Clinical trials: Radiation-induced Oral Mucositis
Oral Cavity Cancer, Head and Neck Cancers - Tonsils
Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
As mentioned above, several prior studies have shown the positive effects of oral use of aloe vera juice in managing chemotherapy and radiation-induced oral mucositis and esophagitis.
- Conditions
- Oral Cavity Cancer, Head and Neck Cancers - Tonsils, Esophageal Cancer, Laryngeal Cancer
- Trial name
- NCT05369234
- Testing
- 100% Aloe Vera Juice, Magic Mouthwash, Salt and Baking soda rinse
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Covenant Health Cancer Center
Oral Mucositis (Ulcerative) Due to Radiation
Dexpanthenol Mouthwash to Treat Oral Mucositis
Oral mucositis can be a significant problem for cancer patients. It is typically associated with pain and increased risk of infection and can lead to impaired nutritional status and inadequate hydration.it can be seen in the…
- Trial name
- NCT01318889
- Testing
- Dexpanthenol
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Head and Neck Cancer
Hyperimmune Colostrum and Oral Mucositis
To study the effect of daily intake of hyperimmune colostrum on prevention and treatment of oral mucositis in patients with head and neck cancer undergoing high-dose radiation.
- Trial name
- Mucositis (NCT00699569)
- Testing
- hyperimmune colostrum
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Radiation-induced Oral Mucositis
Hydroxychloroquine Sulfate Tablets for Radiation-induced Oral Mucositis
Evaluate the safety, tolerance and efficacy of hydroxychloroquine sulfate tablets the prevention and treatment of oral mucositis and dysgeusia in patients undergoing radiotherapy
- Trial name
- RIOM (NCT06939582)
- Testing
- Hydroxychloroquine Sulfate Tablets
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Xingchen Peng
Mucositis Oral, Head & Neck Cancer
Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial
Oral mucositis is the inflammation and ulceration of the mucous membranes within the oral cavity, characterized by atrophy, edema, and erythema (1), and it occurs in nearly all patients with advanced head and neck cancer (HNC)…
- Trial name
- NCT07865780
- Testing
- sirolase xtent laser, blue m gel
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Oral Mucositis
Safety and Efficacy of IZN-6N4 Oral Rinse for the Prevention of Oral Mucositis in Patients With Head and Neck Cancer
The purpose of this study is to determine whether an oral rinse composed of botanical extracts is effective in the prevention of severe inflammation of the lining of the oral cavity caused by chemotherapy and radiation therapy…
- Trial name
- NCT01400620
- Testing
- IZN-6N4
- Where
- 10 sites in United States, Israel
- Volunteers
- 110 people
- Sponsor
- Izun Pharma Ltd
Cancer-related Problem/Condition, Head and Neck Cancer
S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat
RATIONALE: Glutamine may be effective in decreasing side effects, such as inflammation of the mouth and throat, caused by radiation therapy. The effectiveness of glutamine for mucositis is not yet known.
- Conditions
- Cancer-related Problem/Condition, Head and Neck Cancer, Pain
- Trial name
- NCT00006994
- Testing
- glutamine, radiation therapy
- Where
- 107 sites in United States, Canada
- Volunteers
- 23 people
- Sponsor
- SWOG Cancer Research Network
Radiation Induced Oral Mucositis
Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancer
The purpose of this clinical study is to evaluate the efficacy of lappaconitine adhesive patch in alleviation radiation induced mucositis pain and the improvements in QOL of patients with nasopharyngeal carcinoma .
- Trial name
- NCT03518489
- Testing
- Lappaconitine Adhesive Patch, standard care
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Fujian Cancer Hospital
Oral Mucositis
A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Oral Mucositis
The initial proposed clinical study will be conducted in adult head and neck cancer subjects. This will be an open-labeled, proof of concept trial to evaluate the efficacy, safety and tolerability of EISO in a form of oral rinse…
- Trial name
- NCT02399228
- Testing
- 0.25% EISO mouth rinse
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Santalis Pharmaceuticals, Inc.
Oral Cancer, Oropharyngeal Cancer
Evaluation of the Photobiomodulation Using LED Lamp for Curative Treatment of Radio-induced Mucositis.
This is a monocentric, prospective, non-comparative phase II study with minimal risks and constraints. The study will aim to assess the curative treatment of radio-induced mucositis by photobiomodulation using LED lamp.
- Trial name
- MuciLight (NCT04251949)
- Testing
- LED photobiomodulation
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Oscar Lambret
Oral Mucositis
Low-energy Laser Therapy for Prevention of Oral Mucositis in Children
Oral mucositis represents a major complication of cytotoxic chemotherapy among cancer in children. Low-power laser therapy (LPLT) has been used to reduce the incidence of oral mucositis in patients who are receiving high-dose…
- Trial name
- NCT01007617
- Testing
- LLLT :low level laser therapy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Head and Neck Malignant Tumors
Lactobacillus Reuteri Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors
To evaluate the efficacy and safety of Lactobacillus reuteri for prevention and treatment of oral mucositis in patients undergoing radiotherapy for malignant head and neck tumors.
- Trial name
- NCT06285591
- Testing
- Lactobacillus reuteri Tablets, Radiotherapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Radiation-Induced Oral Mucositis (RTOM), Head and Neck Cancer
Sancai Fengsui Decoction for RTOM: A Multicenter RCT
How to promote the prognosis and outcome of RTOM, restore oral function, and improve quality of life are key issues for improving the long-term outcomes of head and neck malignant tumor radiotherapy, and are also integral parts…
- Conditions
- Radiation-Induced Oral Mucositis (RTOM), Head and Neck Cancer, Oral Mucositis of RTOG Grade Greater Than 1
- Trial name
- NCT07692997
- Testing
- Sancai Fengsui Decoction
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Mucositis, Nephrotoxicity
Treatment of Radiation and Cisplatin Induced Toxicities with Tempol
A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients.
- Conditions
- Mucositis, Nephrotoxicity, Ototoxicity
- Trial name
- NCT03480971
- Testing
- Tempol
- Where
- 9 sites in United States
- Volunteers
- 120 people
- Sponsor
- Matrix Biomed, Inc.
Radiation Dermatitis, Radiation-induced Oral Mucositis
A Reminder App to Reduce Radiation Dermatitis Rates in Patients with Head-and-Neck Cancer
The goal of this randomized trial is to investigate whether the addition of a reminder app to standard care leads to a reduction of dermatitis and oral mucositis during radio(chemo)therapy for locally advanced squamous cell…
- Trial name
- RAREST-02 (NCT04110977)
- Testing
- mobile application (reminder app)
- Where
- 4 sites in Germany, Spain
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Head and Neck Cancer
Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00352118
- Testing
- filgrastim, pegfilgrastim, cisplatin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Nasopharyngeal Carcinoma, Radiation-induced Oral Mucositis
Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis
The purpose of this study is to determine whether bacterial decolonization of the nares prior to treatment with radiotherapy (RT) for patients with nasopharyngeal carcinoma, can prevent high-grade radiation-induced oral mucositis…
- Conditions
- Nasopharyngeal Carcinoma, Radiation-induced Oral Mucositis, Bacterial Colonization, Quality of Life
- Trial name
- NCT05893810
- Testing
- Mupirocin Ointment
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Oral Mucositis
N Acetylcystene in Treatment of Radiotherapy Induced Oral Mucositis in Oral Cancer Patients
Background: Radiotherapy appears to be one of the most effective therapies in head and neck tumors, however, there are a lot of complications related to it.
- Trial name
- NCT07082621
- Testing
- N-acetylcysteine (NAC) spray, Conventional treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Hams Hamed Abdelrahman
Radiation-Induced Mucositis, Head and Neck Cancer
Benzydamine Oromucosal Solution in Oral Mucositis (BOOM)
The aim of the present study is to collect data on the feasibility of a preventative/therapeutic approach of radiation-induced oral mucositis with benzydamine oromucosal solution (mouthwash) in patients with head and neck cancer.
- Trial name
- BOOM (NCT05055726)
- Testing
- Benzydamine Hydrochloride 0.15% w/v oromucosal solution
- Where
- 10 sites in Hungary, Poland
- Volunteers
- 100 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Radiation Mucositis, Oral Mucositis (Ulcerative) Due to Radiation
Effectiveness of Topical Olive Oil in Prevention and Management of Radiation Induced Oral Mucositis
This research aims to investigate the effectiveness of topical olive oil application both clinically and biochemically as a suitable affordable treatment modality for prevention and management of radiation oral mucositis and its…
- Conditions
- Radiation Mucositis, Oral Mucositis (Ulcerative) Due to Radiation, Radiation-Induced Mucositis
- Trial name
- NCT05322421
- Testing
- Topical Olive Oil, Sodium bicarbonate 5% solution
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Salma Hesham Elhoufi