Clinical trials: Radiation Injury
Lung Cancer, Interstitial Lung Disease
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease
In this double-blind phase II randomized controlled trial, patients with lung cancer or ≤2 oligometastatic pulmonary lesions and a concomitant diagnosis of ILD who are planned for radical Radiation Therapy (RT) will be randomized…
- Trial name
- RESPIRE-ILD (NCT05986318)
- Testing
- N-Acetyl cysteine, Dexamethasone Oral, Radiation Therapy
- Where
- 4 sites in Canada
- Volunteers
- 98 people
- Sponsor
- David Palma
Radiation-Induced Bladder Injury
Study on Biomarkers of Radiation-Induced Bladder Injury
1. To identify biomarkers of radiation-induced bladder injury; 2. To develop a predictive model for radiation-induced bladder injury.
- Trial name
- NCT07528313
- Volunteers
- 220 people
- Sponsor
- Tongji Hospital
Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy
Circulating Tumor Cell Genome in Peripheral Blood From Hepatocellular Carcinoma Patients Under Radiotherapy
Hepatocellular carcinoma (HCC) is a common cause of cancer mortality in Asia. Most patients were presented with advanced disease.
- Conditions
- Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy, Fatal Outcome
- Trial name
- NCT02066974
- Testing
- hepatoma requiring radiotherapy
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- China Medical University, China
Radiodermatitis; Acute
Use of Topical Olive Oil Cream for Prophylaxis Against Acute Radiodermatitis in Breast Cancer Patients
This study aims to compare the prophylactic effect of topical betamethasone valerate cream and topical olive oil cream in the prevention of acute radiation dermatitis (ARD) in breast cancer patients treated with radiation.
- Trial name
- NCT05285943
- Testing
- Olive oil cream, Betamethasone Valerate Cream, Base Cream
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Cairo University
Back Pain With Radiation, Radiculopathy
Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy 3
This study is a First in Human, prospective, multi-center clinical study intended to collect safety and performance information for the Spinal Stabilization Technologies PerQdisc® Nucleus Replacement System and procedure…
- Conditions
- Back Pain With Radiation, Radiculopathy, Back Pain, Disc Herniation
- Trial name
- LOPAIN3 (NCT05732818)
- Testing
- PerQdisc Nucleus Replacement System
- Where
- 2 sites in Paraguay, Uzbekistan
- Volunteers
- 50 people
- Sponsor
- Spinal Stabilization Technologies
Cancer, Breast, Cardiotoxicity
Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
Although great progress has been made in treating breast cancer, long-term health may be impaired by cancer therapy. For example, some chemotherapy drugs (e.g., anthracyclines) are known to cause declines in heart health.
- Conditions
- Cancer, Breast, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- EXACT2 (NCT03748550)
- Testing
- Aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Nova Scotia Health Authority
Breast Cancer, Radiation Dermatitis
Mepitel Film Breast
Primary Objective To examine the tolerability of Mepitel Film in the prevention of RD patients undergoing whole breast or chest wall RT in the hot and humid weather in Singapore Secondary Objectives To evaluate the incidence of…
- Trial name
- NCT07729423
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- National University Hospital, Singapore
Sunburn, Ultraviolet Radiation Exposure
Test of Interventions to Prevent Skin Cancer Among Danes on Vacation in High UV Index Sunny Destinations
The aim of the study is to test a series of developed effective interventions targeting Danes going on vacation to sunny destinations to decrease sunburn by increasing use of shade, hats, protective clothing, and sunscreen to…
- Conditions
- Sunburn, Ultraviolet Radiation Exposure, Skin Cancer, Malignant Melanoma
- Trial name
- NCT03607578
- Testing
- Other: Control Group - Minimal Intervention, Experimental: Protection Routine 1, Experimental: Protection Routine 2
- Where
- Denmark
- Volunteers
- 1,548 people, healthy volunteers welcome
- Sponsor
- Brian Køster
Radiodermatitis
The Role of Calcipotriol as Radioprotector of Skin
Examining the hypothesis that protecting keratinocytes by calcipotriol can prevent in-vivo cutaneous side effect in patients receiving radiotherapy to the breast.
- Trial name
- NCT00445250
- Testing
- Calcipotriol
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Radiation Dermatitis
Evaluation of the Effect of Nigella Sativa for the Prophylaxis to Radiation Induced Dermatitis in Breast Cancer Patients
Radiation induced dermatitis (RID) is one of the leading adverse events of radiation therapy, and if occurred could alter the course of therapy.
- Trial name
- NCT05693597
- Testing
- Imtenan Oil, Baraka Capsules
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- German University in Cairo
Ischemic Reperfusion Injury, Other Reconstructive Surgery
RIPC During Free Flap With Preoperative Radiotherapy
Remote ischemic preconditioning (RIPC) has shown organ-protective effects in many clinical settings including patients with ischemic heart disease.
- Conditions
- Ischemic Reperfusion Injury, Other Reconstructive Surgery, Radiotherapy
- Trial name
- NCT03535623
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Early Prediction and Warning for Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy
This multicenter clinical study aims to build an intelligent and accurate diagnosis and dynamic prediction and early warning model of cardiotoxicity due to anthracycline-based breast cancer chemotherapy, clarify the value of the…
- Trial name
- NCT06282796
- Testing
- Echocardiography
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- First Hospital of China Medical University
Breast Cancer, Radiotherapy Side Effect
Simultaneous Integrated Boost Technique in Breast Cancer Radiotherapy
Adjuvant radiotherapy after breast conserving surgery has been shown to improve both local control and overall survival. Dose escalation of the tumor bed by addition of a boost after whole breast radiotherapy reduces the risk of…
- Trial name
- NCT04535895
- Testing
- Simultaneous integrated boost
- Where
- Austria
- Sponsor
- Medical University of Graz
Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Radiation
Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients
The overall purpose of this clinical study is to evaluate safety and efficacy of the MuReva Phototherapy System with a light delivery mouthpiece to reduce the severity of oral mucositis (OM) in adult patients with squamous cell…
- Conditions
- Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Radiation, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Head and Neck Cancer
- Trial name
- NCT03972527
- Testing
- Photobiomodulation, Routine Oral Care and Analgesia
- Where
- 12 sites in United States
- Volunteers
- 85 people
- Sponsor
- MuReva Phototherapy Inc.
Head and Neck Cancer, Mucositis Oral
GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer
GM-CSF may protect normal cells from the side effects, such as mucositis, of radiation therapy and may help damaged tissue heal faster after radiation therapy.
- Conditions
- Head and Neck Cancer, Mucositis Oral, Radiation Toxicity, Tongue Cancer
- Trial name
- NCT00293462
- Testing
- sargramostim, oral salt and soda mouthwash
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Marilyn Dodd
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Breast Cancer, Disability Physical
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
The chemotherapy medications used for breast cancer treatment are important for achieving a cure, but a potential side effect is that they can cause a decline in functional capacity (reduced exercise tolerance and impaired…
- Conditions
- Breast Cancer, Disability Physical, Heart Failure, Cardiotoxicity
- Trial name
- BE-FITTER (NCT06595147)
- Testing
- Structured Exercise Training, Group-based Yoga and Stretching
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Heart Diseases
CardioTOxicity Induced by andRogeNICS and Their Antagonists (TORNICS)
Anti-androgenic therapies relying on peripheral and/or central blockade for the treatment of prostate cancer seems to have an impact on the cardio-vascular system.
- Trial name
- TORNICS (NCT03193138)
- Testing
- Hormonal therapies: G03, H01C and L02 in the ATC classification
- Where
- France
- Volunteers
- 3,096 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Breast Cancer, Cardiac Toxicity
Side Effects Involving the Heart in Women With Breast Cancer Receiving Doxorubicin and Trastuzumab
RATIONALE: Studying samples of blood and tissue in the laboratory from women receiving doxorubicin and trastuzumab for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers for…
- Conditions
- Breast Cancer, Cardiac Toxicity, Cardiovascular Complications
- Trial name
- PACE in BC (NCT00875238)
- Testing
- trastuzumab, doxorubicin hydrochloride, polymorphism analysis
- Where
- 4 sites in United States
- Volunteers
- 133 people
- Sponsor
- Vanderbilt University
Cardiac Toxicity, VEGF
Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function
Explore the effects of anti-VEGF targeted drugs on blood pressure and endothelial function in cancer patients.
- Conditions
- Cardiac Toxicity, VEGF, Endothelial Dysfunction
- Trial name
- NCT04962438
- Testing
- Anti-VEGF
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
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