Clinical trials: RYGB
Hypoglycemia
CREON for the Treatment of Post-RYGB Hypoglycemia
Hypoglycemia is an increasingly recognized complication of Roux-en-Y gastric bypass (RYGB) that is poorly understood and difficult to treat.
- Trial name
- NCT02733848
- Testing
- Creon, Diet
- Volunteers
- 5 people
- Sponsor
- East Carolina University
Obesity, Morbid
Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass
Obesity is a major public health problem worldwide. Bariatric surgery has proved to be the most effective treatment of morbid obesity in terms of weight reduction and remission of co-morbid conditions during long-term follow-up.
- Trial name
- SADISLEEVE (NCT03610256)
- Testing
- SADI-S, RYGB
- Where
- 22 sites in France
- Volunteers
- 382 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Metabolic Disease
Conventional Vs Tailored Limb Lengths in Laparoscopic Roux-en Y Gastric Bypass Surgery
The study aims to investigate whether tailoring limb lengths based on the 1/3rd and 2/3rd concept improves clinical outcomes in Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) surgery compared to conventional limb lengths.
- Conditions
- Obesity, Metabolic Disease, Bariatric Surgery Candidate, Metabolic Surgery
- Trial name
- TAILO-R-YGB (NCT06756789)
- Testing
- Laparoscopic Roux-en Y Gastric bypass (RYGB)- Conventional approach, Laparoscopic Roux-en Y Gastric bypass (RYGB)- Tailored approach
- Where
- India
- Volunteers
- 40 people
- Sponsor
- GEM Hospital & Research Center
Bariatric Surgery
Multivitamin Support Following Bariatric Surgery
Bariatric surgery (BS), an effective treatment for severe obesity and its comorbidities, may result in micronutrient and vitamin deficiencies.
- Trial name
- NCT06152965
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Bioitalia srl
Bariatric Surgery, Morbid Obesity
The PREBA Study: Effect of Preoperative Weight Loss With a 14-day Low-calorie Diet on Surgical Procedure and Outcomes in Patients Undergoing RYGB Surgery
Bariatric guidelines recommend preoperative weight loss of 5% to reduce the risk of surgical complications. However, results in the literature on the improvement of surgical procedure and outcomes are still conflicting.
- Trial name
- NCT04433338
- Testing
- 14-day Low Calorie Diet
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Rijnstate Hospital
Post-bariatric Hypoglycemia
An Expanded Access Protocol to Provide Avexitide in Patients With Post-Bariatric Hypoglycemia
The Expanded Access Program will provide access to avexitide for people with post-bariatric hypoglycemia (PBH) following Roux-en-Y gastric bypass (RYGB) who meet the eligibility criteria for this program.
- Trial name
- NCT07582874
- Testing
- Avexitide
- Where
- 4 sites in United States
- Sponsor
- Amylyx Pharmaceuticals Inc.
Obesity
Evaluation of the Absorption Rate From Different Oral Fe-supplements in Obese Volunteers Pre- and Post-RYGB
Obese volunteers who have scheduled a gastric bypass (RYGB) in UZ Leuven will be asked to participate in a cross-over study using commercial available iron supplements.
- Trial name
- NCT02569593
- Testing
- Iron supplements, more specific Ferrodyn and Vista Ferrum
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- KU Leuven
Roux-en-Y Bariatric Surgery
Investigation of the Effects of Obesity Surgery on Appetitive Behaviour
Among all the existing ways to treat obesity (lifestyle, pharmacological), Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective.
- Trial name
- NCT02010385
- Testing
- Octreotide, Saline
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Postprandial Hypoglycemia
Canagliflozin in Postprandial Hyperinsulinemic Hypoglycemia (CANA-PHH-RYGB)
Roux-en-Y gastric bypass (RYGB) is the most common surgical procedure for morbid obesity. However, it can present serious late complications, like postprandial hyperinsulinemic hypoglycemia (PHH).
- Trial name
- CANA-PHH-RYGB (NCT04720859)
- Testing
- Canagliflozin 300 MG Oral Tablet
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Type II Diabetes Mellitus, Obesity
Metabolomics of Roux-en-Y Gastric Bypass (RYGB) With Gastrostomy
This study is an investigation of the "metabolomics of RYGB with gastrostomy."
- Trial name
- NCT00887302
- Testing
- Gastric Band, Gastric Sleeve, Gastrostomy Tube
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- East Carolina University
Obesity
RYGB and the Gastric Adipose Axis
The purpose of this study is to determine if interruption in gastric-adipose tissue axis signaling contributes to early improvements in oxidative stress, insulin sensitivity, and inflammation, and to determine if interruption of…
- Trial name
- NCT01474785
- Testing
- human ghrelin, very low calorie diet, Hyperinsulinemic/Euglycemic Clamp
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Vanderbilt University
Obesity
Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
It is estimated that up to 20% of patients who have Roux-en-Y Gastric Bypass (RYGB) surgery will not meet their weight loss goal, or may even regain some of the weight they initially lost.
- Trial name
- NCT00394212
- Testing
- Transoral Suturing
- Where
- 10 sites in United States
- Volunteers
- 77 people
- Sponsor
- C. R. Bard
Obesity, Hypoglycemia Post Gastric Bypass Surgery
GLP1R-imaging in Post-RYGB Hypoglycemia
In order to evaluate the difference in beta cell mass in patients with and without hyperinsulinemic hypoglycemia after Roux en Y gastric bypass (RYGB) investigators aim to compare quantitative PET imaging of the pancreas between…
- Conditions
- Obesity, Hypoglycemia Post Gastric Bypass Surgery, Hyperinsulinemic Hypoglycemia
- Trial name
- NCT05597475
- Testing
- GLP-1R PET
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Calcium Citrate Absorption, Calcium Carbonate Absorption
Comparison of the Absorption of Calcium Citrate and Calcium Carbonate in Patients With an RYGB, LSG, and OAGB
The precise impact of calcium absorption in relation to RYGB, SG, and OAGB remains under-researched in terms of statistical power and the diversity of BMS procedures considered.
- Trial name
- CALCOR-RSO (NCT06042985)
- Testing
- The absorption effect between calcium citrate and calcium carbonate
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Obesity, Morbid Obesity
DIT After RYGB - A Prospective Study
Bariatric surgery is the only satisfactory treatment for loss and weight maintenance in obese patients. This loss is a result of several factors that go beyond the simple anatomical abnormality of the gastrointestinal tract and…
- Conditions
- Obesity, Morbid Obesity, Bariatric Surgery
- Trial name
- DIT RYGB (NCT01759667)
- Testing
- A standard mixed Meal
- Where
- Brazil
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Hypoglycemia, Glucose Metabolism Disorders
Efficacy and Safety of Dasiglucagon for Treatment of Post-bariatric Hypoglycemia in Roux-en-Y Gastric Bypass (RYGB) Operated Adults
The objective of the trial is to assess the effect of single subcutaneous doses of dasiglucagon versus placebo on post-prandial plasma glucose nadir following a Mixed Meal Test in Roux-en-Y Gastric Bypass (RYGB) subjects
- Trial name
- NCT04824872
- Testing
- Dasiglucagon
- Sponsor
- Zealand Pharma
Obesity, Severe, Diabetes Mellitus, Type 2
Roux-en-Y Gastric Bypass (RYGB) Versus Omega-Loop Gastric Bypass (OLGB) Safety and Efficacy Short-term Study
The aim of this study is to compare the relative clinical outcomes between two variants of gastric bypass [Roux-en-Y Gastric Bypass (RYGB) or Omega-Loop Gastric Bypass (OLGB)] in metabolic surgery candidates with Body Mass Index…
- Trial name
- ROSESS (NCT02290418)
- Testing
- Roux-en-Y Gastric Bypass, Omega-Loop Gastric Bypass
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Nemocnice Břeclav, p.o.
Severe Obesity
Determinants of Fat Malabsorption After Roux-en-Y Gastric Bypass
The purpose of this study is to determine whether or not the length of the biliopancreatic limb of the Roux-en-Y anastamosis plays a critical role in the development of malabsorption after gastric bypass for treatment of severe…
- Trial name
- NCT01252511
- Testing
- RYGB for surgical treatment of severe obesity
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Diabetes Mellitus, Type II
Mechanisms of Glycemic Improvement After Gastrointestinal Surgery
This study is designed as a prospective clinical trial aimed at investigating the mechanisms behind observed improvements in type 2 diabetes mellitus (T2DM) following bariatric surgery.
- Trial name
- NCT01025999
- Testing
- No intervention
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Washington
Weight Loss
RYGB AL 150cm BPL 100cm vs RYGB AL 100cc BPL 150cm
A Roux-en-Y gastric bypass will be performed in all the cases. Patients will be randomized according the limb lengths: Group 1: Alimentary limb (AL) 150cm and biliopancreatic limb (BPL) 100cm Group 2: AL 100cm and BPL 150cm…
- Trial name
- NCT03838276
- Testing
- AL 150 BPL100, AL 100 BPL 150
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Elche