Clinical trials: Randomized, open to volunteers
Ankle Fractures, Syndesmotic Injury of the Ankle
Dynamic Fixation for Complex Ankle Fractures With Syndesmotic Diastasis.
This prospective randomized controlled trial aims to evaluate the clinical effectiveness of dynamic fixation in patients with complex ankle fractures associated with syndesmotic diastasis.
- Trial name
- NCT07831265
- Testing
- the dynamic fixation, the screw fixation
- Volunteers
- 100 people
- Sponsor
- Fuzhou University Affiliated Provincial Hospital
Health Adult Subjects
Effects of NR Supplementation on Metabolic Flexibility in Zone 2 Training
Zone 2 training, a low-intensity endurance exercise performed at approximately 66-80% of VO₂max or near the first ventilatory threshold, has gained popularity for improving aerobic capacity, fat metabolism, and mitochondrial…
- Trial name
- NCT07344636
- Testing
- Nicotinamide Riboside (NR)
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZHANG Jiaqi
Nursing Education
Team-Based Learning Integrated Into Clinical Simulation in Nursing Students
This study aims to evaluate whether integrating Team-Based Learning (TBL) into clinical simulation improves learning outcomes in undergraduate nursing students compared with traditional simulation alone.
- Trial name
- TBLab (NCT07444229)
- Testing
- Team-Based Learning Integrated Clinical Simulation, Traditional Clinical Simulation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Inguinal Lymph Nodes Enlarged
The Analgesic Efficacy of Ultrasound Guided Transversalis Fascia Plane Block in Inguinal Lymph Node Dissection
Pain accompanying Inguinal lymph node dissection triggers a complex stress response leading to impairment of pulmonary, immunological and metabolic function.
- Trial name
- NCT07331129
- Testing
- transversalis fascia plane block and surgical sit local anesthetic infiltration
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Type B Aortic Dissection
Real-World Prospective Parallel Controlled Study on Endovascular Therapy for Improving Perfusion and Remodeling of TBAD
There are both common and individual characteristics in patients with type B aortic dissection. Currently, for all subtypes of acute type B dissection, proximal endovascular repair is mostly performed during the subacute phase…
- Trial name
- NCT07022145
- Testing
- Endovascular repair
- Volunteers
- 438 people
- Sponsor
- Shanghai Zhongshan Hospital
Partial Edentulism, Dental Implant
Immediate vs Conventional Loading With Different Crown Materials on Immediately Placed Single Implants
This randomized controlled trial compares immediate and conventional loading of single implants placed immediately into fresh extraction sockets in the upper front and premolar region.
- Conditions
- Partial Edentulism, Dental Implant, Tooth Loss in the Esthetic Zone Requiring Immediate Implant Placement
- Trial name
- NCT07882095
- Testing
- Conventional loading, Monolithic zirconia crown, Permanent 3D-printed PMMA crown
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Healthy Infants
Efficacy of a Dietary Supplement in Infants
This is a double-blind, randomized, placebo-controlled nutritional study of healthy term infants. The primary objective of the trial is to demonstrate a favorable change in fecal microbiome composition in infants receiving a…
- Trial name
- NCT07341477
- Testing
- Experimental Group, Control Group (CG)
- Where
- 2 sites in Philippines
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Sepsis
Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis
This clinical trial aims to determine if the type of intravenous fluid used for initial resuscitation affects the short-term outcomes of adult patients with sepsis who are treated in the emergency department.
- Trial name
- NCT07240701
- Testing
- Ringer's Lactate, Normal Saline (0.9% Sodium Chloride)
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Egemen Yildiz
Depression, Anxiety
Preliminary Testing and Development of a Short Digital Intervention for Patients on Waiting Lists for Psychological Treatment
The goal of this randomized pilot feasibility trial is to assess the feasibility and further develop a single-session digital mental health intervention for patients on waiting lists for psychological treatment.
- Trial name
- NCT07499219
- Testing
- Digital therapy program (short), Digital therapy program (long), Mental health advice
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Anxiety Disorders, Panic Disorder
Efficacy of Expectancy Focused Exposure Therapy for Anxiety Disorders
This clinical trial evaluates whether an optimized exposure-based treatment improves long-term outcomes for adults with anxiety disorders.
- Conditions
- Anxiety Disorders, Panic Disorder, Social Anxiety Disorder (SAD), Generalised Anxiety Disorder
- Trial name
- EFE-AD (NCT07753330)
- Testing
- Expectancy Focused Exposure, Anxiety Focused Exposure
- Where
- Chile
- Volunteers
- 203 people
- Sponsor
- University of Chile
Thymic Epithelial Tumor
RATT Vs. VATT for Early-stage TETs
This study is a prospective, multicenter, phase II randomized controlled trial. We plan to screen 100 eligible thymoma patients for robotic-assisted thoracoscopic thymectomy (RATT) or video-assisted thoracoscopic thymectomy…
- Trial name
- NCT06654830
- Testing
- RATT, VATT
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Hemorrhoidal Bleeding, Hemorrhoids, Internal
Rectal Arterial Embolization vs Band Ligation for the Treatment of Internal hemOrrhoidS
The purpose of this clinical trial is to compare two standard of care non-surgical treatments for hemorrhoidal bleeding: hemorrhoidal artery embolization (HAE) versus rubber band ligation (RBL).
- Conditions
- Hemorrhoidal Bleeding, Hemorrhoids, Internal, HAE, RBL
- Trial name
- STRATOS (NCT07559630)
- Testing
- Hemorrhoidal Artery Embolization, Rubber Band Ligation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Jessica K. Stewart, MD
Epilepsy, Healthy Volunteer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
This is a dose escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of SIF001, a monoclonal antibody with the potential to treat epilespy
- Trial name
- NCT07051629
- Testing
- SIF001
- Where
- 10 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Suninflam Inc
Pudendal Neuralgia
Conventional Versus High-Voltage Long-Duration Pulsed Radiofrequency of the Pudendal Nerve
This study is a single-center, prospective, randomized controlled trial evaluating two types of pulsed radiofrequency (PRF) treatment for patients with pudendal neuralgia.
- Trial name
- NCT07356102
- Testing
- Intervention Type * Select the type of intervention. Procedure / Surgery Intervention Name * Enter a brief, descriptive name for the intervention. Use a non-proprietary (generic) name, if available, High-Voltage Long-Duration Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ankara City Hospital Bilkent
Surgery
AI-driven Clinical Decision Support for Perioperative Blood Orders
20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion.
- Trial name
- SPATH (NCT07223853)
- Testing
- S-PATH clinical decision support system, Usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Respiratory Syncytial Virus (RSV), Human Metapneuomovirus (hMPV)
A Study to Investigate Safety, Reactogenicity, and Immunogenicity of mRNA-1365 (Profile 2) in Older Healthy Adults
The main objective of this trial is to evaluate the safety, reactogenicity, and immunogenicity of study interventions across intervention groups
- Trial name
- NCT07764237
- Testing
- mRNA-1365 (Profile 2), mRNA-1345 (Profile 1), mRNA-1345 (Profile 3)
- Where
- 10 sites in Canada, United Kingdom
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Head and Neck Cancer, Radiation-Induced Mucositis
A Randomized Controlled Study on the Improvement of Medical Experience for Patients With Radiation-induced Oropharyngeal Mucositis Based on the RIS System of the Internet of Things
This study is a researcher-initiated, multi-center, prospective, two-arm interventional randomized controlled study across the country.
- Trial name
- NCT07126457
- Testing
- RIS system
- Where
- 4 sites in China
- Volunteers
- 110 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatitis B
A Study to Compare Blood Levels of Bepirovirsen and Safety Using Different Methods of Injecting in Healthy Adult Participants
This is an open-label study being done to compare two different methods of study medicine bepirovirsen is given in healthy adults.
- Trial name
- NCT07905157
- Testing
- Bepirovirsen
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Esports Players
Can Different Exercise Modalities Improve Esports Performance?
This study aims to investigate the long-term effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on esports performance through a 12-week three-arm randomized controlled trial, and…
- Trial name
- NCT07150312
- Testing
- HIIT, MICT
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ma Ruisi
PTSD - Post Traumatic Stress Disorder, Cardiac Arrest (CA)
Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)
The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest.
- Trial name
- NCT07410481
- Testing
- Acceptance and Mindfulness Based Exposure Therapy, Present-Centered Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
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