Clinical trials: RNA Virus Infections
HIV Infections
Directly Observed Therapy for HIV Infected Adolescents
Adherence to a doctor-prescribed anti-HIV drug regimen is crucial in the management of HIV infection. In previous studies with tuberculosis patients, directly observed therapy (DOT), a strategy in which patients are observed…
- Trial name
- NCT00259389
- Testing
- Directly observed therapy (DOT)
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Risk Behavior, Alcohol Use Disorder
TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk
Ecological momentary interventions (EMI), which use phones to deliver messages to reduce alcohol use and related risk behaviors during or prior to drinking events, can help to address triggers in real-time.
- Conditions
- Risk Behavior, Alcohol Use Disorder, HIV Infections
- Trial name
- TRAC-ER (NCT05576350)
- Testing
- Smartphone Based Alcohol Monitoring (SAM), Tracking and Reducing Alcohol Consumption (TRAC), TRAC-ER
- Where
- 2 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
HIV Infections
HIV Prevention for Youth With Severe Mental Illness
This 4-year competing continuation will extend the follow-up for 750 subjects enrolled in a randomized interventions trial, Project STYLE: "HIV Prevention for Youth with Severe Mental Illness" (R01, MH 63008).
- Trial name
- NCT00496691
- Testing
- Family-based HIV prevention program
- Where
- United States
- Volunteers
- 718 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Drug Safety, Respiratory Syncytial Virus Infections
A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of MDT-637 in Healthy Volunteers
The purpose of this study is to determine the range of single inhaled doses of a new dry powder product, MDT-637, that are safe and well-tolerated.
- Trial name
- NCT01355016
- Testing
- MDT-637
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- MicroDose Therapeutx, Inc
Influenza, Respiratory Viral Infection
A Study to Evaluate the Safety and Efficacy of XC221 in Patients With Uncomplicated Influenza or Other Acute Viral Upper Respiratory Infections
The main purpose of the study was to evaluate the effectiveness of XC221, tablets, at a dose of 200 mg/day compared to placebo in patients with uncomplicated influenza or other acute respiratory viral infections (ARIs).
- Trial name
- NCT05544916
- Testing
- XC221
- Where
- 13 sites in Russia
- Volunteers
- 260 people
- Sponsor
- Valenta Pharm JSC
Diphtheria, Pertussis
A Phase I/II Clinical Trial of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed
This is a randomized, positive-controlled phase I/II clinical trial to evaluate the safety and preliminary immunogenicity of the Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine…
- Conditions
- Diphtheria, Pertussis, Tetanus, Poliomyelitis
- Trial name
- NCT07891104
- Testing
- Diphtheria, Tetanus, Acellular Component Pertussis and Sabin Inactivated Poliomyelitis Vaccine Adsorbed, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine, Diphtheria, Tetanus and Acellular Component Pertussis Combined Vaccine+Inactivated Poliomyelitis Vaccine Made From Sabin Strains
- Where
- 3 sites in China
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Influenza, Virus Diseases
Immunogenicity, Safety and Optimal Dose Finding Study of Recombinant Influenza H5N1 Vaccine in Healthy Young Adults
UMN-0501 is a purified recombinant influenza HA vaccine (A H5N1/Vietnam/1203/2004). The purpose of the present study is to evaluate immunogenicity, safety and optimal dose among three different doses of UMN-0501 following two…
- Trial name
- NCT00980447
- Testing
- UMN-0501
- Where
- 2 sites in Japan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- UMN Pharma Inc.
Immunization; Infection|Transplantation Infection|Influenza, Influenza
High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater)
This will be a follow-up study to the "Comparison of High Dose vs. Standard Dose Influenza Vaccine in Lung Allograft Recipient" study (DMID Protocol Number 22-0014) at Vanderbilt University Medical Center.
- Trial name
- NCT07192458
- Testing
- Fluzone High Dose Inactivated Influenza Vaccine, Fluzone Standard Dose Inactivated Influenza Vaccine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
HIV Infection, HIV Seronegativity
Cohort Study of Volunteers That Have Participated to Preventive HIV-1 Vaccine Trials
This cohort study should provide an exhaustive overview on long-term safety of various preventive HIV-vaccines administered in phase I and II clinical trials to healthy volunteers of the ANRS network.
- Trial name
- NCT00789789
- Where
- France
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
COVID-19
Immunogenicity and Safety of Booster Immunization of COVID-19 Vaccine (Vero Cell), Inactivated (Omicron Variant) in Healthy People Aged 18 Years and Above
This is a randomized, double-blind, active-controlled Phase Ⅲ clinical trial, as well as an immuno-bridging clinical trial by parallel testing previous serum after primary immunization of COVID-19 vaccine (Vero cell), inactivated…
- Trial name
- NCT05381350
- Testing
- COVID-19 Vaccine (Vero cell), Inactivated (Omicron variant), COVID-19 Vaccine (Vero cell), Inactivated (CZ strain)
- Where
- China
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Sore-throat, Common Cold
A Randomized, Triple-blind, Placebo-controlled Study to Evaluate the Effects of a Throat Spray on the Incidence and Duration of Sickness
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of Beekeeper's Naturals Propolis Immune Support Throat Spray on the incidence and duration of sickness over a 16-week period.
- Trial name
- NCT07246850
- Testing
- Beekeeper's Propolis Throat Spray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beekeeper's Naturals Inc
Influenza
Efficacy of Candidate Influenza Vaccine MVA-NP+M1 in Adults
A Phase 2b Study to Determine the Efficacy of Candidate Influenza Vaccine MVA-NP+M1 in Adults aged 18 years and over. To assess the effect of MVA-NP+M1 on the reduction of laboratory confirmed influenza when given as an adjunct…
- Trial name
- NCT03880474
- Testing
- MVA-NP+M1, Saline
- Where
- 9 sites in Australia
- Volunteers
- 2,364 people, healthy volunteers welcome
- Sponsor
- Barinthus Biotherapeutics
Zika Virus Disease (Disorder)
Zika in Infants and Pregnancy (ZIP)
The overall objective of this multisite, multicountry Zika in Infants and Pregnancy (ZIP) study is to assess the strength of the association between Zika virus infection (ZIKV) during pregnancy and adverse maternal/fetal outcomes…
- Trial name
- NCT02856984
- Where
- 10 sites in Brazil, Colombia and 4 more
- Volunteers
- 6,461 people, healthy volunteers welcome
- Sponsor
- RTI International
Olfactory Dysfunction, Covid19
Acupuncture for Olfactory Dysfunction in Infected COVID-19 Patients
In this a 12-week, single blinded, randomized sham controlled, and cross-over clinical trial. It will be conducted to explore the safety and efficacy of acupuncture for olfactory dysfunction in infected COVID-19 patients in Hong…
- Trial name
- NCT04959747
- Testing
- acupuncture
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Hong Kong Baptist University
Enterovirus Infections
Detection of Enterovirus Genotypes by CRISPR Technology
CRISPR-enterovirus detection system was constructed in this study for detection variety genotypes of enterovirus rapidly in children suspected or diagnosed as enterovirus infection.
- Trial name
- NCT04535648
- Testing
- Non-invasive detection method: CRISPR techonology
- Sponsor
- Children's Hospital of Fudan University
HIV Infections
Perspective Memory and Executive Functions in HIV+ Patients
The primary goal of this observational study is to evaluate prospective memory in HIV+ patients compared to healthy subjects. The secondary goal is to examine the relationship between prospective memory and Hot Cognition…
- Trial name
- (3514) (NCT05752578)
- Testing
- Neuropsychological testing
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Covid19
Geriatric Care for Older People Hospitalised for COVID-19
Current COVID-19 pandemic implies regular treatment adaptation by physician, according to scientific publication evolution. Older adults are particularly affected by COVID-19, with the higher severe form prevalence and the higher…
- Trial name
- COVAGERT (NCT04947943)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Montpellier
COVID-19
Reducing COVID-19 Related Hospital Admission in Elderly by BCG Vaccination
Bacillus Calmette-Guérin (BCG) vaccine not only protects against tuberculosis, but has also been shown to induce protection against various infections with a viral aetiology, leading to significant reductions in morbidity and…
- Trial name
- NCT04417335
- Testing
- BCG vaccine
- Where
- 2 sites in Netherlands
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
HIV, AIDS
Exploring the Impact of HIV and ART on Knowledge, Attitudes and Practices in Reproductive Health in Lilongwe, Malawi
The aim of this study is to identify reproductive health priorities among individuals living with HIV.This study also seeks to explore factors that influence fertility, family planning, and sexual behavior among individuals with…
- Trial name
- HIV KAP (NCT02667808)
- Testing
- Focus Group, Questionnaire
- Where
- Malawi
- Volunteers
- 562 people
- Sponsor
- Emory University