Clinical trials: Radiation Injury
Radiation Injuries, Cognitive Impairment
The Effect of Donepezil in Radiotherapy-related Cognitive Impairment.
Purpose: This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the therapeutic effects of donepezil in radiotherapy-related cognitive impairment.
- Trial name
- NCT03907371
- Testing
- Donepezil Hydrochloride
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Quality of Life, Relaxation During Radiation Therapy
Guided Meditation During Radiotherapy.
The purpose of this research is to gather information on the effects of Mindfulness-Based Intervention (MBI) on quality of life during and after radiation treatment. This study involves randomization.
- Conditions
- Quality of Life, Relaxation During Radiation Therapy, Cancer, Radiation Toxicity
- Trial name
- NCT04303013
- Testing
- Meditation, Standard of Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Cardiotoxicity, HER2-positive Breast Cancer
Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction
Breast cancer is the most common cancer in the United Kingdom (UK), but improvements in treatment mean 3 in 4 people survive for more than 10 years.
- Conditions
- Cardiotoxicity, HER2-positive Breast Cancer, Heart Failure, Cancer, Therapy-Related
- Trial name
- HER-SAFE (NCT05880160)
- Testing
- Phased withdrawal of heart failure medications
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University College, London
Breast Cancer
Early Prediction and Warning for Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
This multicenter clinical study aims to build an intelligent and accurate diagnosis and dynamic prediction and early warning model of cardiotoxicity due to anthracycline-based breast cancer chemotherapy, clarify the value of the…
- Trial name
- NCT06282796
- Testing
- Echocardiography
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- First Hospital of China Medical University
Mucositis, Hematopoietic Stem Cell Transplantation
Effects of Mesenchymal Stem Cell Supernatant on Prevention and Treatment of Skin/Mucosal Injury in Hematology Patients
This clinical trial is studying the effects of mesenchymal stem cell (MSC) culture supernatant on the prevention and treatment of mucosal injuries in patients undergoing hematopoietic stem cell transplantation (HSCT).
- Conditions
- Mucositis, Hematopoietic Stem Cell Transplantation, Chemotherapy-Induced Mucositis, Radiation-Induced Mucositis
- Trial name
- MSC-MucInj (NCT06599346)
- Testing
- Standard Care, MSC Supernatant + Standard Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The General Hospital of Western Theater Command
Prostate Cancer Metastatic, Radiotherapy Side Effect
Metastatic Prostate Cancer Men's Attitudes Towards Treatment of the Local Tumour and Metastasis Evaluative Research
Systemic therapy (i.e Androgen Deprivation Therapy with Docetaxel, Enzalutamide, Apalutamide or Abiraterone Acetate) has increased overall survival in men with hormone-sensitive metastatic prostate cancer.
- Conditions
- Prostate Cancer Metastatic, Radiotherapy Side Effect, Surgery, Urologic Cancer
- Trial name
- IP5-MATTER (NCT04590976)
- Testing
- Semi-Structured Interview Healthcare Professional, Semi-Structured Interview Patients, Think Aloud Interview Patients
- Where
- 35 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- Imperial College London
Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation
Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy
People having radiation therapy to the head and neck often develop painful mouth problems - mouth sores, dry mouth, mouth pain, trouble eating and drinking, and changes in taste.
- Conditions
- Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation, Stomatitis (Oral Mucositis), Xerostomia Due to Radiotherapy
- Trial name
- OSEM (NCT07885033)
- Testing
- ORAL CARE PRODUCT KIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNCANCER LLC
Head and Neck Cancer, Hearing Loss
Maximizing Quality of Life After Cancer Through Rehabilitation
Treatment for head and neck cancer (HNC) often includes cisplatin chemotherapy and radiation. This treatment causes hearing loss and trouble swallowing in 70% of patients.
- Conditions
- Head and Neck Cancer, Hearing Loss, Tinnitus, Dysphagia
- Trial name
- TIMELY REHAB (NCT07622407)
- Testing
- TIMELY REHAB
- Where
- 3 sites in United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Radiodermatitis
Development of a Protective Cream Against Radiodermatitis Caused by Radiotherapy.
The study cream is to be evaluated in a multicenter, randomized, controlled clinical study carried out in 2 hospitals, in the Radiation Oncology service of Valencia to evaluate its radioprotective and radiomitigation effect in…
- Trial name
- RADIOCREMVAL (NCT05886673)
- Testing
- experimental cream, standard of care
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Antonio J. Conde Moreno
Rectal Cancer, Hyperthermia
The Effect of Electro-Hyperthermia in Preoperative Radiotherapy for Locally Advanced Rectal Cancer
Preoperative radiotherapy in locally advanced rectal cancer increases the possibility of complete resection and anal sphincter preservation.
- Trial name
- NCT02546596
- Testing
- Electro-hyperthermia
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Yonsei Hyperthermia Study Group
Proximal Humeral Fractures, Poor Bone Quality
Influence of Local Bone Status on Complications After Surgical Treatment of Proximal Humerus Fractures
The purpose of this study is to evaluate if poor bone quality increases the risk of specific types of treatment complications in patients with proximal humerus fractures treated with open reduction and angle-stable plates…
- Conditions
- Proximal Humeral Fractures, Poor Bone Quality, Treatment Complications
- Trial name
- NCT01143675
- Where
- 10 sites in Austria, China and 2 more
- Volunteers
- 148 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Insufficiency;Cardiac, Cancer
Effect of Physical Training in Patients With Heart Failure Caused by Chemotherapy for Cancer Treatment
New therapies for cancer increased patient survival, but led to the recognition of adverse effects associated with cancer treatment, such as the use of chemotherapy.
- Conditions
- Insufficiency;Cardiac, Cancer, Cardiotoxicity, Heart Failure
- Trial name
- NCT04047901
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Recurrent Head and Neck Cancer
Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) for Recurrent Head and Neck Cancer
Clinical experience of with hyperthermia combined with radiotherapy and chemotherapy for recurrent head and neck cancer is limited.
- Trial name
- NCT02567383
- Testing
- Radiation, Hyperthermia; Thermotron RF-8, Cisplatin
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Thrombocytopenia, Acute Radiation Syndrome
Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation
Patients who undergo total body irradiation (TBI) for stem cell transplantation have prolonged periods of low counts of specific blood cells called platelets. These low platelets counts can cause bleeding and infection.
- Trial name
- NCT00903929
- Testing
- Eltrombopag
- Volunteers
- 19 people
- Sponsor
- Jane Liesveld
Breast Cancer, Radiotherapy
BRAVE-HEART: Breast Cancer Radiotherapy Using Active Breathing Coordinator to aVoid Exposure of HEART
The BRAVE-HEART trial is an ambispective, observational, non-randomized study conducted at Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo (Pavia, Italy).
- Trial name
- BRAVE-HEART (NCT07299812)
- Testing
- Breast Radiotherapy with or without Deep Inspiration Breath Hold (DIBH)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lung Cancer, Lung Function Decreased
Use of Dual Energy Computed Tomography in Thoracic Radiotherapy Planning.
This is a prospective observational study aiming: 1) To quantify lung function using perfusion dual energy computed tomography (DECT) and use this information at the time of treatment planning with preferential sparing of…
- Conditions
- Lung Cancer, Lung Function Decreased, Radiation Pneumonitis
- Trial name
- NCT04863027
- Testing
- Thoracic radiotherapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Radiation Induced Lung Injury, Non Small Cell Lung Cancer
Hyperpolarized Noble Gas MRI Detection of Radiation-Induced Lung Injury
Lung cancer is the leading cause of cancer death in the world; each year lung cancer claims over 20 000 lives in Canada and more than one million lives globally (1).
- Trial name
- NCT03632369
- Testing
- Hyperpolarized xenon-129 MRI
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Radiation Exposure to Operator
Physician Radiation Exposure During Radial Access Cardiac Catheterization Using a RAD Board
Radiation exposure to operator is an occupational hazard of invasive cardiologists. During radial access for diagnostic catheterization, a new radio-dense arm board is advertised to reduce operator radiation exposure.
- Trial name
- NCT02088788
- Testing
- Board, No Board
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Geisinger Clinic
Subacromial Impingement, Rotator Cuff Tears
Reliability of the Subacromial Distance Measurements With Standard Radiographic Imaging
Patients with complaints of shoulder pain or limitation of motion, who admitted to outpatient orthopaedic clinic will be analyzed.
- Trial name
- NCT04759027
- Testing
- subacromial distance measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Göker Utku değer
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