Clinical trials: RENAL INSUFFICIENCY, CHRONIC
Renal Insufficiency, Chronic
Targeting Central Pulsatile Hemodynamics in Chronic Kidney Disease
Heart failure (HF) is an epidemic and is a major burden on the US healthcare system. The most common cardiovascular endpoint is HF. Thus, novel interventions to prevent HF in chronic kidney disease (CKD) are highly desirable.
- Trial name
- NCT02791906
- Testing
- ISMN, Vitamin C
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Chronic Kidney Diseases
miRNA in Chronic Kidney Diseases
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD).
- Trial name
- NCT06316284
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Chronic Renal Failure
FGF23 Reduction : Efficacy of a New Phosphate Binder in CHronic Kidney Disease
The purpose of this study is to evaluate in Chronic Kidney Disease (CKD) patients not on dialysis and who have an Fibroblast growth factor 23 (FGF23) serum levels elevated, the effect of non calcic phosphate binder: sevelamer…
- Trial name
- FRENCH (NCT01220843)
- Testing
- Sevelamer carbonate
- Where
- 15 sites in France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4
Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease
Chronic Kidney Disease (CKD) induces many metabolic troubles especially for the advanced CKD (stage 3b-5) patients and their prevalence and importance grow with the deterioration of the glomerular filtration rate (GFR).
- Conditions
- Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Fatigue
- Trial name
- PIONEER (NCT04330807)
- Testing
- Handgrip fatigability test, Questionnaires
- Where
- France
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier le Mans
Chronic Kidney Disease
Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics and Effect on Renal Potassium Clearance
The purpose of this study is to investigate the safety and tolerability of LY2623091 after multiple oral dosing in healthy men and women of non-childbearing potential.
- Trial name
- NCT01237899
- Testing
- LY2623091, Eplerenone
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
End Stage Renal Disease, Living Donor Kidney Transplantation
Social Networks and Renal Education: Promoting Transplantation
There are significant and persistent disparities in access to kidney transplantation and as a result most patients with end stage renal disease receive hemodialysis (HD).
- Conditions
- End Stage Renal Disease, Living Donor Kidney Transplantation, Renal Dialysis
- Trial name
- SNARE (NCT03536858)
- Testing
- COACH (Communicating about Choices in Transplantation)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Temple University
Chronic Kidney Disease(CKD), Hyperphosphatemia
Long-term Effects of the New Nordic Renal Diet in Patients With Moderate Chronic Kidney Disease
As Chronic Kidney Disease (CKD) progresses normophosphatemia is maintained by increasing the per nephron urinary phosphorus excretion.
- Conditions
- Chronic Kidney Disease(CKD), Hyperphosphatemia, Blood Pressure
- Trial name
- CKD (NCT04579315)
- Testing
- Intervention group; NNRD group
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bo Feldt-Rasmussen
Hyperparathyroidism, Secondary
Extension Study of Etelcalcetide in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease (CKD) on Hemodialysis
This study is designed to describe the long-term safety and efficacy of etelcalcetide (AMG 416) for the treatment of SHPT in adults with CKD on hemodialysis.
- Trial name
- NCT01785875
- Testing
- Etelcalcetide
- Where
- 208 sites in United States, Australia and 15 more
- Volunteers
- 891 people
- Sponsor
- Amgen
Chronic Kidney Diseases, Microplastics
Biomonitoring of Internal Exposure to MNPLs, and Its Effects, in Blood of Patients With Chronic Kidney Disease (CKD)
Micro and nanoplastics (MNPLs) effects on human heath is still preliminary. Chronic kidney disease (CKD) participants, specially does patients submitted to hemodialysis, are a population high exposed to plastics.
- Conditions
- Chronic Kidney Diseases, Microplastics, Nanoplastics, Genotoxic Damage
- Trial name
- NCT05155267
- Testing
- Biomonitoring study to detect MNPLs in biological samples and study of their health effects
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
Staphylococcal Infections, Chronic Kidney Failure
Evaluation of Manufacturing Lot of StaphVAX
This study answers a U.S. Food and Drug Administration requirement for evaluation in people of a manufacturing lot of vaccine. Subjects receive one dose of one lot of vaccine.
- Trial name
- NCT00211900
- Testing
- S. aureus Type 5 & 8 Capsular Polysaccharide Vaccine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Nabi Biopharmaceuticals
End Stage Renal Disease, Hemolysis
Ventilatory Functions and Physical Intolerance in ESRD Adolescents: Response to Program of Walking With Dogs
adolescents with chronic renal failure going on hemodialysis usually complain many problems including compromised ventilation, early fatigue, early physical intolerance, and bad life quality.
- Trial name
- NCT06861816
- Testing
- incentive spirometer and walking with dog, training by incentive spirometer only
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Kidney Failure, Chronic
Pharmacokinetics, Pharmacodynamics, and Safety Study of Ticagrelor in Hemodialysis Patients and Healthy Subjects
A phase I, open-label study comparing the pharmacokinetics, pharmacodynamics, safety and tolerability of ticagrelor in hemodialysis patients to healthy subjects with normal renal function.
- Trial name
- NCT02022748
- Testing
- ticagrelor
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Kidney Disease, Muscle Weakness
Vitamin D 2 to Dialysis Patients
Vitamin D is necessary for healthy bones. Vitamin D is made in our skin when we are exposed to sunlight, but it is also found in foods that we eat and in vitamin pills.
- Conditions
- Kidney Disease, Muscle Weakness, Pain, Fractures, Bone
- Trial name
- D2D (NCT00535158)
- Testing
- Ergocalciferol (Vitamin D 2)
- Volunteers
- 18 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury
Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury
The risk for postoperative acute kidney injury (pAKI), as for any other postoperative complications (PC), comes from a number of interactions between a patient's health before surgery, strength to tolerate surgery and influences…
- Trial name
- NavigateAKI (NCT02114138)
- Testing
- pathogenesis of perioperative acute kidney injury, urine collection
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Florida
Lower Extremity Edema, Congestive Heart Failure(CHF)
Pedal Pump Clinical Trial on Edema V1
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
- Trial name
- NCT07760363
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David McVay
Anemia, Kidney Failure
Dynepo Infrequent Dosing Study
The purpose of this study is to demonstrate non-inferiority of efficacy between twice weekly and once weekly dose schedule of Dynepo in previously erythropoietin (EPO)-naive patients, as measured by haemoglobin at week 24 and…
- Trial name
- NCT00450333
- Testing
- Dynepo (Epoetin delta), Dynepo
- Where
- 53 sites in Austria, Belgium and 5 more
- Volunteers
- 407 people
- Sponsor
- Shire
Renal Failure, Chronic Kidney Disease Requiring Chronic Dialysis
High-protein Oral Supplement Improves Normalized Protein Catabolic Rate and Inflammation Markers
The investigators propose to determine the impact of high-protein beverages on protein status and inflammation markers among CKD patients undergoing hemodialysis.
- Trial name
- NCT05227755
- Testing
- Soy protein isolate, Whey protein isolate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Kidney Failure, Chronic, End-Stage Renal Disease
Comparison of Nocturnal Hemodialysis (NHD) and Short Daily Hemodialysis (DHD) With the NxStage® System One™
The purpose of this study is to determine whether or not nocturnal hemodialysis is equivalent to short daily hemodialysis on a per treatment basis, using the NxStage System One in the home setting.
- Trial name
- NCT00667511
- Testing
- NxStage System One
- Where
- 9 sites in United States
- Volunteers
- 58 people
- Sponsor
- NxStage Medical
Liver Transplant, Complications, Renal Failure Acute Chronic
Intraoperative Assessment of Renal Tissue Oxygenation Using NIRS
The kidney is one of the most vital organs in the human body. Renal perfusion is primarily supplied by the renal artery, while the removal of metabolites and venous drainage are provided by the renal vein.
- Trial name
- NCT07409532
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Inonu University
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