Clinical trials: Radiation Fibrosis
Liver Fibrosis, Liver Cirrhosis
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Liver stiffness measurement (LSM) by non invasive methods is increasingly used to estimate liver fibrosis in patients with chronic liver diseases.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Viral Hepatitis, Liver Tumour
- Trial name
- NARFI (NCT01082419)
- Testing
- ARFI measurement
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Keloid, Scleroderma, Localized
Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix
This research study will evaluate the effectiveness of high dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis nuchae, old burn scars, granuloma annulare or related conditions.
- Conditions
- Keloid, Scleroderma, Localized, Acne Keloidalis, Scars
- Trial name
- NCT00129428
- Testing
- UVB Irradiation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan
Liver Cirrhosis, Refractory Ascites
Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study
Transjugular intrahepatic portosystemic shunt (TIPS) creation is an established minimally invasive treatment for complications of portal hypertension such as refractory ascites and variceal bleeding.
- Conditions
- Liver Cirrhosis, Refractory Ascites, Variceal Bleeding, Portal Hypertension
- Trial name
- FLIGHT (NCT07470515)
- Testing
- Fiber-Optic Navigation System
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University Innsbruck
Chronic Liver Disease
Postprandial Liver and Spleen Stiffness Measurements in the Noninvasive Diagnosis of Cirrhosis
This is a study that will evaluate the utility of measuring liver and spleen stiffness before and after a meal by a non invasive ultrasound based technologies called Fibroscan (Transient elastography) and acoustic radio-frequency…
- Trial name
- NCT03087344
- Testing
- Fibroscan and Acoustic Radiation Force Impulse, Fibroscan, Acoustic Radiation Force Impulse
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Connecticut Healthcare System
Crohn's Disease, Ultrasound
Ultrasound Stiffness Imaging in Crohn's Disease
The purpose of this study is to determine whether ultrasound-based assessment of intestinal stiffness in patients with Crohn's disease predicts the effectiveness of medical therapy or the need for surgical resection.
- Conditions
- Crohn's Disease, Ultrasound, Intestinal Fibrosis, Shear Wave Imaging
- Trial name
- NCT01666626
- Testing
- Ultrasound stiffness imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Chronic Liver Disease (CLD), Cancer
Chronic Liver Disease and Radiation-induced Second Primary Liver Malignancy
Cancer survivors are at a high risk to develop second primary malignancy (SPM) which constitutes a serious threat for them. Radiotherapy is the cornerstone for the management of many cancers as a locoregional treatment modality.
- Conditions
- Chronic Liver Disease (CLD), Cancer, Liver Fibrosis
- Trial name
- NCT06868394
- Testing
- radiotherapy, No intervention
- Where
- Egypt
- Volunteers
- 20,846 people
- Sponsor
- Suez Canal University
Keloid Scar
A Retrospective Evaluation of Superficial Radiation Therapy (SRT) and Keloid Scars.
Keloid formation in response to skin trauma inflicts about 18 million individuals. A key impediment in successful treatment of keloids is that the predominant treatments, particularly surgical excision and shaving, tend to…
- Trial name
- NCT03693924
- Testing
- SRT-100
- Volunteers
- 100 people
- Sponsor
- Sensus Healthcare
Neuroendocrine Carcinoma of Pancreas, Duodenum Carcinoma
Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After Pancreatoduodenectomy
The FIBROPANC-1 investigates the feasibility and safety of preoperative stereotactic radiotherapy of 4cm pancreas in patients undergoing pancreatoduodenectomy at high risk (>25%) of developing post operative pancreatic fistula…
- Conditions
- Neuroendocrine Carcinoma of Pancreas, Duodenum Carcinoma, Pancreas Neoplasm, Distal Cholangiocarcinoma
- Trial name
- FIBROPANC-1 (NCT05641233)
- Testing
- Stereotactic radiotherapy
- Where
- 2 sites in Netherlands
- Volunteers
- 33 people
- Sponsor
- Erasmus Medical Center
Radiation Pneumonitis
Mitigation of Radiation Pneumonitis, Fibrosis and Heart Toxicity With Nicorandil in Lung Cancer Patients
This project will test the effect of nicorandil to mitigate the lung damage that can occur as a side effect of radiation therapy for lung cancer.
- Trial name
- NCT02809456
- Testing
- Nicorandil
- Volunteers
- 50 people
- Sponsor
- Taipei Medical University WanFang Hospital
Pulmonary Fibrosis
Efficiency Study for Acute Radiation-induced and Chemotherapy-induced Pulmonary Fibrosis With Bevasizumab
Due to the radiosensitivity of the lung, radiation-induced and chemotherapy-induced pneumonitis and pulmonary fibrosis are frequent happened following cancer therapy.
- Trial name
- NCT01917877
- Testing
- Bevacizumab, Dexamethasone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qingdao Central Hospital
Breast Cancer, Lymphedema
Vitamin E and Pentoxifylline in Treating Women With Lymphedema After Radiation Therapy for Breast Cancer
RATIONALE: Vitamin E and pentoxifylline may be effective in decreasing lymphedema in women who have received radiation therapy for breast cancer.
- Trial name
- NCT00022204
- Testing
- vitamin E, pentoxifylline, quality-of-life assessment
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Radiation Lymphedema, Radiation Fibrosis
Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients
Radiation fibrosis syndrome (RFS) is a general side effect of radiation therapy (RT) which can adversely impact patients chronically over years typically triggered by an acute inflammatory state that evolves into chronic…
- Conditions
- Radiation Lymphedema, Radiation Fibrosis, Head and Neck Cancer
- Trial name
- PBM-LEF (NCT06708754)
- Testing
- Photobiomodulation (PBM) Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Radiation Dermatitis Acute, Radiation Dermatitis
Oral or Topical Catechins for Radiation Dermatitis
Introduction Radiation-induced dermatitis (RID), which includes both acute and chronic forms, affects up to 95% of patients undergoing radiation therapy.
- Conditions
- Radiation Dermatitis Acute, Radiation Dermatitis, Fibrosis; Skin
- Trial name
- OCTOPUS-RD (NCT07149506)
- Testing
- Epicatechin, Epigallocatechin Gallate (EGCG), Saline (0.9% NaCl)
- Where
- Mexico
- Volunteers
- 162 people
- Sponsor
- CARLOS FRANCISCO SAAVEDRA GARCIA
Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple
AI Assisted Detection of Chest X-Rays
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple, Pulmonary Consolidation, Pneumothorax
- Trial name
- AID-CXR (NCT06075836)
- Testing
- Cases reading, Ground truthing
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Cholangiocarcinoma, Cirrhosis
Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function
This phase I trial studies the side effects and the best dose of radiation therapy in treating patients with hepatocellular carcinoma, cholangiocarcinoma, or cancer that has spread from the original (primary) tumor to the liver…
- Conditions
- Cholangiocarcinoma, Cirrhosis, Hepatocellular Carcinoma, Metastatic Malignant Neoplasm in the Liver
- Trial name
- NCT02626312
- Testing
- Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Radiation Therapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Anal Cancer
Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy
A commercially available vaginal dilator set will be used as measuring device. The grading of vaginal stenosis will be determined as difference of the diameter of vaginal dilator to the baseline.
- Trial name
- DILANA (NCT04094454)
- Testing
- special tampon with a diameter of 28mm, standard tampon with a diameter of 12-13mm
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Juergen Debus
Visceral Stiffness, Liver Fibrosis
Visceral Stiffness Measurement Using Acoustic Radiation Force Impulse
The acoustic radiation force impulse (ARFI) technology provides real-time measurements of tissue stiffness. Aim: Using the ARFI ultrasonography, the investigators aims are to complete the correlation and validity studies between…
- Trial name
- ARFI (NCT01311934)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Bladder Fibrosis
Bladder ARFI (Acoustic Radiation Force Impulse) Study
Urinary bladder fibrosis (thickening and scarring) is fairly uncommon in children. Traditionally, the presence of urinary bladder fibrosis has been confirmed directly with bladder biopsy or using urodynamic testing.
- Trial name
- NCT01781832
- Testing
- ARFI-Derived Shear Wave Velocities
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Michigan
Fibrosis
Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen
The pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. Hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of…
- Trial name
- ORT-OXI-2009 (NCT01822405)
- Testing
- pentoxifylline with tocopherol, pentoxifylline+tocopherol + Hyperbaric Oxygen Therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario de Canarias