Clinical trials: Radiation-induced Fibrosis
Radiation Toxicity, Fibrosis
Pilot Study of the Predictive Value of TREM1 Expression and Activation in Inflammation and Radio-induced Mammary Fibrosis
Breast cancer is the most common cancer in the world. Half of patients with such cancer are treated with radiation therapy. Some patients will develop cutaneous or subcutaneous fibrosis, more or less bothersome.
- Conditions
- Radiation Toxicity, Fibrosis, Breast Cancer
- Trial name
- TREM-1 (NCT04948840)
- Testing
- Blood sampling
- Where
- 3 sites in France, Luxembourg
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse, Luxembourg
Chronic Liver Disease (CLD), Cancer
Chronic Liver Disease and Radiation-induced Second Primary Liver Malignancy
Cancer survivors are at a high risk to develop second primary malignancy (SPM) which constitutes a serious threat for them. Radiotherapy is the cornerstone for the management of many cancers as a locoregional treatment modality.
- Conditions
- Chronic Liver Disease (CLD), Cancer, Liver Fibrosis
- Trial name
- NCT06868394
- Testing
- radiotherapy, No intervention
- Where
- Egypt
- Volunteers
- 20,846 people
- Sponsor
- Suez Canal University
Breast Carcinoma, Fibrosis
Clinical Benefit of Spa Care on Severe Radiation-induced Fibrosis After Postoperative Radiotherapy for Breast Cancer
This study evaluates the dermatological life quality six months after spa cares in patients with severe late toxicity involving the skin and / or soft tissues after postoperative radiotherapy for breast cancer.
- Trial name
- FIBROTHERME (NCT02898376)
- Testing
- skin-oriented spa care, Pentoxifylline, Tocopherol acetate
- Where
- 21 sites in France
- Volunteers
- 142 people
- Sponsor
- Institut de Cancérologie de Lorraine
Radiation Induced Fibrosis to the Head and Neck
Study of Topical Superoxide Dismutase to Treat Radiation Induced Fibrosis
The purpose of this study is to determine if topical superoxide dismutase is an effective treatment of radiation related neck fibrosis, and to determine the quality of life impact from radiation related fibrosis in the head and…
- Trial name
- Sodermix (NCT01771991)
- Testing
- Topical Sodermix Dismutase in the form of Sodermix (SOD)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Sanford Health
Fibrosis
Trental & Vitamin E for Radiation-Induced Fibrosis
This study seeks to determine if a combination of Trental and Vitamin E prevents the development of radiation fibrosis in women treated with radiation for the definitive management of their breast cancer.
- Trial name
- NCT00583700
- Testing
- Pentoxifylline, Vitamin E
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Iowa
Radiation Fibrosis
Pirfenidone in Treating Patients With Fibrosis Caused by Radiation Therapy for Cancer
RATIONALE: Pirfenidone may prevent or lessen fibrosis caused by radiation therapy. PURPOSE: Pilot trial to study the effectiveness of pirfenidone in preventing or lessening fibrosis in patients who have undergone radiation…
- Trial name
- NCT00020631
- Testing
- pirfenidone
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Radiation Pneumonitis, Endostatin
Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis
To verify the efficacy and safety of endostatin in the treatment of SRILI（symptomatic radiation-induced lung injury） and fibrosis.
- Trial name
- NCT03796364
- Testing
- Endostar, standard SRILI treatment
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xinqiao Hospital of Chongqing
Head and Neck Squamous Cell Carcinoma
Multispectral Optoacoustic Tomography in Head and Neck Squamous Cell Cancer
The purpose of this research is to assess the safety and evaluate the potential of the Multispectral Optoacoustic Tomography (MSOT) device to more precisely identify and assess the neck lymph nodes which might be affected in…
- Trial name
- OUSCCMOTORX (NCT06477003)
- Testing
- Multispectral Optoacoustic Tomography, Temperature Measurement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group
Breast Cancer, Radiation Fibrosis
Autologous Fat Grafting in Radiated Soft Tissue Reconstruction
The purpose of this study is to observe the effect of autologous fat grafting on soft tissue reconstruction of the breast following radiation treatment.
- Conditions
- Breast Cancer, Radiation Fibrosis, Fat Grafting
- Trial name
- NCT05890196
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Dyspnea, Lung Cancer
Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer
RATIONALE: Losartan potassium may be effective in treating pulmonary fibrosis caused by radiation therapy in patients with non-small cell lung cancer.
- Conditions
- Dyspnea, Lung Cancer, Pulmonary Complications, Radiation Fibrosis
- Trial name
- NCT00880386
- Testing
- Losartan
- Sponsor
- University of South Florida
Fibrosis
Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen
The pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. Hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of…
- Trial name
- ORT-OXI-2009 (NCT01822405)
- Testing
- pentoxifylline with tocopherol, pentoxifylline+tocopherol + Hyperbaric Oxygen Therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario de Canarias
Fibrosis, Radiation Injuries
Trial of Pentoxifylline in Patients With Functional Disability Caused by Radiation-Induced Advanced Regional Fibrosis
After initial assessment of their condition by specified clinical and laboratory parameters, each of the patients will be treated for 8 weeks at the standard pentoxifylline dose (400 mg po TID).
- Trial name
- NCT00001437
- Testing
- pentoxifylline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Fibrosis
Efficiency Study for Acute Radiation-induced and Chemotherapy-induced Pulmonary Fibrosis With Bevasizumab
Due to the radiosensitivity of the lung, radiation-induced and chemotherapy-induced pneumonitis and pulmonary fibrosis are frequent happened following cancer therapy.
- Trial name
- NCT01917877
- Testing
- Bevacizumab, Dexamethasone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qingdao Central Hospital
Breast Cancer
Prognostic Indicators for Radiation-induced Breast Fibrosis
To study the inflammatory response during and after radiotherapy, especially by measuring the concentration of an enzyme called autotaxin and its product LPA in the blood plasma.
- Trial name
- NCT05031065
- Testing
- Breast Cancer Radiotherapy
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- AHS Cancer Control Alberta
Head and Neck Cancer
Home-Based Photo-Biomodulation for Management of Lymphoedema and Radiation Fibrosis in Patients After Head and Neck Cancer: A Single-Arm Feasibility Trial
This feasibility trial will test the use of photo-biomodulation (PBM) therapy, predominantly self-delivered in the patient's home for 12-weeks, following completion of radiotherapy treatment for head and neck cancer.
- Trial name
- HOME-PBM (NCT07139782)
- Testing
- Riancorp LTU-904 Laser and Handycure® (Medical Quant)
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Radiation-Induced Skin Fibrosis, Head and Neck Squamous Cell Carcinoma
Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis
This phase I, open-label, single-arm, non-randomized clinical trial uses a "3+3" dose-escalation design to evaluate the safety, tolerability, and preliminary efficacy of intradermal delivery of complement factor H (CFH) fragment…
- Trial name
- NCT07567235
- Testing
- CFH Protein-loaded Ice Microneedles (0.5 mg), CFH Protein-loaded Ice Microneedles (1.0 mg), CFH Protein-loaded Ice Microneedles (2.0 mg)
- Where
- China
- Volunteers
- 9 people
- Sponsor
- West China Hospital
Lung Cancer, Radiation Fibrosis
Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
The goal of this study is to investigate the efficacy of [68Ga]CBP8 to detect collagen deposition in radiation induced tissue injury.
- Conditions
- Lung Cancer, Radiation Fibrosis, Radiation Induced Lung Injury, Pancreas Cancer
- Trial name
- NCT04485286
- Testing
- [68Ga]CBP8
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Massachusetts General Hospital
Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
The Evaluation of Manual Therapy for the Prevention of Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
The subjects in this study are the patients with head and neck cancer after completion of the radiotherapy. Radiation-induced fibrosis is inevitable and there is no effective treatment to prevent it.
- Trial name
- NCT04850170
- Testing
- manual therapy, Speech therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital