Clinical trials: Radiation Injury
Doxorubicin Induced Cardiomyopathy, Breast Cancer
Prevention Using Exercise Rehabilitation to Offset Cardiac Toxicities Induced Via Chemotherapy
The purpose of this study is to identify patients at risk for future heart failure using novel markers of early cardiac damage and determine if exercise training can improve these emerging markers as well as overall fitness and…
- Conditions
- Doxorubicin Induced Cardiomyopathy, Breast Cancer, Gastric Cancer, Leukemia
- Trial name
- HF-PROACTIVE (NCT02796365)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Henry Ford Health System
Radiation Dermatitis
StrataXRT Versus Aquaphor for the Prevention and Management of Radiation Dermatitis
The aim of this study is to assess the efficacy and safety of StrataXRT® in comparison to standard of care (defined using the Common Terminology Criteria for Adverse Events [CTCAE], version 5.0) by assessing the severity of…
- Trial name
- NCT05553392
- Testing
- StrataXRT, Aquaphor
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stratpharma AG
Radiation Toxicity
Acute Toxicity After Moderate Hypo-fractionated Intensity Modulated Radiotherapy IMRT or Prostate Cancer
External radiation techniques (EBRT) is considered one of the primary therapies for patients of all risk classifications of prostate cacer .
- Trial name
- NCT05265364
- Testing
- IMRT with SIB
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- hanan fawzy
Radiation Injuries
Vortioxetine in the Treatment of Depression Associated With Head and Neck Cancers Undergoing Radiotherapy
The purpose of this study is to evaluate the effects of vortioxetine, once daily (QD), on mood disorders and cognitive dysfunction in patients with head and neck cancers undergoing radiotherapy.
- Trial name
- NCT04818099
- Testing
- Vortioxetine 10 mg
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Cardiac Toxicity
Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00436566
- Testing
- trastuzumab, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation New Onset
Radiotherapy-Associated Atrial Fibrillation
Radiotherapy associated Atrial Fibrillation (RADAF) is an observational study to evaluate onset time and frequency of atrial fibrillation in patients with thoracic malignancies and breast cancer.
- Trial name
- RADAF (NCT05927246)
- Testing
- ECG
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Istanbul University
Anthracyclines-Induced Cardiotoxicity, Cardiotoxicity
Dapagliflozin to Prevent Anthracycline-Induced Cardiotoxicity
Anthracyclines, such as doxorubicin, are effective anticancer agents but may cause dose-dependent cardiac injury, including early changes in left ventricular function and cardiac biomarkers.
- Trial name
- DAPA-AIC (NCT06888505)
- Testing
- Dapagliflozin (Forxiga)
- Where
- Iraq
- Volunteers
- 94 people
- Sponsor
- Hawler Medical University
Cachexia, Fatigue
Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation
This randomized clinical trial studies pulmonary rehabilitation in improving lung function in patients with locally advanced non-small cell lung cancer undergoing chemoradiation.
- Conditions
- Cachexia, Fatigue, Pulmonary Complications, Radiation Toxicity
- Trial name
- NCT02017925
- Testing
- exercise intervention, pulmonary complications management/prevention, quality-of-life assessment
- Sponsor
- Ohio State University Comprehensive Cancer Center
Head and Neck Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Side Effects of High-Dose Intensity-Modulated Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer
RATIONALE: Tests that measure how much saliva is made, hearing, swallowing, voice function, and quality of life may improve the ability to plan treatment for patients with advanced head and neck cancer and may help doctors find…
- Conditions
- Head and Neck Cancer, Long-term Effects Secondary to Cancer Therapy in Adults, Oral Complications of Radiation Therapy, Radiation Toxicity
- Trial name
- NCT00415025
- Testing
- adjuvant therapy, management of therapy complications, quality-of-life assessment
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Disability Physical
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
The chemotherapy medications used for breast cancer treatment are important for achieving a cure, but a potential side effect is that they can cause a decline in functional capacity (reduced exercise tolerance and impaired…
- Conditions
- Breast Cancer, Disability Physical, Heart Failure, Cardiotoxicity
- Trial name
- BE-FITTER (NCT06595147)
- Testing
- Structured Exercise Training, Group-based Yoga and Stretching
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Breast Cancer
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy
The activity of trastuzumab in early-stage, HER2-positive breast cancer, has been demonstrated in many studies, with meta-analyses showing that in combination with a variety of chemotherapy backbones, trastuzumab reduces the risk…
- Trial name
- NCT04928261
- Testing
- Trastuzumab
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer, Cardiac Toxicity
CADY Study ICORG 08-01
RATIONALE: Studying samples of blood in the laboratory from patients with cancer treated with trastuzumab may help doctors learn more about biomarkers related to heart dysfunction.
- Trial name
- NCT00968682
- Testing
- trastuzumab, laboratory biomarker analysis, assessment of therapy complications
- Where
- 14 sites in Ireland
- Volunteers
- 480 people
- Sponsor
- Cancer Trials Ireland
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Radiation Toxicity, Recurrent Breast Cancer
Alkaline Water in Reducing Skin Toxicity in Women With Breast Cancer Undergoing Radiation Therapy
This phase II trial is studying how well alkaline water works in reducing skin toxicity in women with breast cancer undergoing radiation therapy.
- Conditions
- Radiation Toxicity, Recurrent Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT01487954
- Testing
- alkaline water, distilled water, external beam radiation therapy (EBRT)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Case Comprehensive Cancer Center
Radiotherapy Side Effect, Nutrition Related Cancer
Nutrition Education Program for Cancer Patients Receiving Radiotherapy
Using randomized control study, explore the effect of novel nutrition education program on the nutrition status and life quality of cancer patients receiving radiotherapy
- Trial name
- NCT05329688
- Testing
- novel nutrition program
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Medical University WanFang Hospital
Chemotherapeutic Agent Toxicity, Mucositis
Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy
This randomized phase II trial is studying how well selenomethionine (SLM) works in reducing mucositis in patients with locally advanced head and neck cancer who are receiving cisplatin and radiation therapy.
- Conditions
- Chemotherapeutic Agent Toxicity, Mucositis, Radiation Toxicity, Stage III Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT01682031
- Testing
- selenomethionine, cisplatin, radiation therapy
- Where
- 2 sites in United States, New Zealand
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Breast Neoplasms, Heart Injuries
Prospective Assessment of Radiation-induced Heart Injury in Left-sided Breast Cancer
This study is to prospectively investigate the cardiac dose-sparing effect and clinical benefit of deep inspiration breath-hold (DIBH) technique.
- Conditions
- Breast Neoplasms, Heart Injuries, Radiation Toxicity
- Trial name
- NCT03461588
- Testing
- free-breathing, deep inspiratory breath-holding
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Shu lian Wang
Breast Cancer, Radiation Dermatitis
Hydrosorb® Versus Control in the Management of Radio-induced Skin Toxicity: Multicentre Controlled Phase III Randomized Trial
The primary objective consisted of avoiding deterioration and/or restoring the integrity of the skin of patients treated by radiotherapy, right from the first signs of grade 1 or 2 radiation dermatitis.
- Trial name
- HYDROSORB (NCT02839473)
- Testing
- Castalie water spray, Hydrogel Hydrosorb®
- Where
- 2 sites in France
- Volunteers
- 278 people
- Sponsor
- Institut Curie
Radiation Dermatitis
3M Cavilon Advanced Skin Protectant for the Prophylaxis of Radiation Dermatitis
This study observes a liquid skin protectant that is a polymeric-cyanoacrylate solution designed to protect intact or damaged skin due to radiation.
- Trial name
- NCT03546803
- Testing
- 3M™ Cavilon™ Advanced Skin Protectant
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
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