Clinical trials: RNA Viruses
Hepatitis C
The Prime Study - Comparing Hepatitis C Care and Treatment in a Primary Health Care Service With a Tertiary Hospital
The Prime Study is a randomised trial investigating models of care for hepatitis C in the era of direct acting antiviral (DAA) therapy.
- Trial name
- NCT02555475
- Testing
- community based hepatitis C care and treatment
- Where
- 8 sites in Australia, New Zealand
- Volunteers
- 140 people
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
COVID-19
Oropharyngeal Immunoprophylaxis With High Polyphenolic Olive Oil as Clinical Spectrum Mitigating Factor in COVID-19.
Immunomodulation of local immune response at the oropharyngeal mucosa can hypothetically activate mucosal immunity, which can difficult SARS-CoV-2 main immune evasion mechanisms in early stages of the disease and send an…
- Trial name
- COVID-19 (NCT05685901)
- Testing
- High polyphenolic olive oil. (Early harvest olive oil).
- Where
- Spain
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Hospital General Nuestra Señora del Prado
Hepatitis A
The Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines
The purpose of this Phase 4 trial is to assess the safety, immunogenicity, three-year immune persistence of inactivated hepatitis A vaccine (HAV) and live attenuated HAV vaccine.
- Trial name
- HAV (NCT01949857)
- Testing
- Attenuated HAV Vaccine, H2 Strain, Attenuated HAV Vaccine, L-A-1 Strain, Inactivated HAV Vaccine, Lu8 Strain
- Where
- China
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Kaposi Sarcoma, HIV Infections
An Evaluation of Tc 99m Tilmanocept by Intravenous (IV) and Subcutaneous (SC) Injection in Kaposi Sarcoma (KS)
To determine the safety of escalating IV doses of Tc 99m tilmanocept in HIV (human immunodeficiency virus) subjects with confirmed KS and to compare results obtained from subcutaneous and IV administrations of Tc 99m tilmanocept…
- Trial name
- NCT03157167
- Testing
- Tc99m-tilmanocept
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Navidea Biopharmaceuticals
HIV Infections
Improving HIV Diagnosis, Linkage to Care, and Prevention Services With HIV Point-of-Care Nucleic Acid Tests
This project (NCT04880200) will develop, implement, and evaluate models for use of point-of-care nucleic acid testing (POC NAT) among HIV-negative persons seeking HIV testing, PEP, and PrEP and HIV-positive persons in community…
- Trial name
- GAIN (NCT04880200)
- Testing
- POC NAT & Adherence Intervention
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of Washington
COVID-19, COVID-19 Respiratory Infection
Association of Circulating ACE2 Levels With COVID-19
COVID-19 cases are rising substantially in Jordan. Since this is a novel virus, there is still much to be investigated surrounding its pathophysiology in order to attempt to find suitable treatments or better decision-making in…
- Trial name
- NCT05205707
- Testing
- ACE serum levels
- Where
- Jordan
- Volunteers
- 261 people
- Sponsor
- Jordan University Hospital
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Covid19
Covid-19 Infection in After Vaccination
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China. It rapidly spread, resulting a global pandemic in March 2020.
- Trial name
- NCT05033834
- Testing
- covid-19 vaccines registered in Egypt
- Where
- 3 sites in Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
HIV Infections, Hepatitis B Virus
A Surveillance Program for the Detection of Hepatitis B Virus (HBV) Resistance to Tenofovir in HIV-HBV co-Infected Patients
Human immunodeficiency virus/Hepatitis B virus (HIV/HBV) co-infections are frequently observed due to shared routes of transmission, with reported figures indicating 6-9% of HIV-infected individuals in developed countries are…
- Trial name
- NCT00660361
- Where
- Australia
- Volunteers
- 92 people
- Sponsor
- Bayside Health
Hiv
The Effect on Lipid Profile of Switching to Delstrigo in HIV Positive Patients
This is an open label, randomised, two-arm switch study over 48 weeks in which virally suppressed participants on a stable combined ART regimen will be randomised (1:1) to an immediate switch to 3TC/TDF/DOR (immediate switch arm…
- Trial name
- META-D (NCT05289986)
- Testing
- DELSTRIGO 100Mg-300Mg-300Mg Tablet
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Covid19
Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 Patients
This clinical trial aims to ascertain the impact of GSE and Xylitol (XLEAR) in decreasing the time of negativisation in PCR testing in patients with COVID-19.
- Trial name
- NCT04854486
- Testing
- GSE and Xylitol
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
Post COVID-19
Special Chinese Medicine Out-patient Programme for Discharged COVID-19 Patients
According to the ongoing observational studies and the Chinese Medicine practice guideline for COVID-19 patients, the discharged patients with COVID-19 still exhibits certain clinical symptoms such as fatigue, poor appetite…
- Trial name
- NCT04544605
- Testing
- Individualized-Chinese herbal medicine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hong Kong Baptist University
COVID-19
A Clinical Trial of a Recombinant Adenovirus 5 Vectored COVID-19 Vaccine (Ad5-nCoV) With Two Doses in Healthy Adults
This is a clinical trial to evaluate the safety and immunogenicity of a recombinant adenovirus 5 vectored COVID-19 vaccine (Ad5-nCoV) with two doses and with different adminstration routes in healthy adults aged 18 years and…
- Trial name
- NCT04552366
- Testing
- Ad5-nCoV
- Where
- China
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China
Covid-19 Infection
Oxford/AstraZeneca COVID-19 Vaccine Effectiveness in England
This is a retrospective cohort study to assess the real world effectiveness of the Oxford/AstraZeneca COVID-19 vaccine in England.
- Trial name
- RAVEN (NCT05047822)
- Where
- United Kingdom
- Volunteers
- 18,373,714 people
- Sponsor
- AstraZeneca
HIV Infections
Doravirine for Obese Persons on Integrase Inhibitors and Tenofovir Alafenamide
The purpose of this study was to determine if people with HIV and obesity taking an antiretroviral treatment regimen containing an integrase strand transfer inhibitor (INSTI) with (tenofovir alafenamide/emtricitabine (TAF/FTC)…
- Trial name
- NCT04636437
- Testing
- Doravirine 100 Mg, Integrase strand transfer inhibitors, Tenofovir alafenamide/emtricitabine
- Where
- 27 sites in United States
- Volunteers
- 147 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Human Immunodeficiency Virus
Bringing South African Men Into HIV Counseling and Testing and Care
This clinical trial seeks to determine if male-centered recruitment increases men's testing for HIV and whether or not individualized introduction to clinics increases male engagement in treatment for HIV.
- Trial name
- NCT03794245
- Testing
- Men-Centered HIV Testing, Linkage to Care for HIV+ Men, Clinic-based HIV Testing
- Where
- South Africa
- Volunteers
- 1,806 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV Infections
Non-interventional Study on Use of Darunavir With Ritonavir in Clinical Practice
The purpose of this non-interventional study is a description of use of darunavir in daily practice, in retrospective and perspective manner.
- Trial name
- NCT01375881
- Testing
- darunavir/ritonavir plus background regimen
- Volunteers
- 31 people
- Sponsor
- Janssen-Cilag S.p.A.
SARS-CoV
Validation of a Rapid, Non-invasive Point-of-care IVD Test for Diagnosis of SARS-COV-2 (COVID-19) Infection
A prospective non-interventional study to evaluate the performance of EASYCOV IVD as point-of-care (POC) test by comparing SARS-CoV-2 positive patients with SARS-CoV-2 negative controls on paired specimens (nasopharyngeal swabs…
- Trial name
- EasyCov (NCT04583319)
- Testing
- EasyCov POC
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Firalis SA
COVID-19 Vaccines
Improving COVID-19 Vaccine Uptake in Nursing Homes
SARS-CoV-2 vaccine, now being administered to skilled nursing facility (SNF) residents and staff, has highly variable acceptance between facilities.
- Trial name
- NCT04732819
- Testing
- High touch multi-pronged behavioral intervention
- Where
- 4 sites in United States
- Volunteers
- 23,768 people
- Sponsor
- Brown University
HIV-1-infection, ART
Ph1 Study of FT538 Alone and With Vorinostat for Persistent Low-Level HIV Viremia
This is a single center Phase I clinical trial of FT538 administered intravenously (IV) once every 14 days for 4 consecutive doses for the reduction of the HIV reservoir in lymphoid tissue of HIV-infected individuals receiving…
- Conditions
- HIV-1-infection, ART, Cd4+ Lymphocyte Deficiency, Lymphoid Tissue; Infection
- Trial name
- NCT05700630
- Testing
- FT538, Vorinostat
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota