Clinical trials: Raman Spectroscopy
Oral Glucose Tolerance Test
Non-invasive Glucose Measurement Using Laser Technology
This study is to evaluate the capability of Raman spectroscopy as a non-invasive method for monitoring concentrations of glucose by illuminating a small spot on the skin, collecting and analyzing the return light.
- Trial name
- (Raman) (NCT03276949)
- Testing
- Blood glucose measurement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabete Mellitus, Medical Device
Non-invasive Glucose Measurement With Raman Technology in Patients With Type 1 and Type 2 Diabetes
The study was established to collect data and reference measurements in order to establish calibration models for the Prototype 0.3
- Trial name
- NCT03781232
- Testing
- Prototype 0.3
- Where
- 2 sites in Germany
- Volunteers
- 47 people
- Sponsor
- RSP Systems A/S
Parkinson Disease, Gait, Festinating
Effect of a Progressive Treadmill Training Protocol for Parkinson's Disease
The primary objective of this single-center, no-profit, longitudinal interventional randomized controlled, single-blind trial is to compare the effects of 2 different treadmill training treatments using C-Mill: the experimental…
- Conditions
- Parkinson Disease, Gait, Festinating, Fall Due to Loss of Equilibrium, Gait, Unsteady
- Trial name
- NCT05902065
- Testing
- AVR Treadmill training with C-Mill, Conventional Treadmill training with C-Mill
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Florence
Diabetes Mellitus
Performance and Safety Evaluation of a Novel Non-invasive Glucose Monitoring Device and Evaluation of the Instructions for Use
The aim of the study is to demonstrate the safety and performance of a novel non-invasive glucose monitoring device, to collect data and reference measurements for establishment of calibration models and to evaluate the…
- Trial name
- NCT04033042
- Testing
- Prototype 0.5
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- RSP Systems A/S
Peri-Implantitis
ATR-FTIR and Raman Spectroscopy of Peri-Implant Crevicular Fluid in Peri-Implantitis
Peri-implantitis is an inflammatory condition affecting the tissues surrounding dental implants and may lead to supporting bone loss. Current diagnosis is mainly based on clinical and radiographic findings.
- Trial name
- NCT07864233
- Testing
- ATR-FTIR and Raman Spectroscopic Analysis of Peri-Implant Crevicular Fluid
- Volunteers
- 100 people
- Sponsor
- Necmettin Erbakan University
Resonance Raman Spectroscopy for Dietary Carotenoid Intake
Carotenoid Response to the Intake of Vegetables and Fruits
The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.
- Trial name
- NCT01403844
- Testing
- Carotenoid Depletion, Carotenoid Repletion, Natural Repletion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Carcinoma, Basal Cell, Intraoperative BCC Detection by Fast Raman Device
Intraoperative Detection of Residual BCC by Fast Raman
The main objective of this research is to develop a new scanning technology called the Fast Raman device, to accurately check the skin removed by the surgeon and detect any residual cancer cells; if found, additional skin can…
- Trial name
- NCT03482622
- Testing
- Fast Raman
- Volunteers
- 600 people
- Sponsor
- University of Nottingham
Femur Head Necrosis
Modifications of the Subchondral Bone in Aseptic Osteonecrosis of the Femoral Head
In this study, the aim is to identify the modifications responsible for aseptic osteonecrosis of the femoral head and its structural evolution by the association of the micro scanner analysis and Raman spectrometry performed on…
- Trial name
- ONTF (NCT02733900)
- Testing
- femoral head removal
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Lille Catholic University
Acute Aortic Dissection
Blood Biomarker Discovery by Raman Spectroscopy in Acute Aortic Dissection
This study intends to collect about 500 cases of blood samples from acute aortic dissection (AAD) and other acute chest pain diseases (eg, AMI, PE, or angina).The investigators tend to detect Raman metabolic profile of blood…
- Trial name
- BBDRSAAD (NCT05206032)
- Testing
- Raman spectroscopy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diagnosis
Label-free Raman Spectroscopy for Discrimination Between Breast Cancer Tumor and Adjacent Tissues After Neoadjuvant Treatment
After neoadjuvant therapy, the primary lesion in breast cancer patients may experience tumor regression, which increases the difficulty of distinguishing between breast cancer and adjacent tissues.
- Trial name
- NCT06394050
- Testing
- Diagnostic Test
- Volunteers
- 150 people
- Sponsor
- RenJi Hospital
Lung Cancer
Analysis of P-Selectin Expression on Platelets of Blood From Lung Cancer Patients
Purpose: Selectins are vascular cell adhesion molecules involved in adhesive interactions of leukocytes and platelets and endothelium within the blood circulation.
- Trial name
- NCT02758678
- Testing
- A single 2 ml heparinised peripheral blood sample
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Science and Technology Park, Center of Innovation Technologies for Human Health
Nephrotic Syndrome
Non-invasive Assessment of Mechano-chemical Properties of Urine Proteins by Hybrid Brillouin-Raman Spectroscopy
The proteinuria is widely recognized as a marker of kidney disease severity, as well as the predictor of renal function decline, cardiovascular outcomes, and all-cause mortality.
- Trial name
- NCT04311684
- Testing
- hybrid Brillouin-Raman spectroscopy
- Where
- Kazakhstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Nazarbayev University
Oral Cancer, Dysplasia
Real-time Molecular Diagnosis of Oral Precancer
The "Real-time molecular diagnosis of oral precancer" or the LIP study is testing a new device for the detection of cancer in the mouth. Oral cancers are serious and devastating illnesses, especially if detected at a late stage.
- Conditions
- Oral Cancer, Dysplasia, Oral Lesions, Oral Pre-cancer
- Trial name
- LIP (NCT07110623)
- Testing
- LIP device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King's College London
Breast Neoplasm
A Prospective Study to Develop and Clinically Validate an in Vitro Diagnostic Medical Device That Uses Blood to Classify Patients at High Risk for Breast Cancer
EXoPERT has developed a liquid biopsy-based in vitro diagnostic medical device that can diagnose cancer through blood. The in vitro diagnostic medical device for this clinical performance trial is a test device that applies a…
- Trial name
- NCT06672302
- Testing
- ExoPred
- Where
- 3 sites in United States, South Korea
- Volunteers
- 330 people
- Sponsor
- EXoPERT
Bone Augmentation, Bone Loss, Alveolar
Evaluation of a Novel Horizontal Ridge Augmentation Technique in Dentistry
This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histomorphometry and Raman spectroscopy.
- Trial name
- NCT05612737
- Testing
- Horizontal bone augmentation
- Where
- Hungary
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Chronic Heart Failure
Prediction of Outcomes in Patients With Chronic Heart Failure Based on Tissue Raman Spectroscopy
Chronic heart failure (CHF) is a syndrome complicating heart disease, the prevalence of which has reached epidemic levels. According to global statistics the most common causes of CHF are coronary heart disease (CHD): 26.5%…
- Trial name
- PROMETHEUS (NCT06393595)
- Testing
- surface enhanced Raman Spectroscopy
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara State Medical University
Inflammatory Bowel Diseases
Artificial Intelligence System Based on Raman Spectroscopy in Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders that can be categorized as ulcerative colitis (UC), Crohn's disease (CD) and indeterminate colitis (IC).
- Trial name
- NCT04888299
- Testing
- Raman spectroscopy (SPECTRA IMDx)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Changi General Hospital
Neurodegenerative Disorders, Parkinson Disease
An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy
The aim of the study is to validate a salivary test that allows for rapid and accurate objective diagnosis in the context of neurodegenerative diseases, a complex of diseases that includes Alzheimer's Dementia, Frontotemporal…
- Conditions
- Neurodegenerative Disorders, Parkinson Disease, Alzheimer Disease, Parkinsonian Disorders
- Trial name
- SANDY (NCT06875739)
- Where
- 4 sites in Italy
- Volunteers
- 310 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Diabetes Mellitus
Study of a Novel Non-invasive Glucose Monitoring Device
This explorative clinical study has been launched to collect spectral Raman data paired with validated glucose reference values in diabetic patients.
- Trial name
- NCT03782441
- Testing
- Prototype 0.5
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- RSP Systems A/S