Clinical trials: Randomized, open to volunteers
Lung Cancer
A Smart Self-Management Support Programme (3S) to Improve Quality of Life in Lung Cancer Patients
Lung cancers patients often experience multiple symptoms (e.g. fatigue, dyspnea, distress, depression, sleep disturbance). The current study attempts to explore the efficacy of the Smart Self-Management Support Programme (3S) in…
- Trial name
- NCT06377124
- Testing
- 3S intervention, GH information
- Where
- 3 sites in Hong Kong
- Volunteers
- 320 people
- Sponsor
- The University of Hong Kong
Phelan-McDermid Syndrome
A Study of NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome
This Phase 3, randomized, double-blind, parallel-group (2-arm), placebo-controlled, multicenter study will evaluate the efficacy and safety of NNZ-2591 compared to placebo in pediatric participants with Phelan- McDermid Syndrome.
- Trial name
- NCT07281079
- Testing
- NNZ-2591
- Where
- 18 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Neuren Pharmaceuticals Limited
Cardiovascular Diseases
Effects of Exergaming to Reduce Sedentary Time in Inactive Patients With Heart Failure
The goal of this to determine the effect of tailored exergaming for inactive patients with heart failure to reduce their sedentary time, improve their daily physical activity, exercise capacity, decrease frailty and improve…
- Trial name
- Heart-eXg (NCT05641662)
- Testing
- Heart Farming
- Where
- 12 sites in Portugal, Slovakia and 2 more
- Volunteers
- 750 people
- Sponsor
- Linkoeping University
Cognitive Abilities, Performance
EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition
Performance-related stress can impair sustained attention, inhibitory control, and memory. This randomized, double-blinded, sham-controlled parallel-arm trial evaluates whether a 30-minute EEG-guided binaural beat audio…
- Conditions
- Cognitive Abilities, Performance, Stress, Cognitive Performance
- Trial name
- NCT07407426
- Testing
- EEG-guided binaural beat audio, Non-binaural audio intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Hearing Aid, Telehealth
Effectiveness and Acceptability of Remote Fine-Tuning of Hearing Aids in Danish Adults
The aim of this clinical trial is to evaluate the effectiveness and user satisfaction of remote fine-tuning of hearing aids compared to traditional face-to-face adjustments.
- Conditions
- Hearing Aid, Telehealth, Hearing Aid Fitting, Effectiveness
- Trial name
- EARFit (NCT06992778)
- Testing
- Remote fine-tuning of hearing aids, Face-to-face fine-tuning of hearing aids
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
NSCLC (Advanced Non-small Cell Lung Cancer), Post Surgical
Radiotherapy Plus Anti-PD-1 Versus Anti-PD-1 Alone in ypTanyN⁺M0 NSCLC
Patients with stage III non-small-cell lung cancer (NSCLC) who receive neoadjuvant chemoimmunotherapy may achieve good response in the primary tumor but still have residual nodal disease after surgery (ypTanyN⁺M0), which is…
- Trial name
- NCT07353476
- Testing
- radiotherapy, PD -1/PD-L1 monoclonal antibody
- Volunteers
- 38 people
- Sponsor
- Shanghai Zhongshan Hospital
Hormone Receptor-Positive and HER2-Negative Advanced Breast Cancer
Comparing Endocrine Therapy Combined With High-Dose Palbociclib and Hydroxychloroquine to Endocrine Therapy Combined With Standard-Dose Palbociclib for Hormone Receptor-Positive and HER2-Negative Advanced Breast Cancer
This is a a phase III, randomized, open-label clinical trial comparing endocrine therapy combined with high-dose palbociclib and hydroxychloroquine to endocrine therapy combined with standard-dose palbociclib for hormone…
- Trial name
- NCT07061717
- Testing
- Palbociclib 125mg qd (3 weeks of treatment followed by 1 week off) + Anastrozole 1mg qd / Letrozole 2.5mg qd / Exemestane 25mg qd, Palbociclib 125mg qd (3 weeks of treatment followed by 1 week off) + Anastrozole 1mg qd / Letrozole 2.5mg qd / Exemestane 25mg qd + Hydroxychloroquine 600mg bid, Palbociclib 200mg qd (3 weeks of treatment followed by 1 week off) + Anastrozole 1mg qd / Letrozole 2.5mg qd / Exemestane 25mg qd + Hydroxychloroquine 600mg bid
- Where
- China
- Volunteers
- 474 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Urinary Incontinence,Stress
Synchronous and Asynchronous Telerehabilitation for Women With Urinary Incontinence
In the adult female Greek population,approximately 27% suffer from urinary incontinence (UI). Nowadays, the conservative, evidence-based and 'gold standard' therapy of UI involves pelvic floor muscles (PFM) training programs…
- Trial name
- NCT06848517
- Testing
- BSATP Group, FtFS Group, Control Group (CG)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Patras
C-Reactive Protein
A Study of Single and Multiple Doses of LY5625573 in Healthy Participants, Including Japanese and Chinese Populations, and Participants With Inflammation (High C-Reactive Protein)
The purpose of this study is to learn if LY5625573 is safe and how well it is tolerated in healthy participants, including Japanese and Chinese participants, and in participants with high levels of a marker for inflammation…
- Trial name
- NCT07867340
- Testing
- LY5625573, Midazolam
- Where
- 3 sites in United States, Singapore
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pain, Vital Signs Monitoring
Aromatherapy and Music on Pain, Vital Signs and Parental Satisfaction in Children Undergoing Peritoneal Dialysis
This study is an experimental randomized controlled study conducted to compare the effect of two different nonpharmacological treatment methods (aromatherapy and music therapy) on pain, vital signs and parental satisfaction to…
- Conditions
- Pain, Vital Signs Monitoring, Parental Satisfaction
- Trial name
- 2024-KAEK-11 (NCT07040410)
- Testing
- Aromatherapy, Music Therapy, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Saglik Bilimleri University
Skin Aging
A Double-Blind, Randomized, Double-Dummy, Active and Placebo-Controlled Clinical Study to Assess the Effect of an Oral Skin Supplement on Skin Health in Healthy Adults
The aim of this study is to investigate the impact of a two skin from within nutritional supplement(s) compared to placebo on skin aging biomarker changes.
- Trial name
- NCT07740824
- Testing
- Active SoftGel Supplement, Active Comparator Powder
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Plantar Fasciitis, Extracorporeal Shock Wave Therapy
ESWT in the Treatment of Plantar Fasciitis
Extracorporeal shock wave therapy (ESWT) has become widely preferred in Turkey and worldwide in recent years for the treatment of musculoskeletal diseases due to its non-invasive nature, ease of application, and low risk of…
- Conditions
- Plantar Fasciitis, Extracorporeal Shock Wave Therapy, Ultrasonography
- Trial name
- NCT07626723
- Testing
- Exercise group, 3 ESWT sessions, 5 ESWT sessions
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Extended Post-operative Oral TXA in Primary THA
The goal of this clinical trial is to learn if extended post-operative oral tranexamic acid (TXA) - a medication that reduces bleeding by slowing the breakdown of blood clots - can improve functional recovery following surgery in…
- Trial name
- NCT07685743
- Testing
- Extended oral tranexamic acid regimen
- Volunteers
- 170 people
- Sponsor
- Oregon Health and Science University
Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma
Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations
This phase III trial compares the effect of adding panitumumab to standard chemotherapy (with nanoliposomal Irinotecan, leucovorin, and 5-fluorouracil [5-FU] or irinotecan, leucovorin, and 5-FU or nab-paclitaxel and gemcitabine)…
- Conditions
- Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8
- Trial name
- NCT06998940
- Testing
- Biospecimen Collection, Computed Tomography, Fluorouracil
- Where
- 274 sites in United States
- Volunteers
- 94 people
- Sponsor
- SWOG Cancer Research Network
Relapsed or Refractory Acute Myeloid Leukemia (AML)
BCL2i CLAG-M in R/R Acute Myeloid Leukemia
This multicenter, open-label phase II study combines CLAG-based therapy with or without venetoclax in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) in order to improve measurable residual disease (MRD)…
- Trial name
- NCT06660368
- Testing
- Cladribine, Cytarabine, Mitoxantrone, G-CSF (CLAG-M) regimen, Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Autism Spectrum Disorder
Evaluating Bone Marrow Cell Transplant for Treating Cerebral Palsy From Brain Hypoxia
This clinical trial aims to evaluate the effectiveness of autologous bone marrow mononuclear cell transfusion in treating cerebral palsy caused by cerebral hypoxia.
- Trial name
- NCT06629324
- Testing
- Autologous Bone Marrow Mononuclear Cell Transfusion, Rehabilitation
- Where
- 2 sites in Vietnam
- Volunteers
- 58 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Masticatory Myofascial Pain Syndrome
MRI Study of OnabotulinumtoxinA (OnabotA) Effect on Jaw Muscle Pain
The goal of this clinical trial is to learn which magnetic resonance images are best able to assess and predict if a participant with masticatory myofascial pain syndrome will benefit from Botox injections, as compared to placebo…
- Trial name
- NCT07878780
- Testing
- Onabotulinumtoxin A
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Weill Medical College of Cornell University
Cough, Anesthesia
Oliceridine vs Sufentanil for Cough During Anesthesia Induction
Sufentanil is the most widely used opioid analgesic for general anaesthesia induction; however, rapid intravenous bolus injection frequently triggers sufentanil-induced cough (SIC).
- Trial name
- NCT07660380
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Shiyou Wei
Type 2 Diabetes Mellitus, Type 2 Diabetes With Chronic Kidney Disease
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background…
- Trial name
- Eluminate-4 (NCT07662135)
- Testing
- Elecoglipron
- Where
- 186 sites in United States, Bulgaria and 14 more
- Volunteers
- 900 people
- Sponsor
- AstraZeneca
Bowel Diseases, Inflammatory, Bowel Surgery
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults
This study is testing whether continuing a medication called dexmedetomidine after surgery can improve quality of recovery for adults undergoing laparoscopic-assisted bowel surgery.
- Conditions
- Bowel Diseases, Inflammatory, Bowel Surgery, Laparoscopic Abdominal Surgeries
- Trial name
- PODEX (NCT07434310)
- Testing
- Dexmedetomidine infusion
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Dr. Naveed Siddiqui
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