Clinical trials: Randomized, open to volunteers
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Virtual Reality, Children and Adolescents
Evaluation of the Efficacy of a Virtual Reality When Placing a Needle on an Implantable Venous Access Device in Children With Leukemia
Main objective: Evaluate the effectiveness of the repeated use of interactive or hypnotic virtual reality compared to standard treatment, on pain, during each needle placement on PAC for 3 months on children or adolescents (6 to…
- Conditions
- Virtual Reality, Children and Adolescents, Acute Leukemia, Anxiety and Fear
- Trial name
- LEAVE (NCT06697275)
- Testing
- Hypnotic Virtual reality, Interactive virtual reality, Standard method
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Malignant or Benign Pathology
Low Impact Laparoscopic in Colorectal Resection - PAROS2
To improve post-operative recovery, the concept of Low Impact Laparoscopy was developed in colo-rectal surgery with associating low-pressure pneumoperitoneum and microlaparoscopic surgery.
- Trial name
- PAROS2 (NCT04742881)
- Testing
- Low pressure + microsurgical instruments, Low pressure + standard instruments
- Where
- 3 sites in France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Bordeaux
Opioid Use Disorder
Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg).
- Trial name
- Optimal Bup (NCT06316830)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rhode Island Hospital
Accuracy of 3D Printed Titanium Plates Versus 3D Milled Titanium Plates in Genioplasty Orthognathic Surgery, Patient Specific Genioplasty
Accuracy of Patient Specific 3D Printed Titanium Plates Versus Milled Titanium Plates in Genioplasty Orthognathic Surgeries.
To assess accuracy of patient specific 3D printed titanium plates versus 3D milled titanium plates in genioplasty orthognathic surgery
- Conditions
- Accuracy of 3D Printed Titanium Plates Versus 3D Milled Titanium Plates in Genioplasty Orthognathic Surgery, Patient Specific Genioplasty, Accuracy of 3D Printed Titanium Plates Versus 3D Milled Titanium Plates in Genioplasty
- Trial name
- NCT07344441
- Testing
- genioplasty using 3D printed patient specific titanium plates (study group), genioplasty using 3D milled patient specific titanium plates (control group)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neoplasm, Cancer
Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial
The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients…
- Conditions
- Neoplasm, Cancer, Hemodynamic (MAP) Stability, Cancer Surgery
- Trial name
- FOCUS-AFM (NCT07314853)
- Testing
- Artificial Intelligence-Assisted Fluid Management, Standard fluid management
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- National Cancer Institute, Naples
Recurrent Chronic Lymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma
Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This phase II trial studies how well acalabrutinib and venetoclax with or without early obinutuzumab work for the treatment of chronic lymphocytic leukemia or small lymphocytic lymphoma that is high risk, has come back…
- Conditions
- Recurrent Chronic Lymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Small Lymphocytic Lymphoma
- Trial name
- NCT04169737
- Testing
- Acalabrutinib, Obinutuzumab, Venetoclax
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- M.D. Anderson Cancer Center
Sclerosis, Multiple, Neurocognitive Impairment, Mild
The DANCEREX Proof-of-Concept Study for Chronic Neurological Disorders
The goal of this clinical trial is to test a new digital therapeutic solution which combines a holistic, multidimensional rehabilitation program based on dance and music with an innovative motivational system (DANCEREX-DTx) in…
- Conditions
- Sclerosis, Multiple, Neurocognitive Impairment, Mild, Neurocognitive Dysfunction
- Trial name
- DANCEREX-DTx (NCT06112639)
- Testing
- DANCEREX-DTx, Multidimensional dance-based program, Educational Program
- Where
- 3 sites in Italy
- Volunteers
- 192 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Colitis, Ulcerative
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission.
- Trial name
- NCT05076175
- Testing
- Ozanimod
- Where
- 91 sites in United States, Australia and 11 more
- Volunteers
- 120 people
- Sponsor
- Bristol-Myers Squibb
Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol
Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices
Cirrhosis is a serious liver disease where scar tissue replaces healthy liver tissue, often leading to portal hypertension-a condition where blood pressure in the liver's blood vessels rises.
- Conditions
- Rebleeding of Portal Hypertension in Liver Cirrhosis, Propranolol, Carvedilol
- Trial name
- NCT07352228
- Testing
- Propranolol, Carvedilol
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Xijing Hospital
Obsessive-Compulsive Disorder
Safety and Efficacy of Pramipexole Treatment in Resistant Obsessive-Compulsive Disorder (OCD)
The most common and effective treatment for OCD is pharmacological therapy that includes selective serotonin reuptake inhibitors (SSRIs) antidepressants and, in the case of patients resistant to this approach, a combination with…
- Trial name
- OCD-RT (NCT06611592)
- Testing
- Pramipexole 0.088mg/tid, Pramipexole 0.18 mg/tid, Pramipexole 0.35 mg/tid
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Acute Ischemic Stroke
Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2.
- Trial name
- NOTICE-1 (NCT07049692)
- Testing
- Hyperbaric Oxygen Therapy, Conventional therapy group
- Where
- 2 sites in China
- Volunteers
- 424 people
- Sponsor
- Beijing Chao Yang Hospital
Stroke
Effects of Plantar Vibration on Gait and Balance in Stroke
This study aims to evaluate the effects of local vibration applied to the plantar surface of the foot on gait speed and dynamic balance in individuals with stroke.
- Trial name
- NCT07551141
- Testing
- Plantar Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Bitlis Eren University
Cataract
A Prospective, Randomized, Subject- and Examiner-Masked, Multicenter Study Comparing Bilateral Clareon TruPlus and Bilateral Clareon Monofocal Intraocular Lens Implantation (Spherical and Toric) in Cataract Subjects
This investigator-initiated trial is a prospective, randomized, parallel-group, bilateral implantation study comparing Clareon TruPlus versus Clareon monofocal intraocular lenses (IOLs).
- Trial name
- NCT07693205
- Testing
- Clareon TruPlus, Clareon monofocal
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Berkeley Eye Center
Hypertension, Pre Hypertension
Breathing Exercises of CardioBreath Application on Autonomic and Vascular Function in Hypertension
Hypertension is one of the greatest public health challenges, affecting more than one billion people worldwide and representing a significant financial and public health burden.
- Trial name
- CardioBreath (NCT06917729)
- Testing
- CardioBreath
- Where
- 2 sites in Brazil
- Volunteers
- 66 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Bacteria Infection, Piperacillin, Tazobactam Drug Combination
Subcutaneous Piperacillin/Tazobactam Compared With Intravenous Treatment
The goal of this clinical trial is to learn whether subcutaneous piperacillin/tazobactam can provide drug exposure similar to standard intravenous piperacillin/tazobactam in adults who need treatment for an infection.
- Trial name
- STUPITA01 (NCT07481539)
- Testing
- Piperacillin, Tazobactam Drug Combination
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Sanitaria Universitaria Friuli Centrale
Anxiety State
Evaluation of an Anxiety Reduction Tool During Thyroid Biopsies
Patients undergoing thyroid biopsy under local anesthetic will be asked to fill out a questionnaire that evaluates their anxiety level before and after their procedure.
- Trial name
- NCT06358612
- Testing
- Stress Balls
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Nova Scotia Health Authority
Dental Caries, Dental Cavities
Evaluation of Selective and Stepwise Excavation in Young Permanent Teeth With Deep Caries Lesions.
The purpose of this clinical trial is to evaluate and compare the outcomes of selective carious tissue removal versus stepwise carious tissue removal in young permanent teeth with deep carious lesions.
- Trial name
- SELECT (NCT06944028)
- Testing
- Selective excavation, Stepwise excavation
- Where
- Sweden
- Volunteers
- 666 people
- Sponsor
- Karolinska Institutet
Blood Pressure Monitoring, Neuroendovascular Procedures
Pressure Sensing Sheath Blood Pressure Monitoring Compared to Traditional Methods in Interventional Procedures
This observational study aims to evaluate the accuracy and safety of pressure sensing sheath blood pressure monitoring compared to traditional invasive and non-invasive blood pressure monitoring methods during neuroendovascular…
- Trial name
- NCT07257367
- Testing
- Pressure Sensing Sheath Monitoring, Radial Arterial Line Monitoring
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Fourth People's Hospital Tongji University
Caregiver Participation, Emergency Department Presentation
Supporting Caregivers Following Mental Health Emergency Department Visits
The investigators plan to conduct a pilot hybrid effectiveness-implementation type 1 randomized controlled trial comparing 3 arms of varying follow-up intervention.
- Conditions
- Caregiver Participation, Emergency Department Presentation, Safety Plan
- Trial name
- SCFMHEDV (NCT07411300)
- Testing
- Telephone Calls, Automatic MyChart Messages
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
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