Clinical trials: Radiotracer
Schizophrenia
A Positron-Emission-Tomography (PET) Study to Measure the Blockade of Dopamine Receptors (D2) in Specific Areas of the Brain in Relation to the Plasma Concentrations of Paliperidone Extended Release (ER) and Oral Risperidone in Schizophrenia Patients and Healthy Controls
The primary objective of this study is to compare the effect of two different antipsychotic compounds which are used in the treatment of schizophrenia (paliperidone ER and risperidone) at their target sites in two specific areas…
- Trial name
- NCT00934635
- Testing
- Paliperidone ER, Oral risperidone, PET Scan
- Where
- Germany
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Janssen-Cilag G.m.b.H
Pulmonary Cancer, Breast Neoplasms
18F-FSPG PET/CT Imaging in Patients With Cancers
This study aims to compare the diagnostic performance of 18F-FDG and 18F-FSPG PET/CT in lung, breast, and abdominal cancers before undergoing therapy.
- Conditions
- Pulmonary Cancer, Breast Neoplasms, Abdominal Cancer
- Trial name
- NCT03144622
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Healthy
Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)
Background: The new drug 18F-PF-06445974 has a little radioactivity. This can be seen by a positron emission tomography (PET) scan. The drug helps researchers see a protein, PDE4B, in the brain.
- Trial name
- NCT03030391
- Testing
- PET, MRI
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Ovarian Cancer, High Grade Ovarian Serous
Using Advanced Imaging Studies to Develop a Profile of High-grade Serous Ovarian Cancer
The researchers are doing this study to find out whether the researchers can combine information provided by PET/MRI scans with information from tests on blood and tissue samples to develop a very detailed description (profile)…
- Trial name
- NCT04454450
- Testing
- PET/MRI, Contrast enhanced CT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy Volunteers, Nicotine Dependence
PET Imaging of Nicotinic Acetylcholine Receptors
Background: Central nicotinic acetylcholine receptors (nAChRs) are the primary target for the action of nicotine. In addition to being involved in tobacco dependence, they are also involved in a variety of brain disorders…
- Conditions
- Healthy Volunteers, Nicotine Dependence, Pharmacokinetics
- Trial name
- NCT01046513
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Prostate Cancer
Dose Optimization and Diagnostic Performance in Prostate Cancer (SPARROW [Staging Prostate Cancer With Advanced RM2 Radiotracer Oncologic Workup])
This is an open-label, nonrandomized, multicenter study conducted in two sequential parts: an initial Phase 2 Dose Optimization Period followed by the Phase 3 Diagnostic Performance Period.
- Trial name
- SPARROW (NCT07831824)
- Testing
- [68Ga]-LNTH-2401
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- Lantheus Medical Imaging
Cancer
IMaging Pilot Study of the αvβ6 Integrin Radiotracer [18F]-A20FMDV2 in PAtients With Solid Cancer Types
A substance called integrin alpha v beta six (αvβ6) is found to be increased in some cancer cells and can play an important role in the development and spread of cancer.
- Trial name
- IMPACT (NCT04285996)
- Testing
- PET Scan
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Queen Mary University of London
HCV
Radiolabel ADME (Absorption, Distribution, Metabolism, and Excretion) Study Of [14C] PF-00868554 In Healthy Adult Male Subjects
This is a phase 1 study to assess the routes of elimination of a single oral dose of [14C] PF-00868554 and to characterize the metabolic profile following single dose administration.
- Trial name
- NCT00823745
- Testing
- [14C]-PF-00868554
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Pfizer
Thrombosis, Atherothrombosis
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis.
- Conditions
- Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI
- Trial name
- iThrombus (NCT03943966)
- Testing
- 18F-GP1 PET CT
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh