Clinical trials: Randomized-controlled Trial
Immediate Provisional Prosthesis
This Study Aims to Evaluate the Soft Tissue Response and Prosthetic Complications Associated With Three Different Types of Provisional Prosthesis Used in Immediate Loading Full-arch Implant Prosthetic Treatment. The Patients Are Randomly Assigned to the Three Groups to Compare the Clinical Outcomes
This study aims to evaluate the soft tissue response and prosthetic complications associated with three different types of provisional prostheses used in immediate loading full-arch implant prosthetic treatment.
- Trial name
- NCT07395167
- Testing
- 3D printed provisional full arch prosthesis, Bar reinforced 3D printed provisional full arch prosthesis, Milled PMMA provisional full arch prosthesis
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Mansoura University
Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections
PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN)
Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae blood-stream infection are lacking.
- Conditions
- Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections, Bacteremia
- Trial name
- PETERPEN (NCT03671967)
- Testing
- Piperacillin/tazobactam, Meropenem
- Where
- 14 sites in Canada, Israel
- Volunteers
- 1,084 people
- Sponsor
- Rambam Health Care Campus
Cognitive Decline, Mild, Alzheimer Disease
Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD)
The goal of this placebo-controlled double-blind Phase 2 clinical trial is to test in people with early Alzheimer's Disease. The main questions it aims to answer are: Does treatment with fasudil, a ROCK-inhibitor, lead to…
- Trial name
- FEAD (NCT06362707)
- Testing
- Fasudil
- Where
- 6 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Helse Stavanger HF
Infertility
Ultrasound Guidance for Embryo Transfer
Randomized controlled study comparing the TVUS versus TAUS guidance during the procedure of embryo transfer.
- Trial name
- NCT03851536
- Testing
- Transvaginal Ultrasound Guided ET, Transabdominal Ultrasound Guided ET
- Where
- 2 sites in Egypt
- Volunteers
- 178 people
- Sponsor
- Menoufia University
Infantile Colic, Reflexology
The Effect of Foot Reflexology on Infantile Colic Symptoms
Aim: To compare the effect of foot reflexology and placebo foot reflexology on colic symptoms such as pain, ineffective sleep, and colicky crying periods in infants with colic.
- Trial name
- NCT03939611
- Testing
- Foot Reflexology
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cervical Cancer Screening, Breast Cancer Screening
Social Media-Based Education on Cancer Screening Awareness in Women: A Randomized Controlled Trial
This randomized controlled study evaluated a social media-based educational program for women who had not previously participated in breast, cervical, or colorectal cancer screening.
- Conditions
- Cervical Cancer Screening, Breast Cancer Screening, Colorectal Cancer Screening, Digital Health Literacy
- Trial name
- NCT06939699
- Testing
- Social Media-Based Education, Standard Online Education
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Emine Ergin
Hypogonadism
A Study to Test a Measure of Symptoms of Older Men With Low Testosterone On and Off Testosterone Replacement Treatment (P05815)
Hypogonadal males, particularly those whose condition manifested later in life, may experience common symptoms associated with their hypogonadism. Questionnaires developed to assess these symptoms need to be tested.
- Trial name
- NCT00254553
- Testing
- Testim 1% (testosterone gel)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Covid19
Clinical Efficiency of Surgical Masks and Filtering Face-piece 2 Masks
Recent results demonstrated an increased risk of COVID-19 infection among healthcare workers (HCW), particularly when access to personal protective equipment (PPE) was inadequate. (ref).
- Trial name
- NCT04823351
- Testing
- Surgical Mask
- Where
- Switzerland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Overweight , Obesity, Prediabetes
Smartwatch-based Intervention for Cardiovascular Health (SWITCH)
This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among metabolically at-risk people with overweight/obesity…
- Conditions
- Overweight , Obesity, Prediabetes, High-normal Blood Pressure, Borderline Elevated Blood Lipids
- Trial name
- NCT07372729
- Testing
- Smartwatch-Based Multi-Faceted Behavioral Intervention Model Led by Exercise and Dietary Interventions, Supported by Primary Medical Staff, Along with the Distribution of Health Education Manuals, Face-to-face health education sessions
- Where
- 3 sites in China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Knee Replacement Surgery, Osteoarthritis, Knee
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery.
- Trial name
- CORK (NCT06234631)
- Testing
- Epidiolex oral solution
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- Chad Brummett
Eustachian Tube Dysfunction
Balloon Dilation of the Eustachian Tube
In this study, patients with dysfunction of the eustachian tube will be included. They will be randomized to one of two treatment groups. 1. balloon dilation of the eustachian tube or 2.
- Trial name
- BDET (NCT05270031)
- Testing
- Balloon dilation of the eustachian tube
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute on Chronic Liver Failure, Hepatitis B
Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure
Background: Reactivation of hepatitis B is a well-characterized syndrome marked by the abrupt reappearance or rise of hepatitis B virus (HBV) DNA in the serum of a patient with previously inactive or resolved HBV infection.
- Trial name
- ACLF (NCT01074645)
- Testing
- Tenofovir disoproxil fumarate (TDF)
- Where
- India
- Volunteers
- 27 people
- Sponsor
- Govind Ballabh Pant Hospital
Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus
Treatment of Diabetic Neuropathy With Liraglutide
The purpose of this trial is to explore whether liraglutide has a long term effect on clinical symptoms and biomarkers in patients with diabetic neuropathy.
- Trial name
- TODINELI (NCT02138045)
- Testing
- Liraglutide treatment
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Aalborg University Hospital
Prevention Harmful Effects
Comparison of 2 Body Oil in Prevention of Striae Gravidarum
The effect of elasticity Belly® oil and Clarins® Tonic Body Treatment Oil in prevention of striae gravidarum: A randomized controlled clinical trial.
- Trial name
- NCT02879045
- Testing
- Elasticity Belly® oil
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shanghai Changning Maternity & Infant Health Hospital
Bacteraemia Caused by Gram-Negative Bacteria
Antibiotic Durations for Gram-negative Bacteremia
Gram-negative bacteremia (GNB) is a frequent hospital \& community-acquired infection, yet there is as yet no evidence from randomized studies on the optimal duration of antibiotic therapy.
- Trial name
- PIRATE (NCT03101072)
- Testing
- "Fixed long" antibiotic course of 14 days, "Fixed short" antibiotic course of 7 days, "Individualized duration" of antibiotic therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 504 people
- Sponsor
- University of Geneva, Switzerland
Chronic Subdural Hematoma, Recurrence
The Effectiveness and Safety of Body Posture in Preventing Postoperative Recurrence for Chronic Subdural Hematoma
This study aims to investigate the effectiveness and safety of body posture to improve intracranial pressure in preventing postoperative recurrence for chronic subdural hematoma
- Trial name
- NCT06401772
- Testing
- Intracranial Hypotension Targeted(IHT) Body Posture
- Where
- China
- Volunteers
- 830 people
- Sponsor
- Huashan Hospital
SARS-CoV-2
Clinical Trial of COVID-19 Vaccine（SARS-CoV-2 Variant(Omicron BA.5) mRNA Vaccine） in Participants Aged 18 Years and Over
This is a single-center, randomized, blinded, placebo-controlled clinical trial to evaluate the protective efficacy, safety and immunogenicity of one dose of the SARS-CoV-2 variant (Omicron BA.5) mRNA vaccine in people aged 18…
- Trial name
- NCT05745545
- Testing
- SARS-CoV-2 Variant (Omicron BA.5) mRNA vaccine, Saline solution
- Where
- China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- AIM Vaccine Co., Ltd.
Diabetes
Avoiding Diabetes After Pregnancy Trial in Moms
Mothers with previous gestational diabetes mellitus (GDM) represent a population at higher risk of future Type 2 diabetes mellitus (T2DM), which is preventable through lifestyle modification.
- Trial name
- ADAPT-M (NCT01918345)
- Testing
- Home-based Physical Activity Program with Health Coach, Home-based Low-GI Diet Program with Health Coach
- Where
- 5 sites in Canada
- Volunteers
- 345 people
- Sponsor
- Women's College Hospital
Xerostomia, Diabetes Mellitus
Photobiomodulation In Treatment Of Xerostomia In Type Ii Diabetic Patients
Xerostomia is a major oral health problem that if not recognized and treated can have a significant effect on a patient's quality of life. It leads to difficulties with speech, swallowing and taste alteration.
- Trial name
- NCT06703372
- Testing
- Diode Laser 980 nm, 0.2W
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Hams Hamed Abdelrahman
Pancreas Cancer, Quality of Life
Adapted Physical Activity in Patients With Resected Pancreatic Cancer (APACaPOp PRODIGE-56 Study): a National Multicenter Randomized Controlled Phase II Trial
Exercise during chemotherapy (CT) is a promising strategy to reduce fatigue and improve health-related quality of life (HRQoL). Exercise may also have beneficial effects on tumor outcome by decreasing insulin resistance…
- Trial name
- APACaPOp (NCT03400072)
- Testing
- Unsupervised APA program, Supervised APA program
- Where
- 15 sites in France
- Volunteers
- 252 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
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