Clinical trials: Randomized, open to volunteers
Suicide, Suicidal Ideation
Effectiveness of the Suicidal Crisis Intervention (SCI)
The main objective of this project is to be able to offer a new, specific evidence-based short-term treatment method, the Suicidal Crisis Intervention (SCI), to reduce suicidality.
- Conditions
- Suicide, Suicidal Ideation, Suicide, Attempted
- Trial name
- RCT SCI (NCT05638204)
- Testing
- Suicidal Crisis Intervention (SCI)
- Where
- 12 sites in Belgium
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Low Back Pain, Low Back Dysfunction
EFFICACY OF ARTIFICIAL INTELLIGENCE DRIVEN PROGRAM VERSUS TRADITIONAL PHYSICAL THERAPY PROGRAM IN PATIENTS WITH LOW BACK DYSFUNCTION
Low back dysfunction is one of the most common musculoskeletal disorders and is associated with pain, disability, and reduced quality of life.
- Trial name
- AI-LBD (NCT07749833)
- Testing
- AI-Driven Rehabilitation Program, Traditional Physical Therapy Program
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Age, Residency
The Effect of Audio-hypnosis on the Academic Performance of Nursing Students.
Exam stress significantly affects the mental health and cognitive functions of nursing students. Audio-hypnosis offers a practical and low-cost intervention.
- Conditions
- Age, Residency, Gender, Stress
- Trial name
- Hypnoacademic (NCT07823647)
- Testing
- Audio hypnosis
- Where
- Morocco
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HASSAN 1st university
Frailty, Frail Older Adults
Cognitive Groove (Brought to You by GERAS DANCE)
The goal of this clinical trial is to determine the effect of a community-based rehabilitation intervention (Cognitive Groove, Brought to you by GERAS DANCE), compared to usual care, on clinical outcomes in community-dwelling…
- Conditions
- Frailty, Frail Older Adults, Frailty in Aging, Frailty Syndrome
- Trial name
- GERAS DANCE (NCT06870149)
- Testing
- Dance Rehabilitation Intervention
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
AIM-IBD: A Microbiome-Targeted Supplement in Mild-to-Moderate Ulcerative Colitis
This Phase 2b randomized, double-blind, placebo-controlled, multicenter trial will evaluate the efficacy and safety of a once-daily oral microbiome-targeted food supplement compared with matching placebo in adults with…
- Conditions
- Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD), Colitis
- Trial name
- AIM-IBD (NCT07619638)
- Testing
- Microbiome-Targeting Nutraceutical
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- ENBIOSIS BIOTECHNOLOGIES
Children Following Robot-assisted Roux-en-Y Hepaticojejunostomy for Choledochal Cysts, Choledochal Cyst
Individualized Drainage Strategy Based on Risk Stratification in Children Undergoing Surgery for Choledochal Cyst: A Prospective Randomized Controlled Trial
Choledochal cyst is a common congenital biliary malformation in children requiring cyst excision with Roux-en-Y hepaticojejunostomy. Traditional practice routinely places abdominal drainage tubes postoperatively.
- Trial name
- NCT07825935
- Testing
- Robot-Assisted Roux-en-Y Hepaticojejunostomy with Drainage Management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xueqiang Yan
Hypertension
Effects and Safety of Clonidine Patch on Young and Middle-aged Smokers With Mild Hypertension
The optimal antihypertensive treatment strategy in young and middle-aged hypertensive adults remains undefined. Clonidine controlled-release patches administered once a week might have the advantage of convenience.
- Trial name
- ECLIPSE (NCT05416840)
- Testing
- Clonidine controlled-release patch, Amlodipine
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Jing Liu
Generalized Myasthenia Gravis
Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)
The purpose of this clinical study is to determine the efficacy and safety of a new oral cladribine formulation in participants with Generalized Myasthenia Gravis (gMG) in comparison to placebo.
- Trial name
- NCT06463587
- Testing
- Cladribine Low Dose, Cladribine High Dose
- Where
- 154 sites in United States, Argentina and 23 more
- Volunteers
- 264 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Mastectomy Patient
Impact of PErioperative Nutrition Intervention on Bioimpedance Phase Angle (IPENIPA) In Breast Cancer Patients
The goal of this clinical trial is to measure the mean difference of phase angle after nutritional intervention in breast cancer patients. The main question it aims to answer is: 1.
- Trial name
- IPENIPA (NCT06890221)
- Testing
- B-Crobes intake complete nutrition
- Where
- Malaysia
- Volunteers
- 114 people
- Sponsor
- University of Malaya
Diabetes Mellitus Type 2 in Obese
Normalized Glucose Levels in Type 2 Diabetes With Carbohydrate or Caloric Restriction
This is a randomized controlled trial to determine whether a low-carbohydrate (LC) diet can lead to normalized blood glucose levels in patients with short duration of type 2 diabetes (T2D).
- Trial name
- CarborCal (NCT05801614)
- Testing
- Low carb diet
- Where
- Sweden
- Volunteers
- 286 people
- Sponsor
- Region Stockholm
Chronic Stroke
ANIMATOR - RehUP BCI Controlled Robotic Therapy vs. an Attention-based Control
ANIMATOR aims to examine how BCI therapy vs. attention based control therapy can be used to treat people in the chronic phase of stroke with moderate to severe upper extremity impairment.
- Trial name
- ANIMATOR (NCT06538506)
- Testing
- RehUp BCI Intervention, Control Therapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD)
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass…
- Conditions
- Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD), Coronary Artery Bypass, Off Pump Coronary Artery Bypass Graft
- Trial name
- OPTICAB (NCT07163858)
- Testing
- passive leg raising for hemodynamic management during open-heart coronary bypass grafting, Use of Noradrenaline only in control group
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Infirmerie Protestante de Lyon
Asthma Chronic, Asthma (Diagnosis)
A Study of Acupuncture for Treating Asthma
Asthma is a common chronic respiratory disease with a low clinical control rate, highlighting the need for novel therapeutic strategies. Recurrent asthma attacks emotional symptoms, such as anxiety and depression, etc.
- Conditions
- Asthma Chronic, Asthma (Diagnosis), Asthma
- Trial name
- NCT07611955
- Testing
- Acupuncture, Usual Care
- Volunteers
- 180 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Children, Pain Management
Effect of Vibration and ShotBlocker on Pain and Fear Levels During Intramuscular Injection in Children in the Emergency Department
This prospective study is planned as a randomized controlled study. The aim of this study is to investigate the effects of vibration and the ShotBlocker method on pain and fear levels in children during intramuscular injection in…
- Conditions
- Children, Pain Management, Vibration, Shotblocker
- Trial name
- NCT07750626
- Testing
- Vibration, Shotblocker
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Locally Advanced/Metastatic/Recurrent ESCC
SYS6010 Versus Chemotherapy in Locally Advanced or Metastatic/Recurrent Esophageal Squamous Cell Carcinoma
This study is a randomized, Controlled, Open-Label, Multicenter Phase Ⅲ Study of SYS6010 vs Investigator's Choice Single-Agent Chemotherapy in Locally Advanced/Metastatic/Recurrent ESCC Patients with Failure of At Least One Line…
- Trial name
- NCT07417735
- Testing
- SYS6010, Investigator's Choice of Chemotherapy (Irinotecan hydrochloride，Paclitaxel，Docetaxel)
- Volunteers
- 436 people
- Sponsor
- CSPC Megalith Biopharmaceutical Co.,Ltd.
Uterine Fibroids (UF)
HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids
The goal of this clinical trial is to learn if High-Intensity Focused Ultrasound (HIFU) is as effective as myomectomy for treating symptomatic uterine fibroids in women aged 18 to 50.
- Trial name
- NCT06692335
- Testing
- High-Intensity Focused Ultrasound (HIFU), myomectomy
- Where
- Hong Kong
- Volunteers
- 112 people
- Sponsor
- Chinese University of Hong Kong
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period.
- Trial name
- NCT05943535
- Testing
- Inhaled Treprostinil, Treprostinil Ultrasonic Nebulizer
- Where
- 165 sites in United States, Argentina and 13 more
- Volunteers
- 698 people
- Sponsor
- United Therapeutics
Non-paroxysmal Atrial Fibrillation
LAA Clipping Versus NOACs to Prevent Stroke in Non-paroxysmal Atrial Fibrillation.
This trial is designed to examine the hypothesis that thoracoscopic LAA clipping is superior to NOACs for stroke, systemic embolism, all-cause mortality, major bleeding events and clinically relevant nonmajor bleeding events in…
- Trial name
- NCT06021808
- Testing
- Thoracoscopic LAA clipping, Novel oral anticoagulant
- Where
- China
- Volunteers
- 290 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hypertension, Left Ventricular Diastolic Dysfunction
Sacubitril/Valsartan Versus Valsartan Alone on Left Atrial Volume Index in Hypertensive Patients
Hypertension is a leading global risk factor for cardiovascular disease and is frequently associated with left atrial and ventricular remodeling, leading to subclinical diastolic dysfunction[cite: 2].
- Conditions
- Hypertension, Left Ventricular Diastolic Dysfunction, Essential (Primary) Hypertension
- Trial name
- NCT07853625
- Testing
- Sacubitril / Valsartan, Valsartan
- Volunteers
- 102 people
- Sponsor
- University of Health Sciences Lahore
Non-small Cell Lung Cancer
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
Researchers are looking for new ways to treat high-risk, localized non-small cell lung cancer (NSCLC) that has been removed with surgery. People with high-risk, localized NSCLC are often treated with surgery.
- Trial name
- INTerpath-014 (NCT07513376)
- Testing
- Intismeran, Pembrolizumab coformulated with berahyaluronidase alfa
- Where
- 124 sites in United States, Australia and 18 more
- Volunteers
- 876 people
- Sponsor
- Merck Sharp & Dohme LLC
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