Clinical trials: Randomized, open to volunteers
Labour Analgesia
Effect of Epidural Needle Injection on Catheter Placement Success During Painless Labour
Epidural analgesia is the gold standard for painless labour, but successful catheter placement can be technically challenging due to anatomical and physiological changes in pregnancy.
- Trial name
- NCT07327918
- Testing
- Injection Group, Control group
- Where
- Egypt
- Volunteers
- 216 people
- Sponsor
- Al-Azhar University
Healthy Volunteers
Comparison of HBW-3220 Capsule Formulations and the Effect of Food in Healthy Participants
This Phase 1 study will evaluate a new formulation of HBW-3220 capsules in healthy adults. It will compare how much and how quickly HBW-3220 enters the bloodstream after a single 120 mg dose of the new formulation versus the…
- Trial name
- NCT07799597
- Testing
- HBW-3220 Old Formulation Under Fasting Conditions, HBW-3220 New Formulation Under Fasting Conditions, HBW-3220 New Formulation Under Fed Conditions
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Bladder Cancer (BC)
Local Radiotherapy for Urinary Bladder Cancer in Patients Not Eligible for Curative Treatment
The goal of this clinical trial is to improve the quality of life and prolong survival in bladder cancer patients unfit for curative treatment.
- Trial name
- LORUP (NCT07524426)
- Testing
- Local hypo fractionated adaptive radiotherapy and Standard of Care, Standard of Care (Investigator Choice)
- Where
- Sweden
- Volunteers
- 248 people
- Sponsor
- Umeå University
Parkinson's Disease Psychosis
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
Patients with Parkinson's disease (PD) sometimes experience symptoms affecting their movement, such as slowness, tremor, stiffness, and balance or walking problems.
- Trial name
- C-SAPP (NCT04373317)
- Testing
- Pimavanserin, Quetiapine
- Where
- 24 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
SCA7
Riluzole in Patients With Spinocerebellar Ataxia Type 7
Spinocerebellar ataxia type 7 (SCA7) belongs to the dominant forms of inherited cerebellar ataxias (CA), being one of the rarest form.
- Trial name
- NCT03660917
- Testing
- Riluzole
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- S. Andrea Hospital
Relapsed / Refractory Multiple Myeloma
Comparing Lower Versus Standard Doses of Belantamab Mafodotin With Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma.
This study is testing whether a lower dose of belantamab mafodotin used together with pomalidomide and dexamethasone can provide similar effectiveness with fewer side effects compared with the standard dose in patients with…
- Trial name
- REBEL (NCT07748689)
- Testing
- Belantamab Mafodotin, Pomalidomide, Dexamethasone
- Volunteers
- 228 people
- Sponsor
- Polish Myeloma Consortium
HIV-1 Infection, Acquired Immunodeficiency Syndrome
Qiling Yiqi Tablets Plus Antiretroviral Therapy for HIV Immune Non-responders With Lung-Spleen Qi Deficiency
This pragmatic randomized controlled trial evaluates whether Qiling Yiqi Tablets combined with antiretroviral therapy (ART) improves immune reconstitution in people with HIV who meet criteria for immune reconstitution failure and…
- Conditions
- HIV-1 Infection, Acquired Immunodeficiency Syndrome, Immune Reconstitution Failure, Immunological Non-responder
- Trial name
- QLYQ-INR-pRCT (NCT07698574)
- Testing
- Qiling Yiqi Tablets plus ART, Antiretroviral Therapy (ART)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing University of Chinese Medicine
Thymoma Malignant Recurrent
Randomized, Multicenter, Phase III Trial to Assess Conformal Post-operative Radiotherapy vs. Surveillance After Complete Resection of Stage II/III Thymoma (RADIO-RYTHMIC-01)
The primary objective of the study : to compare the Recurrence-Free survival (RFS) between arms. RFS is defined as time from randomisation to the first recurrence (either local-regional or distant) or death of any cause.
- Trial name
- RADIO-RYTHMIC (NCT04731610)
- Testing
- Radiotherapy, Surveillance after resection
- Where
- 21 sites in France
- Volunteers
- 314 people
- Sponsor
- Institut Curie
Metabolic Health
Radicle HealthTM VIP: A Study Assessing the Impact of Health and Wellness Products on Metabolic Health and Related Health Outcomes
Radicle HealthTM VIP: A randomized, double-blind, placebo-controlled direct-to-consumer study assessing the impact of health and wellness products on metabolic health and related health outcomes.
- Trial name
- NCT07819110
- Testing
- Active Metabolic Product 1
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Septic Cardiomyopathy, Septic Shock
The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis
This study focuses on improving heart function in patients with life-threatening blood infections (septic shock). When the body fights severe infections, the heart sometimes struggles to pump blood effectively, which can lead to…
- Trial name
- SHIELD Trail (NCT06898723)
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 440 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Colorectal Carcinoma, Oligometastases
SCRT-CAPEOX-Serplulimab for MSS/pMMR Rectal Cancer With Oligometastases
Background and Significance: Colorectal cancer (CRC) ranks as the third most common cancer and the second leading cause of cancer-related deaths globally.
- Conditions
- Colorectal Carcinoma, Oligometastases, pMMR, MSS
- Trial name
- NCT06850103
- Testing
- short-course radiotherapy, CAPEOX/XELOX, Serplulimab
- Where
- China
- Volunteers
- 51 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hand Injuries, Finger Fracture
Percutaneous Pinning vs Orthosis and Early Mobilization
This study aims at investigating if splinting and early mobilization is a better method, regarding range of motion, for treating fractures of the base phalanx of the fingers compared to surgery with pinning.
- Trial name
- POEM (NCT04561661)
- Testing
- Percutaneous pinning, Conservative treatment
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Frailty, Pre-Frailty
Frailty Improvement Through Technology With Informal Caregiver Supported Exercise (FITWISE) for Pre-frail and Frail Community-dwelling Older Adults
The goal of this pilot trial is to evaluate the feasibility and potential effectiveness of a caregiver-mediated, technology-facilitated home-based intervention named Frailty Improvement through Technology With Informal Caregiver…
- Trial name
- FITWISE (NCT07519642)
- Testing
- FITWISE, Psychosocial support, Health education control
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Non Small Cell Lung Cancer, Respiratory Tract Neoplasm
Study for Evaluating the Safety and Feasibility of Fecal Microbiota Transplant in Stage II-III NSCLC Patients Using ICI Responders as Donors (MIGRANT)
This is a randomized, phase II, multi-centre clinical trial. Sample size: 68 patients (Experimental Arm (Durvalumab + chemotherapy + FMT capsules): 34 patients, Control Arm (Durvalumab + chemotherapy): 34 patients) Population…
- Trial name
- MIGRANT (NCT07247786)
- Testing
- Biological: Fecal Microbiota Transplantation, Durvalumab, Paclitaxel
- Where
- 20 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Fundación GECP
Bacterial Colonization, Multidrug Resistant Organisms
Enteral Nutrition and Colonization Resistance Through Microbiota Modulation in Critically Ill Patients
The goal of this clinical trial is to learn whether enteral nutrition enriched with fiber can influence gut microbiota and improve resistance to colonization with multidrug-resistant bacteria in critically ill patients.
- Conditions
- Bacterial Colonization, Multidrug Resistant Organisms, Critical Illness, Gut Microbiota Dysbiosis
- Trial name
- MICRON (NCT07719673)
- Testing
- Fibre-Enriched Enteral Nutrition, Standard Enteral Nutrition
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Tooth Discolouration
16% Carbamide Peroxide Home Bleaching: Soft vs. Rigid Tray in a Randomized Blinded Equivalence Trial
The aim of this clinical study is to evaluate patient satisfaction, bleaching efficacy, and the risk and severity of tooth sensitivity and gingival irritation during home bleaching with 16% carbamide peroxide using conventional…
- Trial name
- Rigid tray (NCT06881654)
- Testing
- Bleaching teeth
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Rey Juan Carlos
Myelofibrosis, Myelofibrosis (MF)
Comparing Momelotinib and Ruxolitinib in People With Untreated Myelofibrosis and Low Blood Cell Counts
The purpose of this study is to compare momelotinib and ruxolitinib as treatments for myelofibrosis with low blood cell counts. Both drugs are approved by the FDA to treat myelofibrosis.
- Trial name
- APEX-MF (NCT07498205)
- Testing
- Momelotinib, Ruxolitinib
- Volunteers
- 268 people
- Sponsor
- SWOG Cancer Research Network
Gout
Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered…
- Trial name
- TRUST (NCT04875702)
- Testing
- Allopurinol, Naproxen 250 MG, Colchicine 0.6 mg
- Where
- 7 sites in United States
- Volunteers
- 650 people
- Sponsor
- Massachusetts General Hospital
Arteriovenous Graft
LineMatrix® Biological Vascular Graft for the Creation of Arteriovenous Graft
The study is planned to be conducted at multiple centers, with an intended enrollment of 326 subjects. Protocol-eligible subjects will be randomized in a 1:1 ratio to either the investigational group or the control group.
- Trial name
- NCT07773051
- Testing
- LineMatrix® Biological Vascular Graft, GORE-INTERING®
- Where
- 12 sites in China
- Volunteers
- 326 people
- Sponsor
- Longhua Hospital
Ulcerative Colitis Acute
Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute Severe Ulcerative Colitis
The goal of this trial is to create personalized treatments for each patient admitted to the hospital with acute severe ulcerative colitis (ASUC).
- Trial name
- NCT05867329
- Testing
- Cyclosporine Injection (IV), Cyclosporine Oral Product, Upadacitinib Extended Release Oral Tablet
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Berinstein, Jeffrey
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