Clinical trials: Radiation Tolerance
Genotoxicity, Cytotoxicity
Assessment of Cytotoxicity, Genotoxicity
Goal: The goal of this observational study is to evaluate the genotoxic and cytotoxic effects of OPG and CBCT on exfoliated buccal mucosal cells Main question: Does CBCT cause greater genotoxic and cytotoxic effects on buccal…
- Conditions
- Genotoxicity, Cytotoxicity, Ionizing Radiation Exposure, Dental X-Ray Exposure
- Trial name
- NCT07330401
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yaxin Wang
Head and Neck Cancer, Radiotherapy
Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer
The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT).
- Trial name
- ROOCT (NCT04610645)
- Testing
- OCT, Dermatoscope
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Cervical Cancer
Individualized Precise Radiotherapy With the Guidance of Radiosensitivity of Locally Advanced Cervical Cancer
Cisplatin-based chemoradiation (CCRT) has been considered as the standard care for patients with locally advanced cervical cancer (LACC). Nevertheless, increasingly more radio-resistant tumors still recur.
- Trial name
- PROGRAMMA (NCT03163979)
- Testing
- 18F-FDG PET/CT and Comet assay guide RapidArc, 18F-FDG PET/CT and Comet assay guide IMRT, RapidArc
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Prostate Cancer
Blood Test to Measure DNA Damage in Blood
To check the radiosensitivity level in individual patients based on their DNA damage level.
- Trial name
- NCT00523471
- Testing
- Blood test
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- AHS Cancer Control Alberta
Renal Transplant Rejection, Tolerance
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor
The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines.
- Conditions
- Renal Transplant Rejection, Tolerance, Kidney Transplant
- Trial name
- NCT03707262
- Testing
- Donor CD34+ and CD3+ cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jeffrey Veale, MD
Bowel Cleanliness
Monitoring of Safety and Tolerance of PICOPREP in Clinical Practice
A Confirmation of Safety, Tolerance and Efficacy of PICOPREP in Clinical Practice.
- Trial name
- NCT01748591
- Where
- 22 sites in Czechia
- Volunteers
- 3,324 people
- Sponsor
- Ferring Pharmaceuticals
HNSCC
Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHN
This study evaluate the regional (neck) nodal control of durvalumab in combination with RT restricted to the primary tumor and the immediately adjacent nodal level (i.e.
- Trial name
- REWRITe (NCT03726775)
- Testing
- Durvalumab
- Where
- 2 sites in France
- Volunteers
- 61 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Breast Neoplasms, Toxicity
Exclusive Intraoperative Radiation Therapy for Breast Cancer
Aim of the study is to evaluate toxicity in breast cancer patients treated with two different doses of Intra Operative Radiotherapy
- Trial name
- NCT01276938
- Testing
- 21 Gy radiation, 18 Gy radiation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Radiosensitivity, Pediatric Cancer
Integrative Molecular Analysis of Individual Radiosensitivity in Pediatric Oncology
Analysis of the individual radiosensitivity in pediatric oncology
- Conditions
- Radiosensitivity, Pediatric Cancer, Radiation Toxicity
- Trial name
- FOCUSO (NCT06033183)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Neolys
Immune Tolerance
Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs
The Stanford Medical Center Program in Multi-Organ Transplantation and the Division of Bone Marrow Transplantation are enrolling patients into a research study to determine if blood stem cells injected after kidney…
- Trial name
- NCT00319657
- Testing
- Hematopoietic cell transplantation, Total lymphoid irradiation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Carcinoma Breast, Radiation Therapy for Primary Breast Cancer
Dosimetric Comparison of Target Volume, Heart and Left Lung in Post Mastectomy Radiotherapy (RT) of Left Sided Breast Cancer by Free Breathing (FB) Versus Deep Inspiration Breath Hold (DIBH) Technique
Breast cancer is a leading cancer among Bangladeshi female. For breast cancer, there are different available treatment options according to the stage of disease. One of the important ones is radiotherapy (RT).
- Conditions
- Carcinoma Breast, Radiation Therapy for Primary Breast Cancer, Radiation Tolerance, Radiation Induced Cardiac Damage
- Trial name
- FB DIBH RT (NCT06746142)
- Testing
- Deep inspiration breath hold radiotherapy, Free breathing radiotherapy
- Where
- 4 sites in Bangladesh
- Volunteers
- 50 people
- Sponsor
- Nishat Tasnim
Advanced Nsclc
Plasma miRNAs Predict Radiosensitivity of Different Fractionation Regimes in Palliative Radiotherapy for Advanced Non-small Cell Lung Cancer：Multicenter Controlled Study.(RadmiR-01)
Lung cancer is a malignant tumor that causes the highest morbidity and mortality, and the main pathological type is non-small cell lung cancer (NSCLC). Most of them present with advanced stage at diagnosis.
- Trial name
- NCT03074175
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Xinqiao Hospital of Chongqing
Solid Tumors With Oligometastatic Spread
5 Fraction Stereotactic Body Radiation Therapy for Oligometastases Regimen, for Extra-Cranial Oligometastases
This is a prospective Phase II study.The purpose of this study is to monitor the side effects and treatment outcomes of delivering higher doses of radiation therapy to the tumour, while limiting the dose of radiation to the…
- Trial name
- 5fr SBRT (NCT01761929)
- Testing
- Radiation: 50Gy in 5 fr (max) to 25 Gy in 5 fr (min). Dose adapted to deliver the highest dose level while respecting normal tissue tolerance
- Where
- Canada
- Volunteers
- 138 people
- Sponsor
- University Health Network, Toronto
Immune Tolerance
Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.
The study will determine whether patients with functioning Human Leukocyte Antigen (HLA) matched kidney transplants for at least one year and who want to discontinue immunosuppressive drugs can be treated with Total Lymphoid…
- Trial name
- NCT03591302
- Testing
- Hematopoietic cell transplantation, Total Lymphoid irradiation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stephan Busque
Radiation Tolerance
Radiation Dosimetry in Teeth
Irradiation of any tissue creates changes in that tissue. Ionizing radiation imparts charges to the tissue as it interacts with tissue components, changing the tissue structure.
- Trial name
- NCT00178347
- Testing
- Exposure to irradiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Prostate Cancer
A Phase I-II Study on Stereotactic Body Radiotherapy in 3 Fractions for Low/Int Risk Prostate Cancer
The present is a phase I-II study testing the safety and the efficacy of extremely hypofractionated radiotherapy for early stage prostate cancer.
- Trial name
- eHYPO (NCT02623647)
- Testing
- stereotactic body radiotherapy SBRT
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Regina Elena Cancer Institute
To Evaluate the Rate of Digestive and Urinary Toxicity
Study Evaluating the Efficacy and the Tolerance of Pelvic-prostatic Hypo-fractionated Radiotherapy Followed by Boost in Patients With Prostate Adenocarcinoma Adverse Intermediate Risk or High Localized Risk
The standard treatment of high-risk prostatic adenocarcinoma is based on pelvic-prostatic external radiotherapy combined with concomitant and adjunctive hormone therapy for a total of 3 years.
- Trial name
- SHORT (NCT03417336)
- Testing
- prostatic boost in brachytherapy with high dose rate (HDR)
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Georges Francois Leclerc
Squamous Cell Carcinoma of the Head and Neck
Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC
The general aim of the study is to evaluate the anti-tumour activity and the tolerance profile of Pembrolizumab + RT in comparison to cetuximab + RT in patients with locally advanced HNSCC and to explore potential correlations…
- Trial name
- PembroRad (NCT02707588)
- Testing
- Pembrolizumab, Cetuximab, Radiotherapy
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Breast Cancer, Cognitive Ability, General
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
RATIONALE: Radiation therapy uses high-energy x rays to kill tumor cells. Radiation therapy may cause skin reactions when patients are exposed to high-energy x rays.
- Conditions
- Breast Cancer, Cognitive Ability, General, Fatigue, Pain
- Trial name
- NCT01407770
- Testing
- DNA analysis, gene expression analysis, enzyme-linked immunosorbent assay
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Wake Forest University Health Sciences
Hepatocellular Carcinoma
Neoadjuvant Hypofractionated Stereotactic Body Radiation Therapy Prior to Surgery for Hepatocellular Carcinoma: a Feasibility Study.
Hepatocellular carcinoma (HCC) is the fifth more common cancer in the world, with high mortality rates, due to the low number of patients who are eligible for therapy with curative intent, like surgical resection.
- Trial name
- KARCHER-1 (NCT04587739)
- Testing
- Surgery with Neoadjuvant stereotactic body radiation therapy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille