Clinical trials: Radiation Injury
Head and Neck Cancer, Chronic Periodontitis
Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy Side Effect
- Trial name
- HNCs (NCT06529588)
- Testing
- Radiation
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Breast Cancer
Breast Radiotherapy Audio Visual Enhancement for Sparing the Heart
This study investigates the Breathe Well device to test whether it is superior to the existing treatment standard of the Varian Realtime Position Management (RPM) system in assisting patients with deep inspiration breath hold.
- Trial name
- BRAVEHeart (NCT02881203)
- Testing
- Breathe Well, RPM
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- University of Sydney
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly
Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity
- Trial name
- CARTIER (NCT03711110)
- Testing
- Intensive cardiovascular monitoring, No intervention
- Where
- 14 sites in Spain
- Volunteers
- 514 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Cardiotoxicity, Cardiovascular Disease
Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses
The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.
- Conditions
- Cardiotoxicity, Cardiovascular Disease, Neurovascular Disorder, Endothelial Disfunction
- Trial name
- NCT04568161
- Testing
- Physical Characteristics, Muscular Sympathetic Nervous Activity, Cardiac Function
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Artificial Intelligent, Cardiotoxicity
Smart Home Care of Cloud Base ECG on the Cardiotoxicity Prevention on the Cancer Patients.
Thoracic malignancy is the most commonly diagnosed cancer worldwide.1,2 The incidence of thoracic malignancy has decreased in North America, but not in Asia, where it continues to show an increasing trend.
- Conditions
- Artificial Intelligent, Cardiotoxicity, Cardiac Monitor, Cancer Treatment
- Trial name
- AI (NCT04885088)
- Testing
- Wisdom bracelet
- Volunteers
- 400 people
- Sponsor
- Ju-Chi Liu
Radiation Dermatitis
Efficacy of Superoxide Dismutase in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer .
Radiotherapy always results in many complications such as radiation dermatitis,dry mouth, cranial nerve damage, and swallowing function.
- Trial name
- NCT07399990
- Testing
- Saline Spray, SOD spray
- Volunteers
- healthy volunteers welcome
- Sponsor
- West China Hospital
Cancer, Radiotherapy Side Effect
Evaluation of ExacTrac® Imaging Device for Repositioning Quality of Patients Undergoing an External ENT Radiotherapy
Monocentric, category 2 study according to Jardé Law (minimal risks and constraints) of three prospective cohorts: Tumors located at the oropharynx, the oral cavity and the larynx-hypopharynx.
- Trial name
- ST-IGRT-ORL (NCT04670991)
- Testing
- EXATRAC imaging
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Leon Berard
Heart Failure, Cardiotoxicity
Early Detection of Cardiac Toxicity in Childhood Cancer Survivors
To evaluate cardiac MRI and/or serum biomarkers for detecting cardiac cardiac toxicity in children who received anthracycline based chemotherapy (ABC).
- Trial name
- NCT03038997
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Niti Dham
Radiodermatitis, Injury, Radiation
Study Using Spray Skin Protector Versus Conventional Treatment to Prevent Acute Radiodermatitis.
This is a randomized, open-label, single-institution trial designed to evaluate the effectiveness of a spray skin protector in preventing moist desquamation caused by radiotherapy treatment.
- Trial name
- NCT04067310
- Testing
- Spray skin protector, moisturizer Dnativ Revita derm
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Radiation Injury, Brain Tumor
Differentiating Recurrent Brain Tumor Versus Radiation Injury Using MRI
The purpose of this study is to determine if certain MRI imaging sequences (pictures) are more helpful to the physicians in determining if a brain tumor has recurred or if the person has radiation injury following their treatment.
- Trial name
- NCT00760409
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Michigan
Prostate Cancer, Node; Prostate
Pelvic Nodes Ultra-Hypo vs Conventionally Fractionated IMRT With HDR Boost in Prostate Cancer.
Randomized Phase III study, comparing pelvic ultra-hypo fractionated radiotherapy (UHF: 5Gy/fraction) to a standard or moderate hypo-fractionation (1.8-2.15Gy/fraction), both associated to an HDR prostate +/- adjacent seminal…
- Conditions
- Prostate Cancer, Node; Prostate, Radiotherapy Side Effect
- Trial name
- PCS-XI (NCT05820633)
- Testing
- Report and compare changes in a non-inferiority analysis of the International Prostate Symptom Score (I-PSS), Report and compare changes in a non-inferiority analysis of the expanded prostate cancer index composite" (EPIC-26):, Report and compare changes in a non-inferiority analysis of the Sexual Health Inventory for Men (SHIM)
- Where
- 11 sites in Canada
- Volunteers
- 500 people
- Sponsor
- CHU de Quebec-Universite Laval
Lymphoma, Non-Hodgkin, Hodgkin Lymphoma
Subclinical Cardio-toxicities Evaluation With Strain Rate Echocardiography After Chemotherapy and/or Mediastinal Radiotherapy in Patient With Lymphoma
Treatments-related cardiotoxicity is a critical issue in long term lymphoma survivors, particularly at young age, and its early identification is important to prevent clinically relevant cardiac events.
- Conditions
- Lymphoma, Non-Hodgkin, Hodgkin Lymphoma, Toxicity, Cardiac
- Trial name
- Cardiocare (NCT03480087)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
All Type of Cancers With Bony Metastasis
Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients With Painful Bone Metastases
The main goals of deep hyperthermia combined with external beam radiation (EBRT) on bone metastases are the response on pain relief, duration of response and time to achieve complete pain relief.
- Trial name
- NCT01842048
- Testing
- Hyperthermia, External-beam radiotherapy
- Where
- Taiwan
- Volunteers
- 152 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Head and Neck Cancer, Radiotherapy
A New Delineation Approach for Oral Cavity, Oropharynx, Larynx and Hypopharynx in IMRT for Head and Neck Cancer
The investigators tries a new method to delineating the oral cavity, oropharynx, larynx and hypopharynx, and use the head-and-neck region to test whether the method can to create a good IMRT plan, and alleviate the oral radiation…
- Conditions
- Head and Neck Cancer, Radiotherapy, Oropharynx Abnormality, Radiotherapy; Adverse Effect
- Trial name
- NCT05539144
- Testing
- "Oropharyngeal mucosa", oropharynx, oropharynx and "oropharyngeal mucosa"
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Hebei Provincial Hospital of Traditional Chinese Medicine
Immune Checkpoint Inhibitor-associated Myocarditis
ATROPOS: Survival Analysis of ICI-associated Myocarditis
ATROPOS is an international, registry-based observational study of cancer patients with immune checkpoint inhibitor-associated myocarditis (ICI-M).
- Trial name
- ATROPOS (NCT07633587)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Melanoma Stage III or IV
CARDiac Toxicity Following ImmunOtherapy Treatment for Melanoma
People who develop a type of skin cancer known as 'melanoma' are often treated with immunotherapy. The type of immunotherapy used for patients with melanoma is known as Immune Checkpoint Inhibitors (ICI).
- Trial name
- CARD-IO (NCT06605833)
- Testing
- 12-Lead ECG, Transthoracic Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Radiation Dermatitis
LED Photomodulation for Prevention of Post-Radiation Treatment Dermatitis
Radiation dermatitis is a common side-effect of radiation therapy in cancer patients who frequently can experience redness, pain, crusting, and even ulceration of the skin causing suffering and treatment interruption.
- Trial name
- NCT00573365
- Testing
- Gentlewaves Select™ handheld high energy LED array, Radiation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of California, Irvine
Breast Cancer, Radiation Dermatitis
A DB Randomized Study of R1 and R2 WaterJel / AloeVera Jell in Prevention of Radiation Dermatitis in Breast Cancer
The purpose of this study is to evaluate the effects of topical R1 and R2 for prophylaxis of acute radiation dermatitis in patients with breast cancer receiving radiotherapy.
- Conditions
- Breast Cancer, Radiation Dermatitis, Erythema
- Trial name
- NCT01597921
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Water-Jel
Cardiotoxicity, Heart Failure
ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies
Cancer treatments have improved substantially over the past decades, but some effective therapies such as anthracyclines and HER2-targeted agents are associated with severe cardiovascular adverse effects, including heart failure.
- Conditions
- Cardiotoxicity, Heart Failure, Neoplasms, Breast Neoplasms
- Trial name
- ML-CardioTox (NCT07191730)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Breast Cancer, Radiation Dermatitis
Topical Betamethasone Versus Moisturizer in Preventing Radiation Dermatitis in Large-Breasted Patients Treated in the Prone Position
Radiotherapy (RT) is common in the treatment of breast cancer, however, 95% of breast cancer patients are at risk of developing acute and chronic skin toxicities known as radiation dermatitis (RD) which includes symptoms such as…
- Trial name
- NCT06915857
- Testing
- Topical Betamethasone
- Where
- Canada
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
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