Clinical trials: Randomized-controlled Trial
Post-traumatic Stress Disorder
Trial of Hydrocortisone for Post-Traumatic Stress Disorder (PTSD)
Developing novel and effective pharmacologic interventions for this post-traumatic stress disorder is important. The investigators propose to replicate findings of an earlier published pilot study using low dose hydrocortisone as…
- Trial name
- NCT00706173
- Testing
- Hydrocortisone
- Where
- United States
- Sponsor
- University of California, San Diego
Lymphedema of Face, Neoplasms
Manual Lymph Drainage for External Lymphedema
This study will evaluate the feasibility of a randomized controlled trial. The future randomized controlled trial will compare two groups following different intensities of manual lymphatic drainage for external head- and neck…
- Conditions
- Lymphedema of Face, Neoplasms, Radiotherapy Side Effect, Lymphedema Due to Radiation
- Trial name
- MLD-HN (NCT07215169)
- Testing
- HIT, LIT
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Lund University
Chronic Nonspecific Low Back Pain
Effects of SIS Therapy in Individuals With Chronic Nonspecific Low Back Pain
Brief Summary - buraya yapıştırın Chronic nonspecific low back pain is a common condition that can cause pain, limitations in daily activities, and reduced quality of life.
- Trial name
- NCT07839169
- Testing
- SIS Therapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Chronic Pain
A Community-Based Chronic Pain Self-Management Program in West Virginia
Chronic pain (CP) affects 1 in 3 US adults and costs up to $635 billion annually in medical costs and lost work productivity. Use of opioid medications for CP has risen in the US, and opioid overdose deaths have quadrupled, yet…
- Trial name
- NCT03582683
- Testing
- Chronic Pain Self-Management Program (CPSMP)
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- West Virginia University
Type 2 Diabetes Mellitus
Efficacy and Safety of Pueraria Lobata Radix As an Adjuvant Treatment for Type 2 Diabetes Mellitus
As a dietary herb, pueraria lobata radix (PLR) has been showed to have hypoglycemic effects in animal experiments. However, there is currently a lack of evidence from randomized controlled trials.
- Trial name
- NCT06494683
- Testing
- Pueraria lobata radix
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Healthy
Effects of Respiratory Muscle Training on Tongue Muscle Function
This study aims to investigate the effects of respiratory muscle training on tongue muscle function in healthy subjects. We hypothesize that respiratory muscle training can improve strength and endurance of the tongue muscles.
- Trial name
- NCT06627283
- Testing
- IMT, EMT
- Where
- 3 sites in Belgium, Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Researchers Attention
Readers' Attention of Shorter Versus Longer Abstracts of Systematic Reviews
The present randomized controlled trial (RCT) was designed to investigate the perceptions of researchers on systematic review (SR) abstracts.
- Trial name
- NCT06525805
- Testing
- Long Abstract, Short Abstract
- Where
- Germany
- Volunteers
- 1,941 people, healthy volunteers welcome
- Sponsor
- University of Oldenburg
Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
QL1706 in Combination With Neoadjuvant Chemotherapy Versus Neoadjuvant Chemotherapy for Locally Advanced, Resectable Esophageal Squamous Cell Carcinoma
This is a randomized, double-blind, placebo-controlled Phase II/III clinical trial to evaluate the perioperative treatment with QL1706 in combination with neoadjuvant chemotherapy for locally advanced resectable esophageal…
- Trial name
- NCT06852456
- Testing
- Iparomlimab and Tuvonralimab (QL1706)Injection, Paclitaxel, Cisplatin
- Volunteers
- 30 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Pregnancy Related, Anemia, Iron Deficiency
Early Antenatal Support for Iron Deficiency Anemia
This is a randomized, controlled multi-site trial of iron therapy in pregnancy. The purpose of this research is to see if second trimester initiation of intravenous (IV) iron therapy is better than oral iron therapy for treatment…
- Conditions
- Pregnancy Related, Anemia, Iron Deficiency, Anemia of Pregnancy
- Trial name
- EASI-A (NCT04278651)
- Testing
- Ferumoxytol, Ferrous Sulfate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Thomas Jefferson University
Compensated Liver Cirrhosis, Metabolic Dysfunction Associated Steatohepatitis (MASH)
A Study to Test How Well BI 770371 is Tolerated by People With Cirrhosis Caused by a Liver Disease Called MASH
This study is open to people with cirrhosis caused by a liver disease called MASH (metabolic dysfunction-associated steatohepatitis). The purpose of this study is to find out how well a medicine called BI 770371 is tolerated.
- Trial name
- NCT06675929
- Testing
- BI 770371
- Where
- 13 sites in United States
- Volunteers
- 28 people
- Sponsor
- Boehringer Ingelheim
Smoking Cessation
Promoting Smoking Cessation in the Community Via Quit to Win Contest 2013
According to the Census \& Statistics Department (2011), there are still 659,300 daily smokers (11.1%) in Hong Kong. Smoking and passive smoking kill over 7,000 people per year.
- Trial name
- NCT01928251
- Testing
- Informed early monetary incentive, Uninformed early monetary incentive
- Where
- China
- Volunteers
- 1,143 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Coronary Artery Disease
Colchicine Protective Effect in Patients Undergoing Percutaneous Coronary Intervention (COLCHICINE-PROTECT)
The goal of this clinical trial is to evaluate the colchicine protective effect in patients undergoing Percutaneous Coronary Intervention (PCI).
- Trial name
- NCT05739929
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Helwan University
Major Depressive Disorder, Generalized Anxiety Disorder
Augmenting Mental Health Support Through a Supportive Text Messaging Program
Patients seeking mental health care and those being discharged from psychiatric units frequently express psychological distress.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Mental Health Wellness 1
- Trial name
- Text4Support (NCT05411302)
- Testing
- Mental health supportive text messages
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- Vincent Agyapong
Impaired Wound Healing, Venous Insufficiency of Leg
Clinical Trial to Evaluate Blister Graft Utilizing a Novel Harvesting Device for Treatment of Venous Leg Ulcers
Epidermal grafts are believed to promote healing by two mechanisms: graft take and the promotion of wound healing through the delivery of growth factors and the essential elements of tissue repair and wound healing.28 This study…
- Conditions
- Impaired Wound Healing, Venous Insufficiency of Leg, Diabetic Ulcers
- Trial name
- Cellutome (NCT02148302)
- Testing
- Harvesting Device (CelluTome©)
- Where
- 18 sites in United States
- Volunteers
- 123 people
- Sponsor
- SerenaGroup, Inc.
Adenoma Colon
The Effect of Clip-traction on ESD Resection Time.
Patients scheduled for an endoscopic submucosal dissection(ESD) in the colorectum will be randomized to the use of a traction device(consisting of an endoscopic clip with a loop of dental floss secured in the lesion to be…
- Trial name
- NCT04756453
- Testing
- clip-traction
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 2
Study to Evaluate Safety and Efficacy of Dapagliflozin and Saxagliptin in Patients With Type 2 Diabetes Mellitus (T2DM) Aged 10 to Below 18 Years Old
The primary objective of this study is to determine if there will be a greater mean reduction from baseline in glycated hemoglobin (HbA1c) achieved after 26 weeks of oral double-blind add-on therapy of dapagliflozin or…
- Trial name
- NCT03199053
- Testing
- Dapagliflozin, Saxagliptin
- Where
- 122 sites in United States, Argentina and 21 more
- Volunteers
- 256 people
- Sponsor
- AstraZeneca
COVID-19
Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals
This is a phase III clinical trial to assess efficacy and safety of the Adsorbed COVID-19 (inactivated) vaccine manufactured by Sinovac in health care professionals
- Trial name
- PROFISCOV (NCT04456595)
- Testing
- Adsorbed COVID-19 (inactivated) Vaccine
- Where
- 16 sites in Brazil
- Volunteers
- 12,688 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Hypertension, Anxiety
Comparison of Tandospirone, Amlodipine and Their Combination in Adults With Hypertension and Anxiety
This study compares the antihypertensive effects between different treatment groups including antihypertensive drug, anxiolytic, and both, which provide a new clinical evidence for controlling blood pressure in patients with…
- Trial name
- NCT03667677
- Testing
- Tandospirone + Amlodipine
- Where
- 7 sites in China
- Volunteers
- 256 people
- Sponsor
- Chongqing Medical University
Periodontal Health
Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on the Periodontal Health
The study aims to evaluate the effect of using PRF and vitamin Dꝫ injections on periodontal health and parameters and compare them when used to facilitate orthodontic treatment.
- Trial name
- NCT06223477
- Testing
- Platelet-rich Fibrin, Vitamin D3
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Beni-Suef University
Delirium
Ramelteon Prevention of Delirium - RCT
Delirium is a common morbid condition in hospitalized adults. Treatment of delirium has been unsatisfactory and prevention is the preferred goal.
- Trial name
- NCT02564939
- Testing
- ramelteon
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Hartford Hospital
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