Clinical trials: Randomized Controlled Trial, Human Study
Neisseria Gonorrhea
Safety and Immunogenicity Study of a Multivalent Gonorrhoea Vaccine
The main goal of this trial is to evaluate the safety and immunogenicity of the candidate N. gonorrhoeae vaccine, LTB-NG6.
- Trial name
- LTBNG601 (NCT07758972)
- Testing
- LTB-NG6, Sodium Chloride 0.9%
- Where
- Germany
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Emerging Infectious Diseases, COVID-19
Smart Analysis and Decision-Making for Emerging Infectious Diseases
Emerging infectious diseases, such as COVID-19, mpox, and dengue fever, are characterized by rapid transmission, wide impact, and high uncertainty, posing ongoing threats to global public health.
- Conditions
- Emerging Infectious Diseases, COVID-19, Influenza, Mpox (Monkeypox)
- Trial name
- SMART-ID (NCT07678619)
- Testing
- Multi-Agent Integrated Smart Toolkit for Emerging Infectious Diseases, Routine Practices
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Peking University
Influenza
Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza
This study is a global multicenter randomized factorial double-blind, placebo-controlled trial designed to evaluate (i) efficacy and safety of nitazoxanide 600 mg administered orally twice daily for five days compared to a…
- Trial name
- NCT01610245
- Testing
- Nitazoxanide, Oseltamivir
- Where
- 167 sites in United States, Australia and 3 more
- Volunteers
- 1,941 people
- Sponsor
- Romark Laboratories L.C.
Human Papilloma Virus
A Cohort Study of Hyperthermia and Imiquimod for the Treatment of Flat Warts
flat warts are a superficial viral skin disease, extremely common in childhood.Treatment of warts is often difficult and involves different destructive procedures.Although several pharmacological and physical topical treatments…
- Trial name
- NCT05146895
- Testing
- Imiquimod treatment, Local Hyperthermia at 44℃
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Healthy
A Study of JNJ-64281802 Against Dengue Serotype 1 Infection in a Dengue Human Challenge Model in Healthy Adult Participants
The purpose of this study is to assess the antiviral activity of JNJ-64281802 versus placebo in terms of reduction of dengue virus 1 (DENV-1) ribonucleic acid (RNA) viral load (VL).
- Trial name
- NCT04480736
- Testing
- JNJ-64281802 High dose, JNJ-64281802 Medium dose, JNJ-64281802 Low dose
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Post-Amputation Phantom Limb Pain
Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study
When a limb is severed, pain perceived in the part of the body that no longer exists often develops and is called "phantom limb" pain.
- Trial name
- NCT03449667
- Testing
- Cryoneurolysis
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Diego
Immunity
the Efficacy and Safety of Curcuma Longa Extract Mixture on Immune Enhancement
This study was conducted to investigate the efficacy and safety of Curcuma longa extract mixture on immune enhancement
- Trial name
- NCT05324800
- Testing
- Curcuma Longa Extract Mixture
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Viremia
Yellow Fever Virus Vaccine and Immune Globulin Study
The purpose of this study is to determine whether immune globulin can limit the amount of yellow fever vaccine virus present in the blood after vaccination without compromising the immunity associated with the yellow fever…
- Trial name
- NCT00254826
- Testing
- YF-VAX® plus saline, 17D YF Vaccine plus Ig,
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Hepatitis E
Study of AT-587 in Healthy Subjects
This study will assess the safety, tolerability and pharmacokinetics (PK) of AT-587 in healthy subjects
- Trial name
- NCT07728487
- Testing
- AT-587
- Where
- Belgium
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Coronary Artery Disease
The "CAD-Man" EXTEND Study
CAD-Man Extend is the long-term follow-up (clinical, laboratory, and computed tomography (CT) imaging) of a single-center, randomized, controlled CAD-Man trial comparing a CT-first strategy with a direct- invasive coronary…
- Trial name
- CAD-Man-EXTEND (NCT06237673)
- Testing
- CT, invasive coronary angiography (ICA)
- Where
- Germany
- Volunteers
- 318 people
- Sponsor
- Charite University, Berlin, Germany
HCV
TMC435350-TiDP16-C109: A Safety Study for TMC435350 in an Oral Solution Containing Either 100, 200 or 400 mg Equivalent of TMC435350 or Placebo in Healthy Japanese Male Volunteers
The purpose of this study is to evaluate the safety and tolerability of three different doses of TMC435350 compared to placebo in healthy Japanese males.
- Trial name
- NCT00752544
- Testing
- TMC435350
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Immunization Programs
Increasing the Uptake of Influenza and Pneumococcal Vaccines Among High-Risk Adult Patients Through GP Clinics
Pneumonia and influenza are among the top causes of hospitalisation and death in the elderly. While vaccinations are recommended against these diseases, a large proportion of elderly in the community remain unvaccinated, with…
- Trial name
- NCT03445117
- Testing
- Educational intervention
- Where
- 2 sites in Singapore
- Volunteers
- 8,837 people
- Sponsor
- Tan Tock Seng Hospital
Infection, Human Immunodeficiency Virus
Dose-finding Study of BMS-955176 to Treat HIV-1 Infected Treatment-naive Adults
The purpose of this study is to find at least one dose of BMS-955176 that will be safe, effective and tolerable for HIV-1 infected treatment naive adults.
- Trial name
- NCT02415595
- Testing
- BMS-955176, EFV, TDF/FTC
- Where
- 64 sites in United States, Argentina and 10 more
- Volunteers
- 210 people
- Sponsor
- ViiV Healthcare
Chronic Hepatitis B
Prednisolone Priming Study in Patients With Chronic Hepatitis B
Study purpose: To investigate whether ALT rebound following corticosteroid priming enhances response to telbivudine therapy. Efficacy assessments: The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without…
- Trial name
- NCT00778596
- Testing
- Prednisolone
- Where
- 4 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- Yun-Fan Liaw
HIV Infections
TMC114-C201: A Study to Determine the Antiviral Activity of TMC114 in Patients With Multiple Protease Inhibitor (PI) Resistant Human Immunodeficiency Virus (HIV) Strains
The purpose of this study is to determine the antiviral activity, safety and tolerability of 14 days of different doses of TMC114 to treat HIV-1 positive patients whose condition is failing on a current treatment regimen that…
- Trial name
- NCT00964327
- Testing
- TMC114
- Volunteers
- 42 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Parkinson Disease
A Study to Evaluate the Human Tolerance and Pharmacokinetics of LY03003
This study is to evaluate the human tolerance and pharmacokinetics of LY03003.
- Trial name
- NCT04627155
- Testing
- LY03003
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Healthy Volunteers
A Research Study Looking at the Safety of Single and Multiple Doses of ZP9830 and How it Works in the Body of Healthy Participants
The primary object in this research study is to investigate the safety and tolerability of ZP9830 in healthy study participants, and in addition, the study will investigate how ZP9830 works in the body (pharmacokinetics, PK and…
- Trial name
- NCT06682975
- Testing
- ZP9830
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Zealand Pharma
Healthy
A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers
This is a first in man, prospective, single-center, randomized, double-blind, dose-escalation cohort study to investigate tolerability, safety and pharmacokinetics of rVIIa-FP in comparison to placebo.
- Trial name
- NCT01542619
- Testing
- rVIIa-FP
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CSL Behring
Influenza
High Dose Influenza Vaccine in Nursing Home - Pilot Study
The purpose of this pilot evaluation is to help determine the feasibility and power needed to prospectively evaluate relative effectiveness of high-dose influenza vaccine in preventing influenza mortality and hospitalization in a…
- Trial name
- NCT01720277
- Testing
- HD Fluzone Vaccine, SD Fluzone Vaccine
- Where
- 2 sites in United States
- Volunteers
- 2,957 people
- Sponsor
- Insight Therapeutics, LLC