Clinical trials: Radiotherapy, Adjuvant
Upper Urinary Tract Urothelial Carcinoma
A Clinical Study of the Efficacy and Safety of Disitamab Vedotin in Combination With Radiotherapy for the Adjuvant Treatment of HER2 Overexpressing UTUC Patients With High Risk Factors for Recurrence After Radical Surgery
In this study, 60 patients with HER2 overexpression UTUC with high-risk recurrence factors after radical surgery were proposed to be enrolled, and were assigned to Cohort I (receiving adjuvant therapy group) and Cohort II…
- Trial name
- NCT06210490
- Testing
- Disitamab Vedotin, Radiotherapy, Standard of Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
Trial Evaluating Hypo-fractionated Accelerated Versus Conventional Fractionated Adjuvant RT in Head & Neck Malignancies
Hypo-fractionated radiotherapy reduces the OTT (overall treatment time) which may in turn reduce rapid accelerated repopulation of clonogenic cells during waiting period after surgery.
- Trial name
- Radiotherapy (NCT07573956)
- Testing
- Standard conventionally fractionated PORT, hypo-fractionated PORT
- Where
- India
- Volunteers
- 369 people
- Sponsor
- All India Institute of Medical Sciences
Stage I Prostate Adenocarcinoma AJCC v7, Stage II Prostate Adenocarcinoma AJCC v7
Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery
This randomized phase II/III trial studies docetaxel, antiandrogen therapy, and radiation therapy to see how well it works compared with antiandrogen therapy and radiation therapy alone in treating patients with prostate cancer…
- Conditions
- Stage I Prostate Adenocarcinoma AJCC v7, Stage II Prostate Adenocarcinoma AJCC v7, Stage III Prostate Adenocarcinoma AJCC v7
- Trial name
- NCT03070886
- Testing
- Bicalutamide, Degarelix, Docetaxel
- Where
- 313 sites in United States, Canada and 1 more
- Volunteers
- 612 people
- Sponsor
- NRG Oncology
Pancreatic Cancer
Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00010062
- Testing
- fluorouracil, radiation therapy
- Where
- 30 sites in France, Luxembourg
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Nasopharyngeal Carcinoma
A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients
To investigate the efficacy of adjuvant PFL chemotherapy after radiotherapy vs radiotherapy alone in AJC stage IV nasopharyngeal carcinoma patients.
- Trial name
- NCT00201344
- Testing
- Cisplatin,5-FU,Leucovorin
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Health Research Institutes, Taiwan
Esophageal Cancer
Sutent Following Chemotherapy, Radiation and Surgery For Resectable Esophageal Cancer
The purpose of this study is to see whether or not the combination of cisplatin, irinotecan and radiation, followed by surgery, followed by oral Sutent, is effective and safe for patients with resectable esophageal cancer.
- Trial name
- NCT00400114
- Testing
- Irinotecan, Cisplatin, Radiation
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- University Health Network, Toronto
Locally Advanced Bladder Cancer
Adjuvant Post-radical Cystectomy Treatment for Bladder Cancer
Radical Cystectomy is still the standard treatment in muscle-invasive Bladder cancer. Local recurrence is still the major cause of failure together with distant metastasis.
- Trial name
- NCT01734798
- Testing
- Radiation, gemcitabine and cisplatin, Radiotherapy and Drug
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Cairo University
Breast Cancer, Radiotherapy Side Effect
Weekly Single Fraction Hypofractionated Adjuvant Radiotherapy for Early Stage Breast Cancer
The current study is a prospective phase II study; Eligible patients will receive hypofractionated Irradiation at a total dose of 28.5Gy in 5 once-weekly fractions of 5.7Gy in 5 weeks to the Whole Breast or chest wall with or…
- Trial name
- NCT04580784
- Testing
- Weekly hypofractionation for early breast cancer
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mona Salem
Soft Tissue Sarcoma, Non Metastatic Disease
A Scandinavian Sarcoma Group Protocol for Patients With High-risk Soft Tissue Sarcoma of the Extremities and Trunk Wall
SSG XX is a phase II trial for high-risk soft tissue sarcomas (STS) of the extremities and trunk wall. Prognostic factors (histopathological markers) are used to identify high-risk tumors.
- Trial name
- SSGXX (NCT00790244)
- Testing
- doxorubicin , ifosfamide, doxorubicin, ifosfamide
- Where
- 2 sites in Sweden
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pleural Neoplasms
Phase II Trial of Neo-Adjuvant Pemetrexed Plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma
This study aims to determine how successful the chemotherapy regimen of Pemetrexed plus cisplatin before surgery is at killing all the tumor so that none is left at the time of surgery.
- Trial name
- NCT00087698
- Testing
- pemetrexed, cisplatin
- Where
- 7 sites in United States
- Volunteers
- 77 people
- Sponsor
- Eli Lilly and Company
Stage I Breast Cancer
Partial Breast Radiation to the Lumpectomy Cavity With IMRT in Elderly Women
The standard treatment for women with invasive breast cancer is local excision follow by whole breast radiation. The local recurrence rates are low, side effects are low, and the cosmetic outcome is excellent.
- Trial name
- NCT00337064
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Vermont
Glioblastoma Multiforme
Radiation Therapy and Temozolomide Followed by Temozolomide and Poly ICLC in Treating Patients With Newly Diagnosed GBM
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT00262730
- Testing
- poly ICLC, temozolomide, radiation therapy
- Where
- 9 sites in United States
- Volunteers
- 97 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Cancer, Surgery
Hypofractionation With Simultaneous Integrated Boost for Early Breast Cancer
Simultaneous integrated boost radiotherapy has been investigated in some malignant tumors and appears to be safe and feasible. However, Hypofractionation with simultaneous integrated boost has been investigating in breast cancer.
- Conditions
- Breast Cancer, Surgery, Adjuvant Radiotherapy
- Trial name
- NCT04913532
- Testing
- Hypofractionation with simultaneous integrated boost
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Capital Medical University
Hepatocellular Carcinoma
Combination of SBRT and Immunotherapy in Small Hepatocellular Carcinoma (HSBRT2402)
For inoperable small hepatocellular carcinoma (HCC), stereotactic body radiotherapy (SBRT) is an effective and safe local treatment.
- Trial name
- HSBRT2402 (NCT06313190)
- Testing
- Stereotactic body radiotherapy, Sintilimab
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sun Yat-sen University
Endometrial Cancer, Gastrointestinal Complications
Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for Endometrial Cancer. ICORG 09-06
Post-operative radiotherapy is internationally accepted as standard practice in the management of high-risk endometrial cancer1. Whilst it has no proven impact on overall survival it significantly increases local control.
- Conditions
- Endometrial Cancer, Gastrointestinal Complications, Radiation Toxicity, Urinary Complications
- Trial name
- NCT01164150
- Testing
- 45 Gy/25 fractions
- Where
- 5 sites in Ireland
- Volunteers
- 92 people
- Sponsor
- Cancer Trials Ireland
Cardiotoxicity, Breast Cancer
Strain vs. Left Ventricular Ejection Fraction-based Cardiotoxicity Prevention in Breast Cancer
Comparing preventive effect of myocardial global longitudinal strain-based cardioprotective stragety (angiotensin receptor blocker prophylaxis) with left ventricular ejection fraction-based strategy in breast cancer patients…
- Conditions
- Cardiotoxicity, Breast Cancer, Prevention, Adjuvant
- Trial name
- NCT04429633
- Testing
- Candesartan
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Samsung Medical Center
Glioblastoma
A Study Using Radiation Therapy and Temozolomide to Treat Glioblastoma in Patients Over 70
In this study we propose to determine outcomes of patients age 70 or older treated with radiation over 2 weeks given with temozolomide 75 mg/m2 daily during radiotherapy and as a post radiation treatment of 150 mg/m2 - 200 mg /m2…
- Trial name
- NCT01985087
- Testing
- Hypofractionated radiotherapy, Temozolomide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Louisville
Breast Cancer
Impact of Individualized Radiotherapy Plan Review in Patients Receiving Adjuvant Radiotherapy for Breast Cancer
This study is being conducted to investigate the effect of a more in-depth education plan for patients with breast cancer. Patients will be randomized to receive either the standard education plan during their breast cancer…
- Trial name
- NCT02366806
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, Davis