Clinical trials: Radiation Fibrosis
Breast Cancer
Prognostic Indicators for Radiation-induced Breast Fibrosis
To study the inflammatory response during and after radiotherapy, especially by measuring the concentration of an enzyme called autotaxin and its product LPA in the blood plasma.
- Trial name
- NCT05031065
- Testing
- Breast Cancer Radiotherapy
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- AHS Cancer Control Alberta
Keloid
Improving Keloids Using Targeted Ultraviolet-B Irradiation
Treatment of keloids with targeted Ultraviolet-Beta (UVB) radiation will improve the clinical appearance and induration of lesions.
- Trial name
- NCT03160053
- Testing
- NB-UVB
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Portal Hypertension, Chronic Liver Disease
Non-invasive Diagnosis of Portal Hypertension With Acoustic Radiation Force Impulse (ARFI)
The aim of this diagnostic study is to evaluate the efficacy of ARFI imaging (a specific type of ultrasound) in assessing the pressure of the portal vein (the major vein passing through the liver) and the amount of liver fibrosis…
- Trial name
- NCT01644656
- Testing
- ARFI ultrasound
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- VA Connecticut Healthcare System
Non Small Cell Lung Cancer (NSCLC)
Piloting the Feasibility of FLT-PET/CT Non-Small Cell Lung Cancer Managed With SBRT
Stereotactic body radiotherapy (SBRT) has emerged as one of the leading curative method for early stage non-small cell lung cancer (NSCLC).
- Trial name
- SBRT FLT-PET (NCT02456246)
- Testing
- FLT-PET
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University Health Network, Toronto
Keloid
Keloid Radiation Registry
Radiation therapy has been, and is being used in treatment of patients with keloid. Radiation is typically used as an adjunct to surgery in order to reduce the recurrence rate of keloid.
- Trial name
- NCT01457079
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Tirgan, Michael H., M.D.
Lung Disease, Interstitial, Idiopathic Pulmonary Fibrosis (IPF)
Artificial Intelligence (AI) Detection of Incidental Interstitial Opacity on Chest Radiography
The goal of this observational study is to learn how well an artificial intelligence (AI)-based chest X-ray analysis software can incidentally detect interstitial lung disease (ILD), which appears as interstitial opacity, on…
- Conditions
- Lung Disease, Interstitial, Idiopathic Pulmonary Fibrosis (IPF), Incidental Findings, Interstitial Lung Disease (ILD)
- Trial name
- NCT07686562
- Testing
- VUNO Med®-Chest X-ray™
- Where
- South Korea
- Volunteers
- 1,293 people, healthy volunteers welcome
- Sponsor
- Chung-Ang University Hospital
Radiation Pneumonitis
Risk Factors of Radiation Pneumonitis
A prospective observational study to evaluate clinical, dosimetrical, functional, and biological factors in predicting radiation pneumonitis.
- Trial name
- NCT00155909
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- National Taiwan University Hospital
Radiation Induced Fibrosis
Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients
This study will evaluate the efficacy of losartan (LOS), an FDA-approved transforming growth factor beta-1 (TGF-β1) blocker, to decrease radiation induced fibrosis (RIF) in the breast and the lung of breast cancer patients…
- Trial name
- NCT05637216
- Testing
- Losartan 25 milligram capsule
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Shaw Cancer Center
Malignant Neoplasm of Breast Stage I
Trial to Compare Radiation Fibrosis With Five Versus Three Fractions
Post meno-pausal women with T1 Breast cancers will be randomized to receive either 600 centiGray (cGy) X 5 over five consecutive days (arm 1) versus 800 cGy X 3 fractions given every other day (arm 2).
- Trial name
- NCT02755896
- Testing
- Arm 1 600 cGY x 5 fractions, Arm 2 800 cGY x 3 fractions
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Weill Medical College of Cornell University
Liver Neoplasms, Hepatic Cirrhosis
Radiotherapy With Iron Oxide Nanoparticles (SPION) on MR-Linac for Primary & Metastatic Hepatic Cancers
There is a high prevalence of hepatic cirrhosis in patients with hepatocellular carcinomas (HCC), or chemotherapy-induced hepatic atrophy or hepatosteatosis in patients with liver metastases associated with high risk of…
- Conditions
- Liver Neoplasms, Hepatic Cirrhosis, Hepatic Carcinoma, Liver Cancer
- Trial name
- NCT04682847
- Testing
- Ferumoxytol injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group
Radiation Pneumonitis, Endostatin
Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis
To verify the efficacy and safety of endostatin in the treatment of SRILI（symptomatic radiation-induced lung injury） and fibrosis.
- Trial name
- NCT03796364
- Testing
- Endostar, standard SRILI treatment
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xinqiao Hospital of Chongqing
Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
The Evaluation of Manual Therapy for the Prevention of Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
The subjects in this study are the patients with head and neck cancer after completion of the radiotherapy. Radiation-induced fibrosis is inevitable and there is no effective treatment to prevent it.
- Trial name
- NCT04850170
- Testing
- manual therapy, Speech therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Hepatitis C
Acoustic Radiation Force Impulse-Imaging in Comparison to Transient Elastography for Liver Fibrosis Staging in HCV
This study will evaluate the effectiveness of Acoustic Radiation Force Impulse (ARFI)- Imaging compared to Transient Elastography (FibroScan) in differentiating liver fibrosis in patients with chronic hepatitis C.
- Trial name
- NCT01113814
- Testing
- FibroScan, Acoustic Radiation Force Impulse (ARFI)- Imaging
- Where
- 9 sites in France, Germany and 1 more
- Sponsor
- Johann Wolfgang Goethe University Hospital
Local Neoplasm Recurrence, Distantly Metastatic Malignant Neoplasm
Partial Breast Versus no Irradiation for Women With Early Breast Cancer
All early breast cancer patients are offered adjuvant breast radiation therapy (RT) after breast conserving surgery for an early breast cancer.
- Conditions
- Local Neoplasm Recurrence, Distantly Metastatic Malignant Neoplasm, Death, Fibrosis Breast
- Trial name
- NCT03646955
- Testing
- No partial breast irradiation
- Where
- 17 sites in Chile, Denmark and 2 more
- Volunteers
- 926 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Esophageal Cancer, Radiation Pneumonitis
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology
Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs.
- Conditions
- Esophageal Cancer, Radiation Pneumonitis, Pulmonary Fibrosis, Respiratory Failure
- Trial name
- NCT03462524
- Testing
- Esophagectomy
- Where
- 2 sites in Ireland
- Volunteers
- 384 people
- Sponsor
- St. James's Hospital, Ireland
Radiation Toxicity, Fibrosis
Pilot Study of the Predictive Value of TREM1 Expression and Activation in Inflammation and Radio-induced Mammary Fibrosis
Breast cancer is the most common cancer in the world. Half of patients with such cancer are treated with radiation therapy. Some patients will develop cutaneous or subcutaneous fibrosis, more or less bothersome.
- Conditions
- Radiation Toxicity, Fibrosis, Breast Cancer
- Trial name
- TREM-1 (NCT04948840)
- Testing
- Blood sampling
- Where
- 3 sites in France, Luxembourg
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse, Luxembourg
Lung Cancer, Radiation Fibrosis
Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
The goal of this study is to investigate the efficacy of [68Ga]CBP8 to detect collagen deposition in radiation induced tissue injury.
- Conditions
- Lung Cancer, Radiation Fibrosis, Radiation Induced Lung Injury, Pancreas Cancer
- Trial name
- NCT04485286
- Testing
- [68Ga]CBP8
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Massachusetts General Hospital
Trismus, Radiation-induced Fibrosis
Physiotherapy for Radiation-induced Trismus
The purpose of this study is to assess the effect of two protocols of physiotherapeutic exercises in the maintenance and/or increase of the mandibular range of movement in patients suffering from head and neck cancer (HNC) who…
- Trial name
- NCT02094690
- Testing
- Therabite, Hyperboloid
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Cystic Fibrosis
Dynamic Chest X-ray With Simultaneous Spirometry
Dynamic chest X-ray (DCR) is a novel radiographic technique that enables us to visualise the movement of the chest and lungs in real-time by recording a series of x-ray images over 10-20 second interval.
- Trial name
- DynaSSaur (NCT06122051)
- Testing
- Dynamic chest x-ray, Spirometry
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust