Clinical trials: Radiation-Induced Neoplasms
Trismus
Effect Of High Power Laser On Radiotherapy Induced Trismus.
this study Randomized controlled study will be conducted to study (the effect of high power laser therapy on radiotherapy induced trismus in head and neck cancer patients).
- Trial name
- NCT05757024
- Testing
- high power laser therapy
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Non-small Cell Lung Cancer, Esophageal Cancer
Radiation-induced Toxicity of the Heart
Late side effects in radio(chemo)therapy [R(CH)T] pose a critical limitation to patients' overall survival and quality of life. Even though toxicities of the heart are highly relevant for patients with cancer in the thoracic…
- Conditions
- Non-small Cell Lung Cancer, Esophageal Cancer, Breast Cancer Female
- Trial name
- CorTox (NCT06986291)
- Testing
- Imaging and biomarkers
- Where
- Germany
- Volunteers
- 325 people
- Sponsor
- Technische Universität Dresden
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Alopecia; X-Rays
Radiation- Induced Alopecia in Patients Undergoing Radiation Therapy to the Brain
Study will be conducted on patients receiving Whole brain(WB) / Partial Brain(PB) radiotherapy using volumetric modulated arc therapy or intensity modulated radiotherapy at Department of Radiation Oncology, Fortis Memorial…
- Trial name
- NCT03543020
- Testing
- radiation therapy to brain
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Fortis Memorial Research Institute
Radiodermatitis, Breast Neoplasms
Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients
The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
- Conditions
- Radiodermatitis, Breast Neoplasms, Adverse Effect of Radiation Therapy
- Trial name
- NCT02922244
- Testing
- Control, Cucumber cream, Centella cream
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chulabhorn Cancer Center
Radiation-induced Oropharyngeal Mucositis, Swallowing-induced Breakthrough Pain
A Real-world Observational Study of a Mucosal Contouring Method for Radiation-induced Oropharyngeal Mucositis
The performance of the predictive models for the occurrence and severity of oropharyngeal mucositis established using either oral cavity contouring method or mucosa surface contouring method was unsatisfactory in nasopharyngeal…
- Trial name
- NCT06308328
- Where
- 10 sites in China
- Volunteers
- 718 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy
Multicentre Real-life Data Collection Study With CareMin650™ in the Prevention and Treatment of Oral Mucositis and Radio- and/or Chemo-induced Dermatitis
Most patients with cancer or haematological malignancies who receive chemotherapy - broadly defined to include targeted therapies and immunotherapy - and/or external beam radiotherapy may experience serious and disabling adverse…
- Conditions
- Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Oral Mucositis (Ulcerative) Due to Radiation, Dermatitis
- Trial name
- NéoPBM (NCT07054528)
- Where
- France
- Volunteers
- 33,000 people
- Sponsor
- Centre Hospitalier de Valenciennes
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Non-small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer
Abscopal Effect for Metastatic Non-small Cell Lung Cancer.
Patients with Non-small cell lung cancer that had metastatic lesions after been treated with definitive surgery or chemoradiotherapy are being asked to participate in this study. 1.
- Conditions
- Non-small Cell Lung Cancer, Metastatic Non-small Cell Lung Cancer, Radiotherapy, Thymalfasin
- Trial name
- NCT02542930
- Testing
- Radiotherapy, Thymalfasin
- Sponsor
- Zhejiang Provincial People's Hospital
Breast Cancer
Topical Doxepin for Radiation-induced Dermatitis
Radiation dermatitis is one of the most common side effects of radiotherapy approximately occurring in about 95% of patients receiving radiotherapy .
- Trial name
- NCT02447211
- Testing
- Doxepin cream 5%
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Prevention
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients
the purpose of this study is to evaluate the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients
- Trial name
- NCT07256119
- Testing
- Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Dermatitis, Radiation Induced
Efficacy of Pulsed Electromagnetic Field Therapy on Acute Radiodermatitis in Breast Cancer Patients
This study aims to evaluate the impact of PEMF on acute radiodermatitis in breast cancer patient and post mastectomy patients.
- Trial name
- NCT06003764
- Testing
- Pulsed electromagnetic field, traditional skin care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ahram Canadian University
Breast Cancer, Cardiac Toxicity
BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study
Breast radiotherapy RT used until the 1990s was clearly responsible for increased mortality due to long term cardiac complications.
- Trial name
- BACCARAT (NCT02605512)
- Testing
- Subclinical cardiac lesions and biomarkers
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Sophie JACOB
Locally Advanced Pancreatic Cancer
A Study of Locally Advanced Pancreatic Cancer
The primary end point is to evaluate the time to progression after gemcitabine alone versus Gemcitabine-based combination induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced pancreatic cancer.
- Trial name
- NCT01063192
- Testing
- Gemcitabine, Gemcitabine, Oxaliplatin, 5-Fluorouracil, Leucovorin (GOFL)
- Volunteers
- 73 people
- Sponsor
- National Health Research Institutes, Taiwan
Pancreatic Cancer
Induction Cetuximab (IM-C225), Gemcitabine, and Oxaliplatin in Pancreatic Cancer Patients
The primary objective is to evaluate the efficacy of a combination of cetuximab with systemic chemotherapy followed by chemoradiation in locally advanced pancreatic cancer. The primary endpoint is actuarial one-year survival.
- Trial name
- NCT00338039
- Testing
- Cetuximab, Gemcitabine, Oxaliplatin
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Radiation Induced Oral Mucositis
Benzydamine vs Supersaturated Calcium Phosphate Oral Rinses for Radiation Induced Oral Mucositis in Head and Neck Cancer Patients.
The goal of this clinical trial is to compare and correlate salivary macrophage migratory inhibitory factor levels with onset and severity of radiation induced mucositis in head and neck cancer patients by using super saturated…
- Trial name
- NCT07748442
- Testing
- Benzydamine hydrochloride mouthrinse, Super saturated calcium phosphate oral rinses
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Cardiotoxicity
Development of a Pharmacogenomic Panel for Early Detection of Chemotherapy- and Immunotherapy-Induced Cardiotoxicity.
To evaluate the use of a pharmacogenetic and pharmacoepigenetic panel for predicting chemotherapy- and immunotherapy-induced cardiotoxicity in cancer patients.
- Trial name
- NCT07663357
- Where
- 6 sites in Brazil
- Volunteers
- 1,000 people
- Sponsor
- Beneficência Portuguesa de São Paulo
Radiation-Induced Mucositis
The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients
A prospective, randomized, controlled, single-blinded study will be conducted at Clinical Oncology department, Ain Shams University Hospitals, assessing the effect of Alpha Lipoic Acid on the incidence and severity of…
- Trial name
- NCT05023863
- Testing
- Alpha Lipoic Acid 600 MG Oral Tablets, radiation or concurrent chemoradiation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Esophageal Squamous Cell Carcinoma (ESCC)
Induction Chemo-Immunotherapy + Radiotherapy vs Concurrent Chemoradiotherapy for Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma
This is a prospective, randomized, phase II clinical study in patients with unresectable stage III-IVA esophageal squamous cell carcinoma (ESCC). Eligible patients will be randomly assigned in a 1:1 ratio to two treatment groups.
- Trial name
- NCT07559045
- Testing
- Paclitaxel plus Cisplatin or Carboplatin (Induction Chemotherapy), Weekly Paclitaxel plus Cisplatin or Carboplatin (Concurrent Chemotherapy)
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Second Affiliated Hospital of Zunyi Medical University
Cardiac Toxicity, Sarcoma
Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003937
- Testing
- cisplatin, dexrazoxane hydrochloride, doxorubicin hydrochloride
- Where
- 148 sites in United States, Australia and 4 more
- Volunteers
- 253 people
- Sponsor
- Children's Oncology Group