Clinical trials: Randomized-controlled Trial
Colorectal Disorders
Enhanced Recovery Program After Laparoscopic Colorectal Surgery During The Era Of COVID-19
The investigators included all patients who were subjected to laparoscopic colorectal surgery at investigators' center between ( December 2019 to December 2021) for benign \& malignant conditions.
- Trial name
- NCT05240053
- Testing
- enhanced recovery programe
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Zagazig University
Cardiomegaly, Noonan Syndrome
MEK Inhibitors for the Treatment of Hypertrophic Cardiomyopathy in Patients With RASopathies
The goal of this study is to evaluate the effectiveness of trametinib treatment in patients with Hyperthropic cardiomyopathy and a genetic mutation in the RAS/MAPK pathway.
- Trial name
- MEKinRAS (NCT06555237)
- Testing
- Trametinib tablet, Standard therapy
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Warsaw
Burns
Education Program for Burn Patients
The purpose of this study is to assess the effect of an educative program including telephone follow-up for burn patients regarding the impact of this intervention on the health status and return to work at six months after…
- Trial name
- NCT01379495
- Testing
- educational program+telephone follow up
- Where
- Brazil
- Volunteers
- 83 people
- Sponsor
- University of Sao Paulo
Helicobacter Pylori
7-Day Vonoprazan, High-Dose Amoxicillin, and Bismuth Therapy
The 2024 American College of Gastroenterology (ACG) Clinical Guideline recommends a 14-day vonoprazan-amoxicillin (VA) regimen, consisting of vonoprazan 20 mg twice daily with amoxicillin 1000 mg three times daily, as a…
- Trial name
- JSHERO4 (NCT07232095)
- Testing
- VAB-7, VA-14
- Where
- China
- Volunteers
- 316 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Covid19, Covid-19 ARDS
Efficacy and Safety of Remdesivir and Tociluzumab for the Management of Severe COVID-19: A Randomized Controlled Trial
This randomized clinical trial was designed and intended to evaluate the efficacy of Remdesivir and Tocilizumab as a treatment for severe Acute Respiratory Distress Syndrome (ARDS) caused by Coronavirus disease 2019 (COVID-19).
- Trial name
- NCT04678739
- Testing
- Remdesivir, Tocilizumab
- Where
- 4 sites in Bangladesh
- Volunteers
- 205 people
- Sponsor
- M Abdur Rahim Medical College and Hospital
Colon Mucous, Colonoscopy
Dose the Saline Reduce the Mucus Production When Water Exchange Colonoscopy is Used?
This is a study to compare the left colon mucus production between carbon dioxide (CO2) insufflation and water exchange (WE) colonoscopy in patients that require a routine or repeat colonoscopy.
- Trial name
- NCT04769739
- Testing
- CO2, Water, 50% saline
- Where
- Taiwan
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
HIV Infection, HCV Coinfection
Folinic Acid: Supplementation and Therapy
Patients infected by HIV or HIV-HCV coinfected have higher survival due to the use of HAART, but survival is accompanied by increased morbidity and associated cardiovascular disease (CVD).
- Trial name
- FAST (NCT02810275)
- Testing
- Folinic Acid
- Volunteers
- 69 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Postsurgical Pain
Effect of Oliceridine Patient-Controlled Intravenous Analgesia on Postoperative Chronic Pain After Video-Assisted Thoracoscopic Lung Resection
The primary objective is to evaluate the impact of oliceridine versus sufentanil for perioperative analgesia on the incidence of chronic postsurgical pain (CPSP) with functional impact in patients undergoing video-assisted…
- Trial name
- NCT07018375
- Testing
- Oliceridine, Sufentanil
- Where
- 7 sites in China
- Volunteers
- 320 people
- Sponsor
- Tianjin Medical University General Hospital
Immunogenicity, Efficacy
New Generation mRNA Booster Vaccine Against Emerging VOCs
Primary：Objectives ：SafetyTo describe the safetyprofile of all participants in each group up to 6months post-dose.Immunogenicity：To demonstrate the superiorityof neutralizing antibodyresponse in terms of geometric mean titers…
- Conditions
- Immunogenicity, Efficacy, Safety
- Trial name
- NCT05580159
- Testing
- SW-BIC-213, SARS-Cov-2 Vaccina(Vero Cell ) Inactivated
- Where
- Laos
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Stemirna Therapeutics
Haemodynamic Stability
Evaluation of the Role of Low Dose Magnesium Sulfate in Anesthesia for Toxic Goiter Resection
Anesthesia for toxic goiter removal is a challenging because of of hemodynamic instability especially during induction, intubation, manipulations of the gland, after removal of the gland and during emergence.
- Trial name
- Anesthesia (NCT04632524)
- Testing
- MgSO4
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Myopia Progressing
Clinical Efficacy and Mechanism Exploration of MR-61 in Delaying the Progression of Myopia
To investigate whether probiotic MR-61 can assist in slowing down the progression rate of myopia (a prospective randomized controlled study).
- Trial name
- NCT07298824
- Testing
- Investigational Bifidobacterium Preparation MR-61
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Preeclampsia
Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial
This is a prospective, multicenter, randomized controlled, double-blind trial of three treatment arms: (1) aspirin 75 mg/day vs. (2) aspirin 150 mg/day vs.
- Trial name
- NCT05580523
- Testing
- 75 mg acetylsalicylic acid, 1.5g Metformin, 150 mg acetylsalicylic acid
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Non Proliferative Diabetic Retinopathy
Study to Evaluate Efficacy and Safety of Entelon 50mg in Patients With Non-Proliferative Diabetic Retinopathy
This clinical trial is a multi-center, double-blind, randomized, placebo controlled , parallel design, superiority, phase 4 study to evaluate the efficacy and safety of Entelon 50mg in 396 patients with non-proliferative diabetic…
- Trial name
- NCT05358080
- Testing
- Entelon Tab. 50mg
- Where
- South Korea
- Volunteers
- 396 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Poly Cystic Ovary Syndrome
Efficacy of Alpha Lipoic Acid Combined With Myo-Inositol in Non-Diabetic PCOS Patients
This study evaluates the efficacy of alpha-lipoic acid combined with myo-inositol, with or without metformin, in improving menstrual regularity and ovulation in non-diabetic women with polycystic ovary syndrome (PCOS).
- Trial name
- ALA-MYO-PCOS (NCT07630779)
- Testing
- Myo-inositol, Folic Acid, Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Beni-Suef University
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
Endometriosis
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
This randomized, controlled study will investigate the efficacy of a dietary intervention for women with endometriosis. Participants will be randomly assigned to follow a whole food plant-based (intervention) diet or stay on…
- Trial name
- NCT07090096
- Testing
- A whole food plant based diet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Gingival Overgrowth
Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth
Phenytoin, a common anti-seizure drug, leads to cosmetically unacceptable side effect of gingival overgrowth in a significant number of patients.
- Trial name
- PIGO (NCT00781196)
- Testing
- folic acid
- Where
- India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Pain, Postoperative
Injection of Local Anesthetic to Trocar Insertion Sites After Laparoscopy
The primary objective of this study is to assess if injection of local anesthetic to the laparoscopic trocar sites after a hysterectomy will make a difference in a patient's pain after surgery.
- Trial name
- NCT01688596
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Milton S. Hershey Medical Center
Exercise Performance
Medium-Term Supplementation With Herbal Extract for Exercise Performance and Antioxidant Status
We evaluated here the effects of 6-week intervention with herbal supplement on exercise performance outcomes and serum biomarkers of antioxidant status.
- Trial name
- PhytoDyNAmic (NCT04263246)
- Testing
- PhytoDyNAmic, Inulin
- Where
- Serbia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Hyperuricemia
Traditional Chinese Medicine in the Treatment of Patients With Hyperuricemia.
To testify the efficacy and safety of traditional Chinese formulae, "Wu-Ling San" and "Yin-Chen Wu-Ling San" for patients with hyperuricemia.
- Trial name
- NCT04144088
- Testing
- Wu Ling San, Yin-Chen Wu Ling San
- Volunteers
- 60 people
- Sponsor
- Chung Shan Medical University
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