disease Patients
Shared decision making (SDM) is an approach where clinicians and patients make decisions together using the best available evidence.
- Trial name
- SDM-ART (NCT04976166)
- Testing
- Education
- Where
- 19 sites in South Korea
- Volunteers
- 1,194 people
- Sponsor
- Seoul National University Hospital
Renal Failure Chronic Requiring Hemodialysis
Performance Comparison of Revaclear With Larger Dialyzer
The purpose of the study is to show equivalent performance of the Revaclear dialyzer when compared to a dialyzer with larger membrane surface area.
- Trial name
- Revacom HD (NCT01722695)
- Testing
- Dialyzer comparison
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Vantive Health LLC
Chronic Kidney Diseases
Pyrophosphate and Arterial Calcification in Chronic Kidney Disease
Arterial calcifications start at early stages of chronic kidney disease (CKD) and are associated to cardiovascular mortality. Pyrophosphate (PPi) is an endogenous compound, which stops the mineralization process in bones and is…
- Trial name
- Predical (NCT04950439)
- Testing
- Collect blood sample
- Where
- France
- Volunteers
- 242 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cardiovascular Diseases, Kidney Failure, Chronic
Pharmacokinetics of Dabigatran Etexilate (Pradaxa®) During Haemodialysis
The current study will allow the assessment of pharmacokinetics, pharmacodynamics, elimination rate and clearance of dabigatran etexilate during and following haemodialysis in ESRD patients.
- Trial name
- NCT01241539
- Testing
- Dabigatran etexilate
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Boehringer Ingelheim
Chronic Kidney Disease, Glomerular Filtration Rate
The Relationship Between Renal Functions and Multi Drug Resistant Organisms
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in patients receiving invasive mechanical ventilation (MV).
- Conditions
- Chronic Kidney Disease, Glomerular Filtration Rate, Drug Resistance
- Trial name
- NCT04833231
- Where
- Turkey (Türkiye)
- Volunteers
- 133 people
- Sponsor
- Konya Numune Hospital
Cardiovascular Disease, Chronic Kidney Disease
Vascular Risk After Kidney Transplantation
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease progression after kidney transplant.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Diabetes, Vitamin D Deficiency
- Trial name
- NCT00374595
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- University of Nebraska
Chronic Kidney Disease (CKD), Hyperkalemia (HK)
A Two-Part, Single-Blind, Phase 3 Study Evaluating the Efficacy and Safety of Patiromer for the Treatment of Hyperkalemia (OPAL)
The purpose of this study was to evaluate the efficacy and safety of patiromer (investigational drug) in the treatment of hyperkalemia (high serum potassium).
- Trial name
- OPAL (NCT01810939)
- Testing
- Patiromer
- Where
- 58 sites in United States, Croatia and 8 more
- Volunteers
- 243 people
- Sponsor
- Relypsa, Inc.
Complication of Renal Dialysis, End Stage Renal Disease
A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen implant (SeCI; Sirogen), a single dose prophylactic treatment delivered intraoperatively at the time of surgical creation of an…
- Conditions
- Complication of Renal Dialysis, End Stage Renal Disease, End Stage Kidney Disease, ESRD
- Trial name
- ACCESS2 (NCT05425056)
- Testing
- Sirolimus
- Where
- 22 sites in United States, United Kingdom
- Volunteers
- 136 people
- Sponsor
- Vascular Therapies, Inc.
Renal Impairment
Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis
The primary objective was to evaluate the incidence of clinically significant hypocalcemia following multiple 120 mg subcutaneous doses of denosumab in patients with severe chronic kidney disease (CKD) and CKD on dialysis
- Trial name
- NCT01464931
- Testing
- Denosumab
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- Amgen
ESRD
Nutrition, Inflammation and Insulin Resistance in End Stage Renal Disease-Aim 2
By 2030 an estimated 2 million people in the US will need dialysis or transplantation for advanced kidney failure. An even more disturbing statistic is that mortality in End Stage Renal Disease (ESRD) is six times higher than in…
- Trial name
- INSPIRED (NCT02278562)
- Testing
- anakinra, actos
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Anemia of End Stage Renal Disease
TARGTEPO Treatment for Anemia in End Stage Renal Disease (ESRD) Patients Undergoing Peritoneal Dialysis (PD)
The objectives of this study are to assess safety and to evaluate the biologic activity of TARGTEPO treatment in Peritoneal Dialysis patients
- Trial name
- NCT02378662
- Testing
- MDGN201 TARGTEPO
- Where
- 2 sites in Israel
- Volunteers
- 2 people
- Sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
Chronic Renal Failure, Haemodialysis, Haemodiafiltration, Haemofiltration
Catheter Dysfunction Rate in Patients Undergoing Kidney Replacement Therapy. Evaluation of the Safety and Efficacy of Anti-reflux Valves Without Heparin Lock Solution
Catheter dysfunction and infections are the most common complications observed among patients with dialysis catheters for long-term dialysis ( CDLD ) .
- Conditions
- Chronic Renal Failure, Haemodialysis, Haemodiafiltration, Haemofiltration, Kidney Replacement Therapy, Catheter Infection, Catheter Dysfunction, Catheter Related Bloodstream Infections
- Trial name
- DUKE (NCT06259266)
- Testing
- Anti-reflux valve for dialysis catheter
- Where
- France
- Sponsor
- University Hospital, Clermont-Ferrand
Thrombosis
Risk of Central Venous Stenosis in Patients With Chronic Renal Failure After IJ Line Placement
The purpose of this study is to compare the difference in thrombosis as a result of internal jugular (IJ) catheters versus peripherally inserted central catheter (PICC) lines.
- Trial name
- NCT01988766
- Where
- United States
- Volunteers
- 1,424 people
- Sponsor
- University of Chicago
Anemia, Chronic Kidney Disease
STIMULATE Study: Anemia Correction and Health-related Quality of Life (HRQoL) Outcomes in Elderly Chronic Kidney Disease (CKD) Patients
Treatment of anemia associated with chronic kidney disease (CKD) during 36 weeks with safety follow up phase of 52 weeks
- Trial name
- NCT00364845
- Testing
- Darbepoetin alfa
- Volunteers
- 51 people
- Sponsor
- Amgen
Chronic Kidney Disease
Observational Study on Chronic Kidney Disease Treatment With a Ketosteril Supplemented Protein-restricted Diet
The purpose of this study is to characterise the patient and disease profile under the influence of a protein-restricted diet supplemented with keto acids/amino acids (KA/AA), focusing on the progression of chronic renal…
- Trial name
- NCT02649205
- Testing
- Observational study: Supplemented protein-restricted diet
- Where
- Hungary
- Volunteers
- 164 people
- Sponsor
- Fresenius Kabi
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