Clinical trials: Randomized, open to volunteers
Health Communication
Older People's Preventive Care Utilization
Objectives: To empower older people's decision making for taking the recommended vaccines including seasonal influenza vaccines, pneumococcal vaccines, and COVID-19 vaccine (if it is recommended annually).
- Trial name
- NCT05691790
- Testing
- MMA and patient activation intervention scheme, Control Group
- Where
- Hong Kong
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Depressive Disorder, Major Depressive Disorder, Adolescence
Comparing 10 Hz rTMS and iTBS for Adolescent Depression
This trial compares two transcranial magnetic stimulation (TMS) protocols-10 Hz rTMS and intermittent theta burst stimulation (iTBS)-in adolescents with major depressive disorder.
- Trial name
- NCT07873060
- Testing
- 10 Hz Repetitive Transcranial Magnetic, Intermittent Theta Burst Stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Hospital of Shandong University
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
Obesity, Adolescent, Weight Change, Body
Multi-Modal Digital Interventions for Adolescent Weight Management
The goal of this randomized controlled trial is to evaluate the effectiveness of a multi-modal digital intervention, based on the Theory of Planned Behavior (TPB), in promoting healthy weight control behaviors among overweight…
- Conditions
- Obesity, Adolescent, Weight Change, Body, Weight Stigma
- Trial name
- M2DI-AWM (NCT06920862)
- Testing
- Multi-Modal Digital Intervention
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Social Anxiety Disorder
Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders.
- Trial name
- NCT05858346
- Testing
- Transdiagnostic Behavior Therapy, Cognitive Behavioral Therapy for Social Anxiety Disorder
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Ovarian Cancer
Effects of Web-Based Ovarian Cancer Awareness Education on Women's Health Beliefs and Risk-Reducing Behaviors
This randomized controlled study will evaluate the effects of web-based ovarian cancer awareness education on women's awareness of ovarian cancer, health beliefs, and risk-reducing behaviors.
- Trial name
- NCT07882485
- Testing
- Web-Based Ovarian Cancer Awareness Education, General Reproductive Health Information
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ege University
Healthy Adults
The Effects of a Smartphone-Based Acceptance and Commitment Therapy Program on the Mental Health and Quality of Life of Caregivers Working in Long-Term Care Facilities
The aim of this study is to investigate whether a smartphone-based Acceptance and Commitment Therapy (ACT) program can improve the mental health and quality of life of care workers in long-term care facilities.
- Trial name
- NCT07714408
- Testing
- Mobile-based Acceptance and Commitment Therapy (ACT) program, Document-based Acceptance and Commitment Therapy (ACT) Program
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sookmyung Women's University
Refractory Acute Myeloid Leukemia, Early Relapses of Acute Myeloid Leukemia
IMPACT-AML: Randomized Pragmatic Clinical Trial for Relapsed or Refractory AML
The primary objective is to evaluate the efficacy and toxicity of high versus low intensity therapy options in patients with refractory forms and early relapses of acute myeloid leukemia (R/R AML) who are scheduled for allogeneic…
- Trial name
- NCT06418776
- Testing
- Intensive therapy, Low intensity therapy
- Where
- Russia
- Volunteers
- 198 people
- Sponsor
- National Research Center for Hematology, Russia
Stroke, Ischemic
Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban
It remains uncertain whether intravenous tirofiban administered before endovascular thrombectomy could improve disability severity for patients with LVO due to intracranial atherosclerosis.The current study aimed to assess the…
- Trial name
- INSIST-IT2 (NCT07135089)
- Testing
- Intravenous tirofiban before endovascular thrombectomy
- Where
- China
- Volunteers
- 870 people
- Sponsor
- General Hospital of Shenyang Military Region
Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection
Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection, Segmentectomy, Lobectomy
- Trial name
- NCT07626489
- Testing
- Pre-incisional infiltration with ropivacaine plus diprospan
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Delayed Gastric Conduit Emtpying (DGCE), Minimally-invasive Esophagectomy
Balloon Dilation in Patients Undergoing Minimally Invasive Ivor Lewis Esophagectomy and Its Effect on Reducing DGCE
Background: Esophageal carcinoma ranks among the most common and lethal cancers worldwide. Minimally invasive esophagectomy is the standard curative treatment, but postoperative delayed gastric conduit emptying (DGCE) remains a…
- Trial name
- WIDE (NCT07355374)
- Testing
- endoscopic plyoric balloon dilatation performed by experienced gastroenterologists
- Where
- Switzerland
- Volunteers
- 116 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiovascular Diseases (CVD), Depression Anxiety Disorder
Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study)
Psycho-Cardiological Disease studies the complex links between the cardiovascular system and emotions. The two diseases are now the focus of public health organizations, forming a vicious circle of mutual influence.
- Trial name
- NCT07025590
- Testing
- Moderate-intensity continuous movement and Antipsychotics intervention, Antipsychotics intervention(sertraline, escitalopram, fluoxetine, duloxetine, paroxetine, venlafaxine, and fluvoxamine)
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Guangdong Provincial People's Hospital
Overactive Bladder
Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder
OnabotulinumtoxinA is an effective treatment for both idiopathic and neurogenic overactive bladder and was FDA approved for this indication in 2013.
- Trial name
- NCT04020510
- Testing
- onaBoNT-A
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Single Embryo Transfer, Fertilization in Vitro
Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).
Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure.
- Trial name
- TRABLAN (NCT06177613)
- Testing
- Blank culture transfer
- Where
- 7 sites in France, Reunion
- Volunteers
- 1,154 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Not Applicable - Healthy Adult Participants
Study of XmAb412 in Healthy Participants
This Phase 1 Study will evaluate the safety, tolerability, pharmacokinectics and pharmacodynamics of XmAb412 in healthy adult participants
- Trial name
- NCT07713485
- Testing
- XmAb412 Monoclonal Bispecific Antibody
- Where
- 2 sites in Australia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Narcolepsy Type 1, Narcolepsy Type 2
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence
Narcolepsy Type 1 (NT1) and Narcolepsy Type 2 (NT2) are rare conditions that make people feel very sleepy during the day (often referred to as excessive daytime sleepiness [EDS]).
- Trial name
- NCT07598708
- Testing
- cleminorexton
- Where
- 26 sites in United States
- Volunteers
- 222 people
- Sponsor
- Centessa Pharmaceuticals (UK) Limited
Adenoma Detection Rate
Artificial Intelligence-assisted Colonoscopy With or Without Endocuff Vision
Adenoma detection rate (ADR) is considered the single most important quality measure in colonoscopy and a higher ADR can reduce the risk of interval colorectal cancer (CRC).
- Trial name
- NCT05863208
- Testing
- Artificial intelligence, Endocuff vision, High-definition endoscope
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- E-DA Hospital
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Schizophrenia
Effects of Gamified Rehabilitation on Cognitive and Psychosocial Outcomes in Inpatients With Schizophrenia
Schizophrenia is a severe and chronic mental disorder that profoundly impacts patients' psychological, social, and occupational functions. Cognitive impairment is a core symptom that severely limits daily living abilities.
- Trial name
- NCT07557368
- Testing
- Gamified Digital Rehabilitation
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Shanghai Mental Health Center
Parkinson's Disease, Parkinson
Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming
The goal of this clinical trial is to learn whether an objective, data-guided approach to programming deep brain stimulation (DBS) can improve motor outcomes in people with Parkinson's disease who undergo DBS surgery.
- Conditions
- Parkinson's Disease, Parkinson, Parkinsons Disease (PD), Motor Fluctuations
- Trial name
- NCT07369310
- Testing
- Conventional DBS Programming (Monopolar Review), Objective-Guided DBS Programming (Imaging and Local Field Potential-Based)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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