Clinical trials: RESPIRATORY SYNCYTIAL VIRUS (RSV)
Premature Birth, Respiratory Disease
Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants
Approximately 8% of all births occur between 30-36 weeks of gestation ('moderate-late' prematurity). Respiratory tract infections (RTI) and wheezing illnesses disproportionally affect preterm infants resulting in a 1.5-2 fold…
- Conditions
- Premature Birth, Respiratory Disease, Respiratory Tract Infections, Preterm Birth
- Trial name
- LONG LOVE (NCT05618769)
- Testing
- LONG LOVE Framework
- Where
- Netherlands
- Volunteers
- 330 people
- Sponsor
- Franciscus Gasthuis
Respiratory Syncytial Virus Infections, RSV Infection
RESCEU: Defining the Burden of RSV Disease
This observational study will determine the burden of RSV disease in at least 2000 healthy infants over 6 years until November 2026.
- Trial name
- NCT03698084
- Testing
- venepuncture, nasopharyngeal swab
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Oxford
RSV Infection, Quality of Life
Infant RSV Infections and Health-related Quality of Life of Families
Until today, there is only little information available on how severe RSV infection leading to hospitalisation of the infant impacts the quality of life of affected families.
- Conditions
- RSV Infection, Quality of Life, Infant ALL, Caregiver Burden
- Trial name
- ResQFamily (NCT05550545)
- Testing
- cohort study
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Global Foundation for the Care of Newborn Infants
RSV Infection
Human Challenge Study to Evaluate the Efficacy of MV-012-968 Vaccine
The purpose of this research study is to evaluate whether the investigational, live attenuated, intranasally delivered vaccine MV-012-968 ('study vaccine') may have prophylactic efficacy against symptomatic RSV infection when…
- Trial name
- NCT04690335
- Testing
- MV-012-968
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meissa Vaccines, Inc.
Respiratory Syncytial Virus (RSV)
Safety and Immunogenicity of an Intranasal Vaccine for Respiratory Syncytial Virus in Seronegative Children 6-36 Months
This study evaluates an investigational vaccine that is designed to protect humans against infection with respiratory syncytial virus (RSV) and is administered as a nasal spray.
- Trial name
- NCT04909021
- Testing
- Investigational RSV vaccine MV-012-968 (Dosage 1), Investigational RSV vaccine MV-012-968 (Dosage 2), Investigational RSV vaccine MV-012-968 (Dosage 3; single-dose)
- Where
- 12 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Meissa Vaccines, Inc.
Respiratory Syncytial Virus (RSV)
A Study to Evaluate the Efficacy of an RSV F Vaccine in Older Adults
The purpose of this study is to demonstrate the efficacy of the RSV F vaccine at a dose of 135µg via intramuscular (IM) injection in the prevention of moderate-severe RSV-associated lower respiratory tract disease (RSV-LRTD) in…
- Trial name
- NCT02608502
- Testing
- RSV-F Vaccine
- Where
- 60 sites in United States
- Volunteers
- 11,850 people, healthy volunteers welcome
- Sponsor
- Novavax
RSV Infection, Bronchiolitis
Severity of RSV Infections in Twins
Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection (LRTI) in the pediatric population worldwide.
- Trial name
- TwinSeVeRS (NCT05070975)
- Testing
- Epidemiology
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Syncytial Virus (RSV)
Placebo- Controlled Study to Evaluate the Safety and Immunogenicity of the RSV-F Vaccine in Elderly Adults
The purpose of this study is to evaluate the safety and immunogenicity of the RSV- F Vaccine in elderly subjects, as well as rate the incidence of medically- attended RSV disease in vaccine and placebo recipients.
- Trial name
- NCT02266628
- Testing
- RSV-F Vaccine
- Where
- 10 sites in United States
- Volunteers
- 1,599 people, healthy volunteers welcome
- Sponsor
- Novavax
Respiratory Syncytial Virus (RSV)
Safety and Immunogenicity of the RSV-F Vaccine in Older Adults Previously Treated With the Same Vaccine or Placebo in the Prior Year.
This study will enroll subjects who received the RSV F vaccine or placebo in the earlier study (RSV-E-201, Year 1) and re-randomize them to receive either vaccine or placebo in a second season.
- Trial name
- NCT02593071
- Testing
- RSV-F Vaccine
- Where
- 10 sites in United States
- Volunteers
- 1,330 people, healthy volunteers welcome
- Sponsor
- Novavax
RSV Infection
A Phase 2a Study to Evaluate EDP-938 in the Virus Challenge Model
A randomised, Phase 2a, double-blind, placebo-controlled study to evaluate the safety, pharmacokinetics and antiviral activity of multiple doses of orally administered EDP-938 in healthy subjects infected with RSV-A Memphis 37b.
- Trial name
- NCT03691623
- Testing
- EDP-938 Dose 1, EDP-938 Dose 2, EDP-938 Dose 3
- Where
- United Kingdom
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Rhinovirus, RSV Infection
Impact of the Covid-19 on RSV
The magnitude of seasonal RSV epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific winter plans with…
- Trial name
- IPCoVRS-2 (NCT05348616)
- Testing
- epidemiology
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
RSV Infection
Impact of the Covid-19 on Respiratory Syncytial Virus (RSV) Epidemic
The magnitude of seasonal Respiratory Syncytial Virus (RSV) epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific…
- Trial name
- IPCoVRS (NCT04944160)
- Testing
- Medical records analysis, Comparison of cohorts
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Syncytial Virus (RSV)
Absorption, Metabolism, and Excretion (AME) Study of [14C]EDP-938 in Healthy Male Subjects
A Phase 1, Open-label Study of the absorption, metabolism, and excretion of a single oral dose of [14C]EDP-938 in healthy male subjects.
- Trial name
- NCT04927793
- Testing
- EDP-938
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
SARS-CoV-2 Infection, Influenza
Household Study of COVID-19, Influenza and RSV Burden, Transmission Dynamics and Viral Interaction in South Africa
The study aims to characterize the community burden (including the clinical features) and transmissibility of SARS-CoV-2 within the context of a functional antibody response.
- Conditions
- SARS-CoV-2 Infection, Influenza, Respiratory Syncytial Virus (RSV)
- Trial name
- PHIRST-C (NCT05277298)
- Where
- 2 sites in South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute for Communicable Diseases, South Africa
Influenza Viral Infections, RSV Infection
Analytical Performances and Clinical Impact of the Roche Cobas® Liat Influenza A/B & RSV Assay in the Management of Adult and Pediatric Patients Attending the Emergency Room
Molecular techniques for respiratory virus detection have already shown benefits in terms of sensitivity gained in comparison to conventional techniques.
- Trial name
- NCT05105191
- Testing
- Roche Cobas® Liat Influenza A/B & RSV assay
- Where
- 4 sites in Belgium
- Volunteers
- 280 people
- Sponsor
- Erasme University Hospital
RSV Infection
Drug-Drug Interaction Study Between EDP-938, Tacrolimus, Dabigatran, Rosuvastatin and Midazolam in Healthy Subjects
A Non-Randomized, Open-Label, Three-Part, Drug-Drug Interaction Study to Evaluate the Effects of tacrolimus, dabigatran, rosuvastatin and midazolam on the Pharmacokinetics and Safety of EDP-938 in Healthy Subjects
- Trial name
- NCT04498741
- Testing
- EDP-938, Tacrolimus, Dabigatran
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Respiratory Syncytial Virus (RSV), Infant Death
Community-based RSV Surveillance in Infant Mortality: Minimally Invasive Tissue Sampling Study in Karachi, Pakistan
In order to assess the burden of respiratory syncytial virus on infant mortality in Pakistan, nasopharyngeal swab sampling and minimally invasive tissue sampling (MITS) will be conducted on deceased infants under 6 months of age.
- Conditions
- Respiratory Syncytial Virus (RSV), Infant Death, Community-Acquired Infections
- Trial name
- RSV-MITS (NCT05047549)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Aga Khan University
Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV)
Infection With Respiratory Syncytial Virus in Infants
IRIS (Infection with RespIratory Syncytial Virus) is an observational, multi-center study enrolling infants with severe RSV infection and healthy controls.
- Conditions
- Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus-bronchiolitis
- Trial name
- IRIS (NCT04925310)
- Where
- 2 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Hannover Medical School
RSV Infection, Respiratory Syncytial Virus Infections
RESCEU Study: Defining the Burden of Disease of Respiratory Syncytial Virus in Europe in Infants
The REspiratory Syncytial virus Consortium in EUrope (RESCEU) is an Innovative Medicine Initiative (IMI) effort funded by the EU under the H2020 framework to define and understand the burden of disease caused by human respiratory…
- Conditions
- RSV Infection, Respiratory Syncytial Virus Infections, RSV Bronchiolitis
- Trial name
- NCT03627572
- Testing
- No intervention
- Where
- 5 sites in Finland, Netherlands and 2 more
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
RSV Infection
Drug-Drug Interaction Study Between Fluconazole and EDP-938 in Healthy Subjects
A Non-Randomized, Open-Label, Drug-Drug Interaction Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics and Safety of EDP-938 in Healthy Subjects
- Trial name
- NCT04871724
- Testing
- EDP-938, Fluconazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc