Clinical trials: Radiation-Induced Neoplasms
Head and Neck Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004094
- Testing
- carboplatin, fluorouracil, hydroxyurea
- Where
- 4 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Gastrointestinal Cancer
A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer
This is a prospective, interventional, open-label, single-arm, multicenter pilot study evaluating the safety, tolerability and maximum tolerated dose (MTD) of splenic Selective Internal Radiation Therapy (SIRT) using TheraSphere…
- Trial name
- SPLENIC-SIRT (NCT07575854)
- Testing
- TheraSphere
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre Georges Francois Leclerc
Cardiac Toxicity, Malignant Neoplasm
MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum
This trial studies how well magnetic resonance imaging (MRI) works in detecting heart damage in patients with cancer receiving chemotherapy.
- Conditions
- Cardiac Toxicity, Malignant Neoplasm, Breast Cancer
- Trial name
- NCT01719562
- Testing
- Magnetic resonance imaging, Physical Activity, Healthy Living
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Artificial Intelligent, Cardiotoxicity
Smart Home Care of Cloud Base ECG on the Cardiotoxicity Prevention on the Cancer Patients.
Thoracic malignancy is the most commonly diagnosed cancer worldwide.1,2 The incidence of thoracic malignancy has decreased in North America, but not in Asia, where it continues to show an increasing trend.
- Conditions
- Artificial Intelligent, Cardiotoxicity, Cardiac Monitor, Cancer Treatment
- Trial name
- AI (NCT04885088)
- Testing
- Wisdom bracelet
- Volunteers
- 400 people
- Sponsor
- Ju-Chi Liu
Non-small Cell Lung Cancers
Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers
The objective of this prospective phase II protocol is to assess the toxicity and efficacy of pentoxifylline and SABR in the re-treatment of recurrent or new lung cancers
- Trial name
- NCT01871454
- Testing
- stereotactic ablative radiotherapy (SABR), Pentoxifylline
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Louisville
Gastric Cancer
Palliative Radiotherapy for Symptomatic Locally Advanced Gastric Cancer: A Phase II Trial
The hypothesis of this study is that a radiotherapy dose of 36Gy in 12 fractions, which equates to a BED of 48.6Gy, increases the response rates of symptom relief compared to historical controls.
- Trial name
- NCT01341756
- Testing
- Palliative Radiotherapy
- Where
- Singapore
- Volunteers
- 63 people
- Sponsor
- National University Hospital, Singapore
Non Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung
SCION: SABR and Checkpoint Inhibition of NSCLC
The SCION Trial is a clinical trial in patients with early stage non-small cell lung cancer. The purpose of the trial is to investigate whether it is safe and effective to combine standard radiation treatment with a drug called…
- Conditions
- Non Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Non-small Cell Lung Cancer Stage I, Lung Cancer
- Trial name
- SCION (NCT04944173)
- Testing
- Durvalumab, Stereotactic Body Radiotherapy, Circulating Tumor DNA assay
- Where
- 5 sites in Canada
- Sponsor
- University of British Columbia
Radiation Disease
Pelvic Radiation Disease in Childhood Cancer Survivors
This study aims to characterise the impact of radiotherapy on physical symptoms and quality of life in childhood and young adult cancer survivors.
- Trial name
- NCT05533541
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Localized Breast Cancer, Localized Prostate Cancer
Use of Organic Germanium or Placebo for the Prevention of Radiation Induced Fatigue
Participants will be diagnosed with localized prostate or breast cancer and be scheduled to undergo external beam radiation therapy.
- Conditions
- Localized Breast Cancer, Localized Prostate Cancer, Patients Receiving External Beam Radiotherapy
- Trial name
- NCT00651417
- Testing
- Organic Germanium
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Arizona Oncology Services
Breast Cancer, Radio Dermatitis
Autologous Fat Infiltration Versus General Measures as Treatment in Radiodermatitis Induced for Radiotherapy in Breast Cancer Patients
Radiodermatitis is a major problem in oncologic patients, fat grafts previously used for cosmetic procedures have been shown to have regenerative power due to their stem cell content.
- Conditions
- Breast Cancer, Radio Dermatitis, Radiotherapy
- Trial name
- NCT07023796
- Testing
- Autologous fat filtration
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Instituto Mexicano del Seguro Social
Head and Neck Cancer, Radiation-Induced Mucositis
Comparative Study of New Classification and Traditional Classification of Radioactive Oropharyngeal Mucositis
Radiation oropharyngeal mucositis is one of the most painful side effects of radiotherapy in patients with head and neck tumors.
- Trial name
- NCT06307327
- Where
- 4 sites in China
- Volunteers
- 264 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Cardiotoxicity., Anti Her2 Therapy.
Cardiotoxicity in Metastatic Her 2 Positive Patients Treated With Trastuzumab ,Pertuzumab and Taxanes
Approximately 15-25% of all breast cancers are human epidermal growth factor receptor 2 (HER2) positive and it has been well known that HER2 overexpression is associated with more aggressive phenotype and poor prognosis with…
- Conditions
- Cardiotoxicity., Anti Her2 Therapy., Metastatic Breast Cancer
- Trial name
- NCT02101879
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Breast Cancer
Quantifying Radiation-Induced Skin Reactions: Establishing the Foundation for Future Prediction Models
Breast cancer has the highest incidence rate among female cancers, and breast radiotherapy plays an essential role in the treatment of breast cancer.
- Trial name
- NCT06029231
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Accelerated Phase of Disease, Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Older Patients With Chronic Myeloid Leukemia
This clinical trial studies fludarabine phosphate, low-dose total-body irradiation, and peripheral blood stem cell transplant followed by donor lymphocyte infusion in treating older patients with chronic myeloid leukemia.
- Conditions
- Accelerated Phase of Disease, Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Chronic Phase of Disease
- Trial name
- NCT00003145
- Testing
- Fludarabine Phosphate, Total-Body Irradiation, Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 18 people
- Sponsor
- Fred Hutchinson Cancer Center
Pancreatic Neoplasms (Locally Advanced Non-metastatic)
Systemic Therapy and Chemoradiation in Advanced Localised Pancreatic Cancer - 2
This study will evaluate the role of increasing radiotherapy dose and addition of nelfinavir to chemoradiotherapy (CRT) in patients with inoperable pancreatic cancer that has not spread beyond the pancreas.
- Trial name
- SCALOP-2 (NCT02024009)
- Testing
- nab-paclitaxel, 60Gy in 30#, 50.4Gy in 28#
- Where
- 23 sites in United Kingdom
- Volunteers
- 159 people
- Sponsor
- University of Oxford
Lymphoma, Physical Exercise
Effects of Exercise Training in Survivors of Lymphoma
This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and…
- Conditions
- Lymphoma, Physical Exercise, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- LYMfit (NCT06270667)
- Testing
- Aerobic Exercise, Combined Aerobic and Resistance Exercise
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Ototoxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Assessing Ear Damage in Young Cancer Patients Treated With Cisplatin
RATIONALE: New ways to find out about hearing loss after treatment with chemotherapy may improve the ability to plan cancer treatment and may help patients live more comfortably.
- Trial name
- NCT00458887
- Testing
- management of therapy complications
- Where
- 81 sites in United States, Australia and 1 more
- Volunteers
- 301 people
- Sponsor
- Children's Oncology Group
Breast Neoplasms
The Impact of Chronic Mitochondrial Antioxidant Supplementation on CardiovascularToxicity in Breast Cancer Patients
Investigate the protective effect of chronic MitoQ supplementation on cardiovascular toxicity induced by doxorubicin-based adjuvant chemotherapy in breast cancer patients.
- Trial name
- NCT05146843
- Testing
- Mitoquinone
- Volunteers
- 44 people
- Sponsor
- D'Or Institute for Research and Education
Lung Neoplasms
Circulating Cytokines as Predictors of Radiation Induced Pulmonary Toxicity
This study is being conducted by the University of Rochester Cancer Center to determine the levels of cytokines in the blood, and to determine if blood levels of these cytokines are related to the side effects of radiation…
- Trial name
- NCT00178230
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Rochester
Heart Failure, Cardiotoxicity
Early Detection of Cardiac Toxicity in Childhood Cancer Survivors
To evaluate cardiac MRI and/or serum biomarkers for detecting cardiac cardiac toxicity in children who received anthracycline based chemotherapy (ABC).
- Trial name
- NCT03038997
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Niti Dham