Clinical trials: Radiation Injury
Basal Cell Carcinoma, Squamous Cell Carcinoma Skin
Skin Cancer and Hyperthermia and Radiotherapy
The SAHARA trial assesses wether combining ultrahypofractionated accelerated radiotherapy (RT) with hyperthermia is as effective as standard hypofractionated high-dose radiation in treating non-melanoma skin cancer (NMSC).
- Conditions
- Basal Cell Carcinoma, Squamous Cell Carcinoma Skin, Non-melanoma Skin Cancer
- Trial name
- SAHARA (NCT06384053)
- Testing
- Water-filtered infrared-A-hyperthermia (wIRA) hyperthermia combined, Radiotherapy (RT)
- Where
- 4 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Kantonsspital Winterthur KSW
Breast Cancer, Radio Dermatitis
Photobiomodulation in Radiodermatitis in People With Breast Cancer
Most breast cancer patients undergoing radiotherapy develop radiodermatitis, making it one of the most prevalent adverse events during cancer treatment.
- Trial name
- NCT06990165
- Testing
- Photobiomodulation
- Where
- 2 sites in Brazil
- Volunteers
- 148 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Cancer, Immune Defect
Adverse Myocardial and Vascular Side Effects of Immune Checkpoint Inhibitors
Our knowledge on cardiovascular side effects of immune checkpoint inhibitors (ICIs) is restricted to this date to observational retrospective data (mainly case series and pharamcovigilance analysis).
- Conditions
- Cancer, Immune Defect, Cardiovascular Abnormalities
- Trial name
- AMICI (NCT04586894)
- Testing
- Cardiac MRI, Smart cloth, Biobanking
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mucositis, Head and Neck Cancer
Photobiomodulation Home-use Device for Prevention or Treatment of Oral Mucositis in Patients With Head&Neck Malignancies
Patients with head and neck malignancy that are treated with Radiation Therapy [RT] are expected to develop Oral Mucositis (OM) in 60% of cases.
- Conditions
- Mucositis, Head and Neck Cancer, Radiotherapy Side Effect
- Trial name
- PBM&OM-01 (NCT05176834)
- Testing
- B-Cure laser pro
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Erika Carmel ltd
Lymphoma, Radiation Toxicity
Monoclonal Antibody Therapy in Treating Patients With Leukemia
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00019227
- Testing
- pentetic acid calcium, yttrium Y 90 daclizumab
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer, Osteoradionecrosis
Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment.
Objectives High-dose radiotherapy (RT) for head and neck cancer has significant adverse effects on maxillofacial tissues, among which osteoradionecrosis (ORN) is the most severe and potentially life-threatening.
- Conditions
- Head and Neck Cancer, Osteoradionecrosis, Radiotherapy Side Effect, Tooth Avulsion
- Trial name
- NCT04009161
- Testing
- Tooth extraction
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Catholic University of the Sacred Heart
Breast Cancer, Radiation Dermatitis
Hydrosorb® Versus Control in the Management of Radio-induced Skin Toxicity: Multicentre Controlled Phase III Randomized Trial
The primary objective consisted of avoiding deterioration and/or restoring the integrity of the skin of patients treated by radiotherapy, right from the first signs of grade 1 or 2 radiation dermatitis.
- Trial name
- HYDROSORB (NCT02839473)
- Testing
- Castalie water spray, Hydrogel Hydrosorb®
- Where
- 2 sites in France
- Volunteers
- 278 people
- Sponsor
- Institut Curie
Breast Cancer, Neoplasm, Breast
Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)
Breast cancer is the most commonly cancer in women in the overall global population. According to the World Cancer Research Fund International, there were more than 2.25 million new cases of breast cancer in women in 2020.
- Conditions
- Breast Cancer, Neoplasm, Breast, Breast Diseases, Antihypertensive Agents
- Trial name
- NCT05465031
- Testing
- Sacubitril-valsartan
- Where
- 4 sites in Poland
- Volunteers
- 600 people
- Sponsor
- Silesian Centre for Heart Diseases
Breast Cancer, Radiation Dermatitis
A DB Randomized Study of R1 and R2 WaterJel / AloeVera Jell in Prevention of Radiation Dermatitis in Breast Cancer
The purpose of this study is to evaluate the effects of topical R1 and R2 for prophylaxis of acute radiation dermatitis in patients with breast cancer receiving radiotherapy.
- Conditions
- Breast Cancer, Radiation Dermatitis, Erythema
- Trial name
- NCT01597921
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Water-Jel
Dermatitis, Radiation Induced
Efficacy of Pulsed Electromagnetic Field Therapy on Acute Radiodermatitis in Breast Cancer Patients
This study aims to evaluate the impact of PEMF on acute radiodermatitis in breast cancer patient and post mastectomy patients.
- Trial name
- NCT06003764
- Testing
- Pulsed electromagnetic field, traditional skin care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ahram Canadian University
Cognitive/Functional Effects, Delirium
Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
RATIONALE: Donepezil and vitamin E may be able to decrease side effects caused by radiation therapy given to prevent brain metastases in patients with small cell lung cancer.
- Conditions
- Cognitive/Functional Effects, Delirium, Depression, Lung Cancer
- Trial name
- NCT00006349
- Testing
- vitamin E, donepezil hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 9 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Radiation Injury
Longitudinal MR Imaging of Pulmonary Function in Patients Receiving Thoracic Radiation Treatment
The purpose of this study is to determine whether magnetic resonance imaging (MRI) using inhaled hyper polarized xenon-129 (129Xe) gas, and conventional contrast can help visualize impaired lung function and detect changes over…
- Trial name
- NCT02478255
- Testing
- Hyperpolarized 129-Xenon gas, MRI
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Bone Fractures
Ultrasound Assessment of Pediatric Fracture Healing With the PLUS Score
This observational study investigates whether ultrasound can safely and accurately monitor the healing of bone fractures in children, comparing it to standard X-rays.
- Trial name
- USG-FRACTHEAL (NCT07755787)
- Testing
- Point-of-care ultrasound
- Where
- Czechia
- Volunteers
- 1,200 people
- Sponsor
- University Hospital Hradec Kralove
Radiation; Adverse Effect, Pneumonitis
Predictors of Radiation Pneumonitis in Locally Advanced Lung Cancer Treated With Chemoradiation
Lung cancer [LC] is the leading cause of cancer death worldwide. The standard treatment of locally advanced lung cancer unresectable or marginally resectable is combination therapy with radical or preoperative chemoradiation.
- Trial name
- NCT01580579
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Cardiac Disease, Covid19
Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT
The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular…
- Conditions
- Cardiac Disease, Covid19, Cardiotoxicity, Extracellular Space Alteration
- Trial name
- NCT04880317
- Testing
- Cardiac Magnetic Resonance, Additional CT acquisition, Blood tests
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Gynecologic Cancer, Radiotherapy Side Effect
Bone Toxicity Following Pelvic Radiotherapy
A randomised controlled clinical feasibility trial to determine the feasibility and acceptability of a "musculoskeletal health package (MHP)" intervention in women undergoing pelvic radiotherapy for gynaecological malignancies…
- Conditions
- Gynecologic Cancer, Radiotherapy Side Effect, Fracture
- Trial name
- RadBone (NCT04555317)
- Testing
- Musculoskeletal health package
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- The Christie NHS Foundation Trust
Meningioma Atypical, Radiotherapy
Efficacy of Postoperative Radiotherapy for Atypical Meningioma Without Venous Sinus Invasion After Gross-total Resection
Postoperative adjuvant radiotherapy is a key component of comprehensive treatment of meningioma. However, for atypical meningioma after total resection, there is still a huge controversy in patients who need adjuvant radiotherapy…
- Conditions
- Meningioma Atypical, Radiotherapy, Progression-Free Survival, Adverse Effect of Radiation Therapy
- Trial name
- NCT04127760
- Testing
- radiotherapy
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Radiodermatitis, Injury, Radiation
Study Using Spray Skin Protector Versus Conventional Treatment to Prevent Acute Radiodermatitis.
This is a randomized, open-label, single-institution trial designed to evaluate the effectiveness of a spray skin protector in preventing moist desquamation caused by radiotherapy treatment.
- Trial name
- NCT04067310
- Testing
- Spray skin protector, moisturizer Dnativ Revita derm
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Esophageal, Toxicity
MnSOD (Esophageal Protectant) to Prevent Esophagitis During Radiation/Chemotherapy Treatment for Non-Small Cell Lung Cancer (NSCLC)
This is a Phase I-II study evaluating the feasibility, safety, and efficacy of swallowed MnSOD plasmid/liposome (PL) transgene given as protection against radiation-induced esophagitis during concurrent paclitaxel and carboplatin…
- Trial name
- MnSOD (NCT00618917)
- Testing
- Manganese Superoxide Dismutase Plasmid Liposome, carboplatin, paclitaxel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Joel Greenberger
Head and Neck Neoplasms, Radiodermatitis
Topical Boswellia Serrata 2% to Prevent Radiation Dermatitis in Head and Neck Cancer
This study evaluates a topical 2% Boswellia serrata (Indian olibanum) gum-resin cream for the prevention of acute radiation-induced dermatitis in patients with head and neck cancer undergoing radiotherapy.
- Trial name
- NCT07778290
- Testing
- Boswellia serrata 2% topical cream
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Youssef Hashem Hafez
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