Clinical trials: Radiation-induced Dermatitis
Radiation Dermatitis
Low Level Laser Therapy for Radiation Induced Dermatitis in H & N Squamous Cell Carcinoma
This study will assess the efficacy of LLLT to mitigate and ameliorate the acneiform-rash, radiation dermatitis, and pain, while assessing its impact on patient reported quality of life.
- Trial name
- NCT02384434
- Testing
- THOR Laser System for Low Level Laser Therapy (LLLT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Heath Skinner
Breast Cancer
RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE
Radiation dermatitis is experienced by almost all patients (up to 95%) receiving radiation therapy for cancer. Radiation dermatitis can be a serious condition because, in addition to its direct physical complications and the…
- Trial name
- NCT02142959
- Testing
- Omaveloxolone Lotion 0.5%, Omaveloxolone Lotion 3%, Vehicle Lotion
- Where
- 27 sites in United States
- Volunteers
- 187 people
- Sponsor
- Biogen
DERMATITIS INDUCED BY RADIOTHERAPY IN PATIENTS WHITH BREAST CANCER
Effectiveness of a Cream for Treatment of Dermatitis in Patients Whith Breast Cancer
It is intended to evaluate the effect of a marketed cream (Alantel®) based on natural products at high concentrations for the preventive and curative treatment (early stages) of radiation-induced dermatitis in cancer patients.
- Trial name
- Alantel (NCT04116151)
- Testing
- Cosmetic cream (Alantel (R): aloe vera, chamomile and thime), Usual treatment
- Where
- Spain
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Breast Carcinoma
Testing the Application of Mepitel Film During Radiation Therapy to Reduce Radiation Related Redness and Peeling in Breast Cancer Patients Following Mastectomy
This phase III trial studies how well Mepitel Film works in reducing radiation dermatitis (redness and peeling) in patients with breast cancer during radiation therapy after a mastectomy.
- Trial name
- NCT04989504
- Testing
- Best Practice, Wound Dressing Material, Quality-of-Life Assessment
- Where
- 49 sites in United States
- Volunteers
- 216 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Nasopharangeal Cancer
Topical Chlorhexidine Spray for the Prevention of Acute Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma:
This study investigated the effects of topical chlorhexidine spray on the incidence, severity, and quality of life during radiotherapy in nasopharyngeal carcinoma patients.
- Trial name
- NCT07559877
- Testing
- 2% chlorhexidine, Sterile Water as control
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Breast Cancer, Radiodermatitis
Clinical Trial of The Use of Bolus in Post Mastectomy Irradiation in Breast Cancer
The aim of this study is to evaluate the impact of adding bolus in adjuvant radiotherapy after mastectomy, in relation to the time of treatment interruption and acute effects.
- Trial name
- NCT01925651
- Testing
- No Bolus, Alternate Bolus, Continuous Bolus
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- AC Camargo Cancer Center
Breast Cancer, Radiation Dermatitis
Topical Betamethasone Versus Moisturizer in Preventing Radiation Dermatitis in Large-Breasted Patients Treated in the Prone Position
Radiotherapy (RT) is common in the treatment of breast cancer, however, 95% of breast cancer patients are at risk of developing acute and chronic skin toxicities known as radiation dermatitis (RD) which includes symptoms such as…
- Trial name
- NCT06915857
- Testing
- Topical Betamethasone
- Where
- Canada
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Radiation Dermatitis, Breast Cancer
Effect of a Mushroom Extract-Containing Topical Cosmetic Formulation During Breast Radiotherapy
This study evaluated a mushroom extract-containing topical cosmetic formulation for skin care in women receiving radiotherapy to the breast after breast-conserving surgery.
- Trial name
- NCT07755553
- Testing
- Mushroom extract-containing topical cosmetic formulation, Usual moisturizing cosmetic care
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hifas da Terra S.L.
Dermatitis, Healthy
Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after blister formation.
- Conditions
- Dermatitis, Healthy, Neoplasm, Urticaria
- Trial name
- NCT00001150
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Radiation Dermatitis
Epidermal Skin Grafts to Improve Healing In Radiation Wounds
Patients undergoing radiation for the treatment of malignancies may suffer from side effects to the skin in the form of radiation dermatitis. This can lead to local wound formation with poor healing.
- Trial name
- NCT04560803
- Testing
- CelluTomeTM Epidermal Harvesting System
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Breast Reconstruction, Radiation Dermatitis
Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients
The purpose of this study is to evaluate post-mastectomy breast skin blood supply (perfusion) after radiation therapy, and before and after fat grafting to the breast(s).
- Conditions
- Breast Reconstruction, Radiation Dermatitis, Radiation Fibrosis, Fat Grafting
- Trial name
- NCT04992650
- Testing
- Fat grafting
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Acute Radiation Dermatitis, Head and Neck Cancer (H&N)
Effectiveness of 0.9% Normal Saline Soaking in Managing Acute Radiation Dermatitis
The goal of this clinical trial is to learn if normal saline soaks can reduce the severity of acute radiation dermatitis in patients with sarcomas or head and neck cancer receiving radiotherapy.
- Conditions
- Acute Radiation Dermatitis, Head and Neck Cancer (H&N), Sarcomas
- Trial name
- NCT07553260
- Testing
- Normal Saline Soaks (0.9% Sodium Chloride)
- Where
- Jordan
- Volunteers
- 150 people
- Sponsor
- King Hussein Cancer Center
Radiation Induced Dermatitis
Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer
The standard treatment for early-stage breast cancer is breast-conserving surgery followed by adjuvant radiation therapy to the whole breast.
- Trial name
- NCT01513278
- Testing
- APN201
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Apeiron Biologics
Breast Cancer
Grape Juice and Dermatitis in Breast Cancer
This study aimed to investigate the effect of grape juice on acute radiation dermatitis in breast cancer (BC) patients undergoing radiotherapy (RT).
- Trial name
- NCT04890184
- Testing
- grape juice, control
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Radiation-induced Dermatitis
Study of ST266 Versus Saline in Treating Skin Irritation From Radiation
The objective of this study is to evaluate the safety and efficacy of ST266 in treating radiation burns of the skin in patients undergoing treatments for breast cancer and to compare ST266 treated burns with those treated with…
- Trial name
- NCT01714973
- Testing
- ST266
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Radiodermatitis, Oncology
Jalosome® Soothing Gel Efficacy Grade 2 or 3 Radiodermatitis.
Testing the efficacy of the Jalosome® Soothing gel in 2 or 3 grade radiodermatitis healing in oncological patients. The investigators would like to know also the efficacy of the device on quality of life and pain.
- Conditions
- Radiodermatitis, Oncology, Quality of Life, Pain
- Trial name
- NCT04692389
- Testing
- Jalosome soothing gel
- Where
- Switzerland
- Sponsor
- Welcare Industries SpA
Breast Carcinoma, Head and Neck Carcinoma
StrataXRT for the Prevention and Treatment of Radiation Dermatitis in Breast Cancer or Head and Neck Cancer Patients
This clinical trial studies the effect of StrataXRT in preventing and treating radiation dermatitis in breast cancer or head and neck cancer patients. Radiotherapy is often associated with multiple side effects.
- Conditions
- Breast Carcinoma, Head and Neck Carcinoma, Radiation-Induced Dermatitis
- Trial name
- NCT05073172
- Testing
- Calendula Ointment, Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment, Polyethylene Glycol Hydrogel
- Where
- United States
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer, Breast Cancer Stage
A Study of Oleogel-S10 Gel for the Treatment of Radiation Dermatitis in People With Breast Cancer
The purpose of this study is find out whether Oleogel-S10 is an effective treatment for radiation dermatitis when it is used in combination with a standard wound treatment cream called triamcinolone.
- Conditions
- Breast Cancer, Breast Cancer Stage, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT05190770
- Testing
- Triamcinolone Acetonide, Oleogel-S10
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Cancer, Radiation Dermatitis Acute
Using Silverlon® for Head and Neck Patients With Tracheostomies
The purpose of this study is to determine if prophylactic silver-nylon burn dressing Silverlon® prevents a severe skin reaction under tracheostomy collars.
- Conditions
- Head and Neck Cancer, Radiation Dermatitis Acute, Radiation Treatment
- Trial name
- NCT07856732
- Testing
- Silverlon®
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- State University of New York - Upstate Medical University
Radiation Dermatitis
Retrospective Cohort Study Comparing a Novel Gel Dressing vs SoC in the Treatment of Radiation Dermatitis
Routinely collected data on radiation-induced skin toxicity from 2010 to 2022 will be retrospectively analyzed. Data will be split into two cohorts: patients that received 1) StrataXRT and 2) standard of care.
- Trial name
- NCT05810194
- Testing
- StrataXRT, Calendula, Aquaphor
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Stratpharma AG